The Role of Probiotics in Modulating the Gut Microbiome in Alzheimer’s Disease: A Review DOI Creative Commons

Yushi Dong,

Xilin Wu, Yumeng Zhang

и другие.

Foods, Год журнала: 2025, Номер 14(9), С. 1531 - 1531

Опубликована: Апрель 27, 2025

Alzheimer’s disease (AD) has emerged as a global public health priority characterized by escalating prevalence and the limited efficacy of current therapeutic approaches. Although pathological complexity AD is well-recognized, its underlying etiology remains incompletely elucidated. Current research highlights bidirectional gut–brain axis (GBA) interaction, wherein gut microbiome perturbations may impair intestinal barrier stability, influence immune responses, blood–brain permeability through microbial metabolite-mediated pathways, thereby contributing to pathophysiology. Notably, probiotics demonstrate potential restoring homeostasis, reinforcing integrity, mitigating neuroinflammatory responses via GBA. This review focuses on investigating alterations in pathogenesis, interaction with GBA, significance pathogenesis. By synthesizing clinical evidence, this aims establish scientific foundation for probiotic-based interventions novel strategy management.

Язык: Английский

The Role of Probiotics in Modulating the Gut Microbiome in Alzheimer’s Disease: A Review DOI Creative Commons

Yushi Dong,

Xilin Wu, Yumeng Zhang

и другие.

Foods, Год журнала: 2025, Номер 14(9), С. 1531 - 1531

Опубликована: Апрель 27, 2025

Alzheimer’s disease (AD) has emerged as a global public health priority characterized by escalating prevalence and the limited efficacy of current therapeutic approaches. Although pathological complexity AD is well-recognized, its underlying etiology remains incompletely elucidated. Current research highlights bidirectional gut–brain axis (GBA) interaction, wherein gut microbiome perturbations may impair intestinal barrier stability, influence immune responses, blood–brain permeability through microbial metabolite-mediated pathways, thereby contributing to pathophysiology. Notably, probiotics demonstrate potential restoring homeostasis, reinforcing integrity, mitigating neuroinflammatory responses via GBA. This review focuses on investigating alterations in pathogenesis, interaction with GBA, significance pathogenesis. By synthesizing clinical evidence, this aims establish scientific foundation for probiotic-based interventions novel strategy management.

Язык: Английский

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