Abstract
The
Nyctereutes
procyonoides
is
highly
regarded
in
the
farming
and
leather
industries
because
of
high
value
its
fur,
which
renders
artificial
feeding
a
crucial
aspect.
However,
high-fat
diets
have
always
been
associated
with
variety
digestive
disorders.
This
study
aimed
to
investigate
impact
on
gut
microbiota
mechanisms
damage
.
16S
rRNA
sequencing
demonstrated
that
caused
diarrhea
intestinal
through
alterations
microbiota:
decrease
abundance
Firmicutes,
an
increase
Proteobacteria
Actinobacteria
,
Enterococcaceae
Escherichia
coli-Shigella
Clostridium
Lactobacillus
Subsequently,
changes
metabolic
pathways,
such
as
amino
fatty
acid
were
identified
by
KEGG
COG
enrichment
analysis,
TLR4/NF-κB/NLRP3
inflammatory
signaling
pathway
was
shown
be
activated
diets.
In
addition,
lead
accumulation
ROS
MDA
reduce
activity
antioxidant
enzymes
GSH-PX
SOD.
Correspondingly,
levels
proinflammatory
cytokines
(IL-6,
IL-1β
TNF-α)
significantly
increased,
apoptosis
necrosis
pathways
colonic
cells
detected,
causing
dramatic
expression
tight
junction
proteins
(Occludin,
E-cadherin,
ZO-1
ZO-2).
conclusion,
altered
structure
community
led
colon
damage.
provides
new
insights
into
health
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