Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Nature Reviews Molecular Cell Biology, Год журнала: 2020, Номер 21(7), С. 363 - 383

Опубликована: Март 30, 2020

Язык: Английский

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Oxidative Stress: A Unifying Paradigm in Hypertension

Canadian Journal of Cardiology, Год журнала: 2020, Номер 36(5), С. 659 - 670

Опубликована: Фев. 25, 2020

The etiology of hypertension involves complex interactions among genetic, environmental, and pathophysiologic factors that influence many regulatory systems. Hypertension is characteristically associated with vascular dysfunction, cardiovascular remodelling, renal stimulation the sympathetic nervous system. Emerging evidence indicates immune system also important activated cells migrate accumulate in tissues promoting inflammation, fibrosis, target-organ damage. Common to these processes oxidative stress, defined as an imbalance between oxidants antioxidants favour leads a disruption oxidation-reduction (redox) signalling control molecular Physiologically, reactive oxygen species (ROS) act molecules cell function through highly regulated redox-sensitive signal transduction. In hypertension, stress promotes posttranslational modification (oxidation phosphorylation) proteins aberrant consequent tissue Many enzymatic systems generate ROS, but NADPH oxidases (Nox) are major sources heart, vessels, kidneys, Expression activity Nox increased responsible for disease. Here we provide unifying concept where common mediator underlying hypertension. We focus on some novel concepts whereby ROS function, aldosterone/mineralocorticoid actions, immunoinflammation, all contributing development

Язык: Английский

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Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights

Redox Biology, Год журнала: 2020, Номер 35, С. 101471 - 101471

Опубликована: Фев. 21, 2020

Antioxidant supplements are commonly consumed by endurance athletes to minimize exercise-induced oxidative stress, with the intention of enhancing recovery and improving performance. There numerous commercially available nutritional that targeted health enthusiasts allegedly possess antioxidant properties. However, most these compounds poorly investigated respect their in vivo redox activity efficacy humans. Therefore, this review will firstly provide a background exercise-related signalling subsequent adaptations skeletal muscle vascular function. The then discuss purported effects for use athletes. N-acetyl cysteine may be benefit over days prior an event; while chronic intake combined 1000 mg vitamin C + E is not recommended during periods heavy training associated muscle. Melatonin, α-lipoic acid appear effective at decreasing markers stress. evidence on performance either lacking or supportive. Catechins, anthocyanins, coenzyme Q10 improve function, however, limited specific sub-populations and/or does translate improved Finally, additional research should clarify potential benefits curcumin post intensive exercise; hampering astaxanthin, selenium A training. Overall, we highlight lack supportive recommend

Язык: Английский

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Protective Effects of Estrogen on Cardiovascular Disease Mediated by Oxidative Stress

Oxidative Medicine and Cellular Longevity, Год журнала: 2021, Номер 2021(1)

Опубликована: Янв. 1, 2021

Perimenopause is an important stage of female senescence. Epidemiological investigation has shown that the incidence cardiovascular disease in premenopausal women lower than men, and postmenopausal significantly higher men. This phenomenon reveals estrogen a definite protective effect on system. In system, oxidative stress considered pathogenesis atherosclerosis, myocardial dysfunction, cardiac hypertrophy, heart failure, ischemia. From perspective stress, plays regulatory role system through receptor, providing strategies for treatment menopausal with diseases.

Язык: Английский

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Accelerating skin regeneration and wound healing by controlled ROS from photodynamic treatment

Inflammation and Regeneration, Год журнала: 2022, Номер 42(1)

Опубликована: Окт. 4, 2022

Abstract Cellular metabolisms produce reactive oxygen species (ROS) which are essential for cellular signaling pathways and physiological functions. Nevertheless, ROS act as “double-edged swords” that have an unstable redox balance between production removal. A little raise of results in cell proliferation enhancement, survival, soft immune responses, while a high level could lead to damage consequently protein, nucleic acid, lipid damages finally death. play important role various pathological circumstances. On the contrary, can show selective toxicity is used against cancer cells pathogens. Photodynamic therapy (PDT) based on three components including photosensitizer (PS), oxygen, light. Upon excitation PS at specific wavelength, PDT process begins leads generation. produced during induce two different pathways. If produces control low ROS, it differentiation. However, excess by causes photo main mechanism treatment. This review summarizes functions living systems describes controllable special focus current ROS-generating therapeutic protocols regeneration wound healing.

Язык: Английский

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Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation

Scientific Reports, Год журнала: 2022, Номер 12(1)

Опубликована: Фев. 23, 2022

Abstract Inflammation triggers pulmonary vascular remodelling. Ferroptosis, a nonapoptotic form of cell death that is triggered by iron-dependent lipid peroxidation and contributes to the pathogenesis several inflammation-related diseases, but its role in hypertension (PH) has not been studied. We examined endothelial ferroptosis PH potential mechanisms. Pulmonary artery cells (PAECs) lung tissues from monocrotaline (MCT)-induced rats were analysed for markers, including peroxidation, labile iron pool (LIP) protein expression glutathione peroxidase 4 (GPX4), ferritin heavy chain 1 (FTH1) NADPH oxidase-4 (NOX4). The effects inhibitor ferrostatin-1 (Fer-1) on remodelling MCT-induced studied vitro vivo. Ferroptosis was observed PAECs vivo characterized decline viability accompanied increases LIP downregulation GPX4 FTH1 upregulation NOX4 expression. High-mobility group box (HMGB1)/Toll-like receptor (TLR4)/NOD-like family pyrin domain containing 3 (NLRP3) inflammasome signalling measured western blotting. These changes significantly blocked Fer-1 administration results suggest plays inhibiting ferroptosis-mediated PAEC loss during progression PH. ferroptosis-induced inflammatory response depended activation HMGB1/TLR4 signalling, which activated NLRP3 are first responses via HMGB1/TLR4/NLRP3 pathway rats. Treating with exploring new treatments based regulation might be promising therapeutic strategies

Язык: Английский

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NOX Dependent ROS Generation and Cell Metabolism

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2086 - 2086

Опубликована: Янв. 20, 2023

Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS, superoxide anion radical (O2·-) is key redox signaling molecule prominently generated by NADPH oxidase (NOX) enzyme family and mitochondrial electron transport chain. Notably, altered balance deregulated are recognized hallmarks cancer involved in malignant progression resistance to drugs treatment. Since oxidative stress metabolism cells strictly intertwined, this review, we focus on emerging roles NOX enzymes as important modulators metabolic reprogramming cancer. The includes seven isoforms different activation mechanisms, widely expressed several tissues. In particular, dissect contribute NOX1, NOX2, NOX4 modulation highlight their potential role new therapeutic target for tumor rewiring.

Язык: Английский

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NADPH oxidase family proteins: signaling dynamics to disease management

Cellular and Molecular Immunology, Год журнала: 2022, Номер 19(6), С. 660 - 686

Опубликована: Май 18, 2022

Язык: Английский

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Multifunctional Integrated Nanozymes Facilitate Spinal Cord Regeneration by Remodeling the Extrinsic Neural Environment

Advanced Science, Год журнала: 2023, Номер 10(7)

Опубликована: Янв. 16, 2023

High levels of reactive oxygen species (ROS) and inflammation create a complicated extrinsic neural environment that dominates the initial post-injury period after spinal cord injury (SCI). The compensatory pathways between ROS limited efficacy modulating above single treatment regimen SCI. Here, novel "nanoflower" Mn

Язык: Английский

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Squalene: More than a Step toward Sterols

Antioxidants, Год журнала: 2020, Номер 9(8), С. 688 - 688

Опубликована: Авг. 2, 2020

Squalene (SQ) is a natural triterpene widely distributed in nature. It metabolic intermediate of the sterol biosynthetic pathway and represents possible target different oxidative stress-related disorders. Growing interest has been focused on SQ’s antioxidant properties, derived from its chemical structure. Strong evidence provided by ex vivo models underline scavenging activity towards free radicals, whereas only few studies have highlighted effect cellular stress. Given role unbalanced radicals both onset progression several cardiovascular diseases, an depth evaluation contribution to defense mechanisms could represent strategic approach dealing with these pathological conditions. At present experimental results overall show double-edged sword squalene diseases function be better elucidated order establish intervention lines features. This review aims summarize current knowledge about endogenous exogenous sources SQ point out controversial physiology.

Язык: Английский

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