Robust multi-view fuzzy clustering with exponential transformation and automatic view weighting

Knowledge-Based Systems, Год журнала: 2025, Номер unknown, С. 113314 - 113314

Опубликована: Март 1, 2025

Язык: Английский

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Robust vector-weighted and matrix-weighted multi-view hard c-means clustering

Intelligent Systems with Applications, Год журнала: 2025, Номер 25, С. 200470 - 200470

Опубликована: Янв. 5, 2025

Язык: Английский

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Genomic Structural Equation Modeling Elucidates the Shared Genetic Architecture of Allergic Disorders

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Background The intricate shared genetic architecture underlying allergic disorders—including asthma, atopic dermatitis, contact rhinitis, conjunctivitis, urticaria, anaphylaxis, and eosinophilic esophagitis—remains incompletely characterized. Methods Our study employed genomic structural equation modeling (Genomic SEM) to define the common factor representing of disorders. Coupled with diverse post-GWAS analytical methods, we aimed discover susceptible loci investigate associations external traits. Furthermore, explored enriched pathways, cellular layers, elements, investigated putative plasma protein biomarkers. Polygenic risk score (PRS) analyses, leveraging our integrated GWAS data, were conducted assess chromosomal-level for Results A well-fitted SEM revealing We identified a total 2038 genome-wide significant SNP (p < 5e-8), including 31 previously unreported loci. Fine-mapping variants gene sets pinpointed 2 causal candidate genes. Genetic correlation analyses further illuminated multiple traits, notably psychiatric Preliminary findings four Conclusion Notably, this presents first comprehensive characterization disorders through analysis an unmeasured composite phenotype, providing novel insights into etiological pathways across these conditions.

Язык: Английский

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Genomic structural equation modeling elucidates the shared genetic architecture of allergic disorders

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 15, 2025

The intricate shared genetic architecture underlying allergic disorders-including asthma, atopic dermatitis, contact rhinitis, conjunctivitis, urticaria, anaphylaxis, and eosinophilic esophagitis-remains incompletely characterized. Our study employed genomic structural equation modeling (Genomic SEM) to define the common factor representing of disorders. Coupled with diverse post-GWAS analytical methods, we aimed discover susceptible loci investigate associations external traits. Furthermore, explored enriched pathways, cellular layers, elements, investigated putative plasma protein biomarkers. Polygenic risk score (PRS) analyses, leveraging our integrated GWAS data, were conducted assess chromosomal-level for A well-fitted SEM revealing We identified a total 2038 genome-wide significant SNP (p < 5e-8), including 31 previously unreported loci. Fine-mapping variants gene sets pinpointed 2 causal candidate genes. Genetic correlation analyses further illuminated multiple traits, notably psychiatric Preliminary findings four Notably, this presents first comprehensive characterization disorders through analysis an unmeasured composite phenotype, providing novel insights into etiological pathways across these conditions.

Язык: Английский

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Auto feature weighted c-means type clustering methods for color image segmentation

Engineering Applications of Artificial Intelligence, Год журнала: 2025, Номер 153, С. 110768 - 110768

Опубликована: Апрель 22, 2025

Язык: Английский

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SFD-YOLO: A novel framework for subsidence funnels detection in China based on large-scale SAR interferograms

International Journal of Applied Earth Observation and Geoinformation, Год журнала: 2025, Номер 140, С. 104605 - 104605

Опубликована: Май 19, 2025

Язык: Английский

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Establishment of distance measures on Fermatean fuzzy sets and their applications in pattern classification and multi-attribute decision-making

Deleted Journal, Год журнала: 2025, Номер 7(6)

Опубликована: Май 23, 2025

Язык: Английский

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S1PR3 inhibition impairs cell cycle checkpoint via the AKT/WEE1 pathway in oral squamous cell carcinoma

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Май 23, 2025

Sphingosine-1-phosphate receptor 3 (S1PR3) has been implicated in promoting tumor progression various cancers. However, the role and molecular mechanisms of S1PR3 oral squamous cell carcinoma (OSCC) remain poorly understood. The aims this study were to investigate function OSCC its potential as a therapeutic target. expression was determined through qPCR, Western blotting analysis, immunohistochemistry (IHC), TCGA database. correlation between clinical prognosis analyzed using database IHC. effects on proliferation cycle investigated CCK-8 assay, colony formation EdU incorporation xenograft mouse model. which affects explored RNA-seq array. combining antagonist with cisplatin growth examined assays. overexpressed upregulation correlated unfavorable clinicopathological characteristics adverse prognosis. Targeting reduced AKT phosphorylation, led downregulation WEE1, kinase involved regulation. This resulted reducing CDC2 disrupting G2/M checkpoint inhibiting proliferation. Furthermore, combination exhibited synergistic inhibitory when combined cisplatin. These findings reveal critical for regulating via AKT/WEE1/CDC2 pathway, thus offering basis developing treatment strategies patients.

Язык: Английский

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A new evidential divergence measure for multisensor data fusion and its application in fault diagnosis

International Journal of General Systems, Год журнала: 2025, Номер unknown, С. 1 - 31

Опубликована: Июнь 5, 2025

Язык: Английский

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