ALTERATIONS IN RAT ILEAL WALL METRICS FOLLOWING ADMINISTRATION OF A COMPLEX OF FOOD CHEMICAL ADDITIVES DURIGN THE EARLY STAGES OF THE EXPERIMENT DOI Open Access
Ya. О. Oliinichenko

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Год журнала: 2024, Номер 24(2), С. 131 - 136

Опубликована: Май 20, 2024

The influence of exogenous factors is a common cause digestive disorders. Food chemical additives are important in the list harmful factors. Despite availability literature data on their adverse effects various systems and organs, information complex impact ileum limited requires further study. present study aimed to determine metric changes ileal wall rats during early stages administration food including monosodium glutamate, sodium nitrite, ponceau 4R. Materials methods. was conducted mature white rats, divided into control experimental groups. group received saline, prepared following standard methodology for 1 4 weeks orally. Material sampling morphometric studies were performed according generally accepted parameters determined: total average thickness serous membrane, muscle layer, submucosal mucosal layers lseparately. Results. Changes indicators found after first week complex. In particular, intestinal increased by 1.51 times compared control; fourth week, this indicator slightly decreased, although it 1.22 higher than (p<0.05). 1.67 1.35 respectively. layer also changed; 1.12 lower one; 1.21 1.34 previous observation period (p<0.05), As muscular group, 1.58 After 1.19 1.33 period. 1.44 group. Conclusion. Thus, introduction leads at experiment due hyperhydration connective tissue, impaired blood circulation, pericellular oedema structural components all membranes.

Язык: Английский

QİDA ƏLAVƏLƏRİ KOMPLEKSİNİN KOQNİTİV FUNKSİYAYA VƏ ŞƏRTİ REFLEKSLƏRİN YARANMA SÜRƏTİNƏ TƏSİRİ DOI
С. М. Білаш, Ya. О. Oliinichenko,

Олена Миколаївна Проніна

и другие.

Azerbajdžanskij medicinskij žurnal, Год журнала: 2024, Номер 1, С. 135 - 141

Опубликована: Март 28, 2024

The article provides information about a research study conducted to establish changes in behavioral reactions of rats at different times use complex chemical food additives (monosodium glutamate, sodium nitrite, Ponceau 4R). was based on administering experimental laboratory subgroups for 1, 4, 8, 12, 16, and 20 weeks once day orally. Cognitive function determined by assessing the formation rate conditioned food-retrieval reflex maze. assessment behavior animals maze showed that initial time introducing (up week 8), obtained results had positive dynamics, with values p<0.05. All evaluated parameters negative trend from 12th study. Significantly (p<0.05), worst indicators were registered after 20th It found consumption leads cognitive dysfunction rats, which characterised impaired memory as well learning ability. Məqalədə siçovullarda kimyəvi qida əlavələri kompleksinin (natrium qlutamat, natrium nitrat, ponso 4 R) müxtəlif müddətlərdə qəbul edildiyi şəraitdə hərəkət tərzinin dəyişikliklərini öyrənmək məqsədilə aparılmış tədqiqat işi haqqında məlumat verilmişdir. Tədqiqat zamanı laboratoriya şəraitində sıçovullara eksperimentlərin qruplarına müvafiq olaraq 16 və həftə ərzində gündə 1 dəfə olmaqla əlavəsi kompleksi yeridilmişdir. Mürəkkəb quruluşlu labirint daxilində qəbuluna qarşı tərzi refleksinin yaranmasına əsasən koqnitiv funksiyanın dəyişmələri qiymətləndirilmişdir. heyvanların qiymətləndirilməsi göstərmişdir ki, əlavələrinin yeridilməsinin ilk müddətlərində (8 həftəyə qədər) alınmış nəticələr müsbət baxımdan etibarlıdır (p<0,05). Eksperimental tədqiqatın 12-ci həftəsindən başlayaraq, öyrənilən parametrlər mənfi istiqamətə meyl etmişdir. Statistik etibarlı (p<0,05) dəyişikliklər isə eksperimental başlanma­sından sonrakı 20-ci həftədə müşahidə edilmişdir. Aydın olmuşdur uzunmüddətli tədbiqi koqnotiv disfunksiyaya səbəb olur. Bu yaddaşın təlim vərdişlərinin yaranmasının pozulması ilə təzahür edir. Пищевые добавки относятся к экзогенным факторам, которые могут быть причиной возникновения когнитивной дисфункции, что может проявляться нарушениями процессов запо­минания иформирования условных рефлексов. Целью исследования было установить изменения поведенческих реакций крыс на разных сроках употребления комплекса химических пищевых добавок (глутамат натрия, нитрит Понсо Исследование базировалось введении экспериментальным подгруппам лабораторных в течение и недель ежедневно однократно перорально. Определение когнитивных функций проведено путем оценки скоростиформирования условного пищедобывающего рефлекса сложном лабиринте. Оценка поведения подопытных животных лабиринте показала, начальных введения (до 8 недель) полученные результаты имели положи­тельную динамику, при значениях p<0,05. Начиная с 12 недели экспериментального все исследуемые параметры отрицательную тенденцию. Достоверно худшие показатели были зарегистрированы после исследования. Было установлено, употребление приводит дисфункции у крыс, которая характеризовалась нарушением функции памяти, а также способности обучению.

Процитировано

3

The Legalome: Nutritional Psychology and Microbiome Sciences at the Intersection of Criminal Justice, Mens Rea, and Mitigation DOI
Susan L. Prescott, Alan C. Logan

Criminal Justice and Behavior, Год журнала: 2024, Номер unknown

Опубликована: Дек. 5, 2024

Recent studies have linked ultra-processed foods with neuropsychiatric disorders, and behaviors of relevance to the criminal justice system. This nutritional epidemiology has been bolstered by mechanistic bench science, human intervention trials, addiction advances in microbiome research. Here, we examine this burgeoning research through lens diminished capacity intent. We use recent legal decisions related auto-brewery syndrome as a way illustrate how intersecting diet gut science is already finding its courtrooms. The legalome—microbiome omics applied forensic psychology—is emerging an important consideration for experts within field behavior. It our contention that are merely prelude ways which combination microbiology psychology will challenge basic assumptions free mens rea.

Язык: Английский

Процитировано

3

Nutrient Inadequacy in Korean Young Adults with Depression: A Case Control Study DOI Open Access
Su-In Yoon,

Hye-Ri Moon,

So Rok Lee

и другие.

Nutrients, Год журнала: 2023, Номер 15(9), С. 2195 - 2195

Опубликована: Май 5, 2023

The role of diet is gaining attention among the modifiable factors associated with depression; thus, this case-control study examined association between nutrition and depression in young Korean adults. Dietary surveys individuals (n = 39) age- gender-matched controls 76) were conducted using food records frequency questionnaires. Men consumed less mushrooms meat, while women significantly grains (p < 0.05). Overall, group energy nutrients, difference was more pronounced men. male had lower nutrient adequacy ratio (NAR) for energy, protein, vitamin A, thiamine, niacin, folate, phosphorus, whereas female NARs B12. a mean both genders. Furthermore, proportion inappropriate intake higher genders group, exhibiting significant differences zinc men riboflavin, C women. Hence, poor high rates inadequacy improper consumption. This suggests that quantity quality meals should be improved depressive symptoms.

Язык: Английский

Процитировано

8

Adherence to Mediterranean Diet Is Associated with Multiple Sclerosis Severity DOI Open Access
Monica Guglielmetti,

Wahidah H. Al-Qahtani,

Cinzia Ferraris

и другие.

Nutrients, Год журнала: 2023, Номер 15(18), С. 4009 - 4009

Опубликована: Сен. 16, 2023

Currently available data suggest that the union of a balanced diet and an overall healthy lifestyle may determine amelioration in several clinical parameters quality life for patients with MS (pwMS). The study objective was to investigate possible difference severity group Italian based on their adherence Mediterranean Diet (MedDiet). Eating habits were collected through validated 110-items Food Frequency Questionnaire, Medi-Lite score used MedDiet evaluation. graded according Herbert's scale, MSSS. 106 classified 3 groups (low/medium/high). Higher associated 6.18 (95% CI: 1.44, 26.59) higher probability having mild-to-moderate MS. When studying single constituents score, none them individually severity. It remains unclear whether effects specific dietary components included impact health status at disease onset or can slow down symptoms due course disease. Future studies are needed reproduce our findings should focus answering latter raised question.

Язык: Английский

Процитировано

8

ALTERATIONS IN RAT ILEAL WALL METRICS FOLLOWING ADMINISTRATION OF A COMPLEX OF FOOD CHEMICAL ADDITIVES DURIGN THE EARLY STAGES OF THE EXPERIMENT DOI Open Access
Ya. О. Oliinichenko

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Год журнала: 2024, Номер 24(2), С. 131 - 136

Опубликована: Май 20, 2024

The influence of exogenous factors is a common cause digestive disorders. Food chemical additives are important in the list harmful factors. Despite availability literature data on their adverse effects various systems and organs, information complex impact ileum limited requires further study. present study aimed to determine metric changes ileal wall rats during early stages administration food including monosodium glutamate, sodium nitrite, ponceau 4R. Materials methods. was conducted mature white rats, divided into control experimental groups. group received saline, prepared following standard methodology for 1 4 weeks orally. Material sampling morphometric studies were performed according generally accepted parameters determined: total average thickness serous membrane, muscle layer, submucosal mucosal layers lseparately. Results. Changes indicators found after first week complex. In particular, intestinal increased by 1.51 times compared control; fourth week, this indicator slightly decreased, although it 1.22 higher than (p<0.05). 1.67 1.35 respectively. layer also changed; 1.12 lower one; 1.21 1.34 previous observation period (p<0.05), As muscular group, 1.58 After 1.19 1.33 period. 1.44 group. Conclusion. Thus, introduction leads at experiment due hyperhydration connective tissue, impaired blood circulation, pericellular oedema structural components all membranes.

Язык: Английский

Процитировано

2