L-arginine modified mesoporous bioactive glass with ROS scavenging and NO release for periodontitis treatment

Bioactive Materials, Год журнала: 2025, Номер 48, С. 200 - 216

Опубликована: Фев. 19, 2025

Язык: Английский

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Exosomal non-coding RNAs in the regulation of bone metabolism homeostasis: molecular mechanism and therapeutic potential

Heliyon, Год журнала: 2025, Номер 11(2), С. e41632 - e41632

Опубликована: Янв. 1, 2025

Bone metabolism is a dynamic balance between bone formation and absorption regulated by osteoblasts/osteoclasts. metabolic disorders can lead to disease. Osteoporosis (OP), osteoarthritis (OA) femoral head necrosis (ONFH) are common diseases. At present, the treatment of disease still mainly relieve pain improve joint function. However, surgical does not apply vast majority high-risk groups, including postmenopausal women, patients with diabetes, cirrhosis, etc. Exosomes (Exos) nanoscale membrane vesicles that released almost all cells. Exos rich in variety bioactive substances, such as non-coding RNAs, nucleic acids, proteins lipids. In view structure Exos, it protect biologically active molecules be smoothly delivered target cells involved regulation cell this review, we focus on mechanism function homeostasis mediated exosomal ncRNAs (Exos-ncRNAs), macrophage polarization, autophagy, angiogenesis, signal transduction competing endogenous RNA (ceRNA). We summarized therapeutic strategies potential drugs Exos-ncRNAs Moreover, discussed shortcomings research directions carrier deliver play role.

Язык: Английский

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Comprehensive review of the expanding roles of the carnitine pool in metabolic physiology: beyond fatty acid oxidation

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Март 14, 2025

Traditionally, the carnitine pool is closely related to fatty acid metabolism. However, with increasing research, pleiotropic effects of have gradually emerged. The purpose this review comprehensively investigate emerging understanding role pool, carnitine/acylcarnitines are not only auxiliaries or metabolites oxidation, but also play more complex and diverse roles, including energy metabolism, mitochondrial homeostasis, epigenetic regulation, regulation inflammation immune system, tumor biology, signal transduction, neuroprotection. This provides an overview network synthesis, transport, shuttle, potential be used as communication molecules, biomarkers therapeutic targets for multiple diseases, profound on intercellular communication, metabolic interactions between organs overall health. summarize multidimensional biological beyond its traditional in oxidation systemic mediated by carnitine/acylcarnitine provide new perspectives pharmacological research treatment innovation strategies prevention a variety diseases.

Язык: Английский

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Cannabidiol regulates L-carnitine and butanoic acid metabolism by modulating the gut microbiota to ameliorate collagen-induced arthritis

Phytomedicine, Год журнала: 2024, Номер 136, С. 156270 - 156270

Опубликована: Ноя. 19, 2024

Язык: Английский

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Baicalein disrupts the KEAP1-NRF2 interaction to alleviate oxidative stress injury by inhibiting M1 macrophage polarization

Free Radical Biology and Medicine, Год журнала: 2024, Номер 227, С. 557 - 569

Опубликована: Дек. 17, 2024

Язык: Английский

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