Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Ergothioneine and lactoferrin show antioxidant neuroprotective effects, but their interactive effects underlying mechanisms on Alzheimer's disease are unclear. This study aims to investigate the synergistic effect for a combination of ergothioneine molecular in APP/PS1 transgenic mice neuroblast N2a cells. In mice, improved cognitive function alleviated typical disease's pathological characteristics Aβ aggregation tau phosphorylation. cells, compared with or alone, synergistically increased cell viability by approximately 15% decreased apoptosis 5% flow cytometry. The showed more enhanced efficacy through Keap1/Nrf2-mediated comparison alone. summary, enhances neuroprotection providing foundation development functional foods prevention control disease.

Язык: Английский