Journal of Cellular Physiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
ABSTRACT
Iron
plays
critical
roles
in
many
cellular
functions,
including
energy
production,
metabolism,
and
cell
proliferation.
However,
the
role
of
iron
maintaining
oocyte
quality
remains
unclear.
In
this
study,
DMT1
was
identified
as
a
key
transporter
during
porcine
maturation.
The
results
demonstrated
that
deficiency
led
to
aberrant
meiotic
progression,
accompanied
by
increased
gene
expression
.
Inhibition
resulted
failure
cumulus
expansion
maturation,
along
abnormal
actin
microtubule
assembly.
Furthermore,
loss
function
caused
disruption
mitochondrial
dynamics,
resulting
oxidative
stress
Ca
2+
dyshomeostasis.
Additionally,
absence
activated
PINK1/Parkin‐dependent
mitophagy
oocyte.
These
findings
suggested
played
crucial
safeguarding
protecting
against
iron‐deficiency‐induced
dysfunction
autophagy.
This
study
provided
compelling
evidence
homeostasis
were
for
capacity
Moreover,
hinted
at
potential
novel
therapeutic
target
treating
deficiency‐related
female
reproductive
disorders.
Biology,
Год журнала:
2024,
Номер
14(1), С. 12 - 12
Опубликована: Дек. 27, 2024
Chronic
kidney
disease
(CKD)
is
a
global
health
concern
caused
by
conditions
such
as
hypertension,
diabetes,
hyperlipidemia,
and
chronic
nephritis,
leading
to
structural
functional
injury.
Kidney
fibrosis
common
outcome
of
CKD
progression,
with
abnormal
fatty
acid
oxidation
(FAO)
disrupting
renal
energy
homeostasis
impairments.
This
results
in
maladaptive
repair
mechanisms
the
secretion
profibrotic
factors,
exacerbates
fibrosis.
Understanding
molecular
crucial
for
delaying
progression.
Ferroptosis
type
discovered
an
iron-dependent
lipid
peroxidation-regulated
cell
death.
Notably,
contributes
tissue
organ
fibrosis,
which
correlated
degree
study
aims
clarify
complex
ferroptosis
parenchymal
cells
explore
how
intervention
may
help
alleviate
particularly
addressing
gap
related
metabolism
under
context.
The
goal
provide
new
theoretical
basis
clinically
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10468 - 10468
Опубликована: Сен. 28, 2024
Iron
plays
a
crucial
role
in
various
metabolic
processes.
However,
the
impact
of
5-aminolevulinic
acid
(ALA)
combination
with
iron
chelators
on
metabolism
and
efficacy
ALA-photodynamic
therapy
(PDT)
remain
inadequately
understood.
This
study
aimed
to
examine
effect
thiosemicarbazone
derivatives
during
ALA
treatment
specific
genes
related
metabolism,
particular
emphasis
mitochondrial
genes.
In
our
study,
we
observed
differences
depending
cell
line
studied.
For
HCT116
MCF-7
lines,
most
cases,
decrease
expression
selected
targets
correlated
increase
protoporphyrin
IX
(PPIX)
concentration
photodynamic
effect,
aligning
existing
literature
data.
The
Hs683
showed
different
gene
pattern,
previously
not
described
literature.
this
collected
an
extensive
analysis
variation
occurring
after
application
novel
presented
versatile
effective
compounds
great
potential
for
use
ALA-PDT.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(23), С. 7031 - 7031
Опубликована: Ноя. 21, 2024
:
This
review
aims
to
provide
a
comprehensive
understanding
of
how
HIV
alters
normal
aging
trajectories
in
the
brain,
presenting
HIV-related
molecular
mechanisms
and
pathophysiological
pathways
involved
brain
aging.
The
explores
roles
inflammation,
oxidative
stress,
viral
persistence
highlighting
these
factors
contribute
neuronal
damage
cognitive
impairment
accelerate
Additionally,
it
also
addresses
impact
antiretroviral
therapy
on
biological
markers
associated
with
its
occurrence.
Journal of Cellular Physiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
ABSTRACT
Iron
plays
critical
roles
in
many
cellular
functions,
including
energy
production,
metabolism,
and
cell
proliferation.
However,
the
role
of
iron
maintaining
oocyte
quality
remains
unclear.
In
this
study,
DMT1
was
identified
as
a
key
transporter
during
porcine
maturation.
The
results
demonstrated
that
deficiency
led
to
aberrant
meiotic
progression,
accompanied
by
increased
gene
expression
.
Inhibition
resulted
failure
cumulus
expansion
maturation,
along
abnormal
actin
microtubule
assembly.
Furthermore,
loss
function
caused
disruption
mitochondrial
dynamics,
resulting
oxidative
stress
Ca
2+
dyshomeostasis.
Additionally,
absence
activated
PINK1/Parkin‐dependent
mitophagy
oocyte.
These
findings
suggested
played
crucial
safeguarding
protecting
against
iron‐deficiency‐induced
dysfunction
autophagy.
This
study
provided
compelling
evidence
homeostasis
were
for
capacity
Moreover,
hinted
at
potential
novel
therapeutic
target
treating
deficiency‐related
female
reproductive
disorders.
