Asian Journal of Pharmaceutical and Clinical Research,
Год журнала:
2025,
Номер
unknown, С. 130 - 135
Опубликована: Март 7, 2025
Objectives:
Paclitaxel
(PT)
induced
peripheral
neuropathy
is
associated
with
the
neurotoxic
effects
of
this
chemotherapeutic
drug.
As
a
result,
need
for
natural
substances
that
can
mitigate
neural
toxicity
rising.
This
study
investigated
Neuroprotective
7,3´-dihydroxyflavone
(7,3´-DHF)
on
PT-induced
neurotoxicity
in
SH-SY5Y
neuroblastoma
cells.
Methods:
The
cells
were
exposed
to
1
μM
concentration
PT,
and
protective
various
concentrations
7,3´-DHF
evaluated.
reactive
oxygen
species
(ROS)
level
was
measured
using
confocal
fluorescence
microscopy.
proinflammatory
cytokines,
interleukin-6
(IL-6),
tumor
necrosis
factor-alpha
(TNF-α)
determined
by
enzyme-linked
immunosorbent
assay.
Results:
Treatment
PT
significantly
reduced
cell
viability
19±4.8%.
However,
treatment
PT-exposed
elevated
dose-dependent
manner,
reaching
55.34±3.8%
83.93±4.1%
at
75
μg/mL
100
μg/mL,
respectively.
exposure
ROS
levels
cells,
but
presence
against
toxicity.
In
addition,
lowered
increased
IL-6
TNF-α
exposure.
Conclusion:
effectively
preserved
under
effect
mediated
through
suppression
production
attenuation
cytokine
release,
highlighting
its
potential
as
neuroprotective
agent.
Chemistry & Biodiversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
ABSTRACT
Hinokitiol
(HK),
a
monoterpenoid
that
naturally
occurs
in
plants
belonging
to
the
Cupressaceae
family,
possesses
important
biological
activities,
including
an
anticancer
effect.
This
review
summarizes
its
potential
and
draws
possible
molecular
interventions.
In
addition,
it
evaluates
biopharmaceutical,
toxicological
properties,
clinical
application
of
HK
establish
viability
for
future
advancement
as
dependable
medication.
The
assessment
is
based
on
most
recent
information
available
from
various
databases.
Findings
demonstrate
substantial
therapeutic
advantages
against
diverse
types
cancer
(colon,
cervical,
breast,
bone,
endometrial,
liver,
prostate,
oral,
skin)
through
mechanisms.
induces
oxidative
stress,
cytotoxicity,
apoptosis,
cell‐cycle
arrest
at
G
S
phases,
autophagy
modulation
phosphatidylinositol
3‐kinase
(PI3K)/Akt/mammalian
target
rapamycin
(mTOR),
p38/ERK/MAPK,
nuclear
factor
kappa
B,
c‐Jun
N‐terminal
kinase
signaling
pathways.
Furthermore,
this
compound
exhibits
good
oral
bioavailability
with
excellent
plasma
clearance.
Clinical
uses
without
any
significant
negative
effects.
A
thorough
study
pertinent
data
suggests
may
serve
viable
candidate
developing
novel
therapies.
Consequently,
more
extensive
studies
are
necessary
evaluate
treatment
efficacy,
safety,
long‐term
hazards.
Asian Journal of Pharmaceutical and Clinical Research,
Год журнала:
2025,
Номер
unknown, С. 130 - 135
Опубликована: Март 7, 2025
Objectives:
Paclitaxel
(PT)
induced
peripheral
neuropathy
is
associated
with
the
neurotoxic
effects
of
this
chemotherapeutic
drug.
As
a
result,
need
for
natural
substances
that
can
mitigate
neural
toxicity
rising.
This
study
investigated
Neuroprotective
7,3´-dihydroxyflavone
(7,3´-DHF)
on
PT-induced
neurotoxicity
in
SH-SY5Y
neuroblastoma
cells.
Methods:
The
cells
were
exposed
to
1
μM
concentration
PT,
and
protective
various
concentrations
7,3´-DHF
evaluated.
reactive
oxygen
species
(ROS)
level
was
measured
using
confocal
fluorescence
microscopy.
proinflammatory
cytokines,
interleukin-6
(IL-6),
tumor
necrosis
factor-alpha
(TNF-α)
determined
by
enzyme-linked
immunosorbent
assay.
Results:
Treatment
PT
significantly
reduced
cell
viability
19±4.8%.
However,
treatment
PT-exposed
elevated
dose-dependent
manner,
reaching
55.34±3.8%
83.93±4.1%
at
75
μg/mL
100
μg/mL,
respectively.
exposure
ROS
levels
cells,
but
presence
against
toxicity.
In
addition,
lowered
increased
IL-6
TNF-α
exposure.
Conclusion:
effectively
preserved
under
effect
mediated
through
suppression
production
attenuation
cytokine
release,
highlighting
its
potential
as
neuroprotective
agent.
