Journal of Fish Diseases, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

ABSTRACT Chemokines play a crucial role in immune responses by facilitating the migration of cells expressing corresponding chemokine receptors along concentration gradients. Photobacterium damselae subsp. Damselae (PDD) and Nocardia seriolae (NS) are known to induce substantial mortality silver pomfret populations, yet there exists dearth research regarding response CCL s PDD‐ or NS‐infected pomfret. In our investigation, we identified 10 PaCCL s, which include one fish‐specific ( PaCCL44 ). Phylogenetic analysis revealed considerable diversity types copy numbers among various teleost fishes. Notably, lacks specific genes, with most exhibiting heightened expression levels immune‐related organs such as spleen kidney, some being expressed mucosal like skin gills. Transcriptome conducted on infected NS PDD elucidated that changes primarily manifested during initial stages infection, shifting kidney later stages. Conversely, following infection predominantly occurred kidney. vitro studies using cell lines demonstrated an early peak followed gradual decline treatment rapid diminishment treatment. These findings suggest support innate immunity pomfret, potentially chemotactic effects stages, synergistic action PaCCL4 PaCCL25 , serving direct antibacterial agents. invasion is characterised chronic affecting multiple organs, whereas inflicts severe damage PaCCL19a PaCCL19b PDD, their may decrease due escape. data offer insights into understanding mechanism underlying gene family provide theoretical underpinnings for fish culture practices.

Язык: Английский