Comparative Analysis of Iodine Levels, Biochemical Responses, and Thyroid Gene Expression in Rats Fed Diets with Kale Biofortified with 5,7-Diiodo-8-Quinolinol DOI Open Access
Justyna Waśniowska, Ewa Piątkowska, Piotr Pawlicki

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 822 - 822

Опубликована: Янв. 19, 2025

Iodine is a key micronutrient essential for the synthesis of thyroid hormone, which regulates metabolic processes and maintains overall health. Despite its importance, iodine deficiency global health issue, leading to disorders such as goiter, hypothyroidism, developmental abnormalities. Biofortification crops with promising strategy enhance dietary intake, providing an alternative iodized salt. Curly kale (Brassica oleracea var. sabellica) nutrient-rich vegetable high in vitamins A, C, K; minerals; fiber; bioactive compounds antioxidant, anti-inflammatory, detoxifying properties. This study evaluates effects diets containing iodine-biofortified curly (‘Oldenbor F1’ ‘Redbor F1’) on content, tissue levels, various biochemical parameters laboratory rats. The biofortified was enriched 5,7-diiodo-8-quinolinol. content AIN-93G (control) diet non-biofortified did not differ significantly. However, 5,7-diiodo-8-quinolinol showed significantly higher levels compared control diets. Tissue analysis revealed highest concentrations liver kidneys rats fed kale, indicating better bioavailability. Biochemical that had lower total cholesterol (TC) triglyceride (TG) diet. Additionally, improved function markers (ALAT, ASAT) reduced oxidative stress (TBARS). also investigated expression thyroid-related genes (Slc5A5, Tpo, Dio1, Dio2) response kale. results demonstrated significant changes gene expression, adaptive mechanisms presence observed variations uric acid Biofortified supports improves kidney by reducing modulating genetic markers. These findings suggest can effectively increase intake nutritional intervention address promote

Язык: Английский

Comparative Analysis of Iodine Levels, Biochemical Responses, and Thyroid Gene Expression in Rats Fed Diets with Kale Biofortified with 5,7-Diiodo-8-Quinolinol DOI Open Access
Justyna Waśniowska, Ewa Piątkowska, Piotr Pawlicki

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 822 - 822

Опубликована: Янв. 19, 2025

Iodine is a key micronutrient essential for the synthesis of thyroid hormone, which regulates metabolic processes and maintains overall health. Despite its importance, iodine deficiency global health issue, leading to disorders such as goiter, hypothyroidism, developmental abnormalities. Biofortification crops with promising strategy enhance dietary intake, providing an alternative iodized salt. Curly kale (Brassica oleracea var. sabellica) nutrient-rich vegetable high in vitamins A, C, K; minerals; fiber; bioactive compounds antioxidant, anti-inflammatory, detoxifying properties. This study evaluates effects diets containing iodine-biofortified curly (‘Oldenbor F1’ ‘Redbor F1’) on content, tissue levels, various biochemical parameters laboratory rats. The biofortified was enriched 5,7-diiodo-8-quinolinol. content AIN-93G (control) diet non-biofortified did not differ significantly. However, 5,7-diiodo-8-quinolinol showed significantly higher levels compared control diets. Tissue analysis revealed highest concentrations liver kidneys rats fed kale, indicating better bioavailability. Biochemical that had lower total cholesterol (TC) triglyceride (TG) diet. Additionally, improved function markers (ALAT, ASAT) reduced oxidative stress (TBARS). also investigated expression thyroid-related genes (Slc5A5, Tpo, Dio1, Dio2) response kale. results demonstrated significant changes gene expression, adaptive mechanisms presence observed variations uric acid Biofortified supports improves kidney by reducing modulating genetic markers. These findings suggest can effectively increase intake nutritional intervention address promote

Язык: Английский

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