AJP Gastrointestinal and Liver Physiology,
Год журнала:
2020,
Номер
318(4), С. G736 - G747
Опубликована: Фев. 24, 2020
Aging
is
a
risk
factor
in
the
development
of
many
diseases,
including
liver-related
diseases.
The
two
aims
present
study
were
1)
to
determine
how
aging
affects
liver
health
mice
absence
any
interventions
and
2)
if
degenerations
observed
relation
blood
endotoxin
levels
are
critical
aging-associated
degeneration.
Endotoxin
markers
damage,
mitochondrial
dysfunction,
insulin
resistance,
apoptosis
as
well
Toll-like
receptor
4
(Tlr-4)
signaling
cascade
studied
tissue
blood,
respectively,
3-
24-mo-old
male
C57BL/6J
mice.
In
second
set
experiments,
4-mo-old
14-mo-old
female
lipopolysaccharide-binding
protein
(LBP)
−/−
littermates
fed
standard
chow,
dysfunction
assessed.
Plasma
activity
aspartate
aminotransferase
histological
signs
hepatic
inflammation
fibrosis
significantly
higher
old
than
young
animals.
number
neutrophils,
CD8α-positive
cells,
mRNA
expression
also
livers
compared
with
animals,
being
associated
significant
induction
Tlr-4
LBP
peripheral
blood.
Compared
age-matched
littermates,
display
less
senescence
liver.
Taken
together,
our
data
suggest
that,
despite
developed
beginning
that
bacterial
may
play
role
herein.
NEW
&
NOTEWORTHY
Old
age
marked
degeneration,
inflammation,
fibrosis.
Aging-associated
degeneration
elevated
an
4-dependent
cascades
tissue.
Furthermore,
aged
mice,
seem
be
lessened,
supporting
hypothesis
might
decline
