Selenium and Selenoproteins in Health

Biomolecules, Год журнала: 2023, Номер 13(5), С. 799 - 799

Опубликована: Май 8, 2023

Selenium is a trace mineral that essential for health. After being obtained from food and taken up by the liver, selenium performs various physiological functions in body form of selenoproteins, which are best known their redox activity anti-inflammatory properties. stimulates activation immune cells important system. also maintenance brain function. supplements can regulate lipid metabolism, cell apoptosis, autophagy, have displayed significant alleviating effects most cardiovascular diseases. However, effect increased intake on risk cancer remains unclear. Elevated serum levels associated with an type 2 diabetes, this relationship complex nonlinear. supplementation seems beneficial to some extent; however, existing studies not fully explained influence Further, more intervention trials needed verify or harmful

Язык: Английский

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Review of cadmium toxicity effects on fish: Oxidative stress and immune responses

Environmental Research, Год журнала: 2023, Номер 236, С. 116600 - 116600

Опубликована: Июль 8, 2023

Язык: Английский

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Understanding thrombosis: the critical role of oxidative stress

Hematology, Год журнала: 2024, Номер 29(1)

Опубликована: Янв. 7, 2024

Thrombosis, a leading contributor to global health burden, is complex process involving the interplay of various cell types, including vascular endothelial cells, platelets, and red blood cells. Oxidative stress, characterized by an overproduction reactive oxygen species (ROS), can significantly impair function these thus instigating cascade events thrombus formation. In this review, we comprehensively explore role oxidative stress within its mechanistic contribution thrombogenesis, application therapy in inhibiting thrombosis. By dissecting intricacies impact on thrombosis, underscore potential as viable therapeutic target. Therefore, further research direction warranted enhance our understanding management thrombotic disorders.

Язык: Английский

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Signalling regulation of reactive oxygen species in fish inflammation

Reviews in Aquaculture, Год журнала: 2024, Номер 16(3), С. 1266 - 1285

Опубликована: Янв. 29, 2024

Abstract Reactive oxygen species (ROS), which are key cellular signalling molecules, reactive chemicals containing oxygen. Cell survival or death is a critical issue in the inflammatory response. Accumulation of ROS involves generation and scavenging, determine homeostasis. Understanding roles modulating response fish vital for helping protect from damage water pollutants harsh environmental conditions. ROS‐related genes pathways relatively conserved but vary among different species. Recent frequent incidences diseases have posed considerable challenge to large‐scale aquaculture. important stress perception, integration diverse stress‐responsive networks, activation animal defence mechanisms, frequently occur during inflammation fish. This review summarises recent studies on Furthermore, it examines relationship between may contribute understanding underlying mechanisms by regulate provide suggestions sustainable development

Язык: Английский

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Green tea polyphenols inhibit TBBPA-induced lung injury via enhancing antioxidant capacity and modulating the NF-κB pathway in mice

Food & Function, Год журнала: 2024, Номер 15(7), С. 3411 - 3419

Опубликована: Янв. 1, 2024

Tetrabromobisphenol A (TBBPA) is a global pollutant. When TBBPA absorbed by the body through various routes, it can have wide range of harmful effects on body. Green tea polyphenols (GTPs) act as antioxidants, resisting toxic animals. The and mechanisms GTP oxidative stress, inflammation apoptosis in mouse lung are unknown. Therefore, we established vivo vitro models exposure antagonism using C57 mice A549 cells examined expression factors related to autophagy, apoptosis. results study showed that increase reactive oxygen species (ROS) levels after decreased autophagy-related Beclin1, LC3-II, ATG3, ATG5, ATG7 ATG12 increased p62; stress inhibits autophagy levels. pro-inflammatory IL-1β, IL-6 TNF-α anti-inflammatory factor IL-10 activation NF-κB p65/TNF-α pathway. Bax, caspase-3, caspase-7 caspase-9 Bcl-2 activate apoptosis-related pathways. addition attenuated levels, restored inhibition reduced Our suggest attenuate modulating ROS, reducing increasing attenuating cells. These provide fundamental information for exploring antioxidant mechanism further studying TBBPA.

Язык: Английский

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Baicalin n-butyl ester alleviates inflammatory bowel disease and inhibits pyroptosis through the ROS/ERK/P-ERK/NLRP3 pathway in vivo and in vitro

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 186, С. 118012 - 118012

Опубликована: Апрель 2, 2025

Язык: Английский

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Tetrabromobisphenol a and its alternative tetrachlorobisphenol a induce oxidative stress, lipometabolism disturbance, and autophagy in the liver of male Pelophylax nigromaculatus

The Science of The Total Environment, Год журнала: 2023, Номер 903, С. 166421 - 166421

Опубликована: Авг. 23, 2023

Язык: Английский

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Quercetin alleviates DEHP exposure-induced pyroptosis and cytokine expression changes in grass carp L8824 cell line by inhibiting ROS/MAPK/NF-κB pathway

Fish & Shellfish Immunology, Год журнала: 2023, Номер 143, С. 109223 - 109223

Опубликована: Ноя. 14, 2023

Язык: Английский

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Environmentally relevant exposure to tetrabromobisphenol A induces reproductive toxicity via regulating glucose-6-phosphate 1-dehydrogenase and sperm activation in Caenorhabditis elegans

The Science of The Total Environment, Год журнала: 2023, Номер 907, С. 167820 - 167820

Опубликована: Окт. 17, 2023

Язык: Английский

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The relationship between selenium and viral diseases

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Abstract Selenium (Se) is a trace element that fulfills vital functions in the organism. Over past few years, numerous studies have revealed profound connection between and its therapeutic potential addressing various viral infectious diseases. can boost activity of immune cells counteract oxidative damage caused by free radicals to prevent replication viruses. Studies shown protects against wide range viruses such as DNA viruses, hepatitis B virus, RNA human immunodeficiency virus coxsackie virus. probably one research directions for antiviral drugs future. This review summarizes use therapy progress.

Язык: Английский

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