Academia molecular biology and genomics., Год журнала: 2024, Номер 1(1)
Опубликована: Дек. 27, 2024
Язык: Английский
Biofuel Research Journal, Год журнала: 2024, Номер 11(01), С. 2040 - 2064
Опубликована: Март 1, 2024
Using oleaginous microbial lipid-based biorefinery from lignocellulosic biomass (LCB) to produce fermentative bioenergy (i.e., biodiesel) represents an innovative second-generation fuel production technology. These lipids are predominantly intracellular triglycerides that accumulate through the metabolism of sugars in fermentation following pretreatment and enzymatic hydrolysis LCB. This review investigates recent advances lipid LCB, focusing on factors influencing lead producers, different methods physical, chemical, biological, combined pretreatment), approaches, novel bioprocessing strategies microbes-specific model specific), engineering techniques microbes genetic metabolic alterations). The study demonstrates yeasts can synthesize significantly higher quantities when incorporated into system, known as separated production, various methods. Interestingly, CRISPR is found be most suitable way genetically metabolically for increased synthesis. also explores economically viable addressing associated challenges, outlines future directions, including comprehensive techno-economic life cycle assessments. offers invaluable insights highlighting potential significant technological environmental enhancements ongoing research development efforts.
Язык: Английский
Процитировано
13
Marine Drugs, Год журнала: 2024, Номер 22(2), С. 80 - 80
Опубликована: Фев. 6, 2024
The products of oleaginous microbes, primarily lipids, have gained tremendous attention for their health benefits in food-based applications as supplements. However, this emerging biotechnology also offers a neuroprotective treatment/management potential various diseases that are seldom discussed. Essential fatty acids, such DHA, known to make up the majority brain phospholipid membranes and integral cognitive function, which forms an important defense against Alzheimer’s disease. Omega-3 polyunsaturated acids been shown reduce recurrent epilepsy seizures used cancer therapies. ratio omega-3 omega-6 PUFAs is essential maintaining physiological function. Furthermore, lipids employed effective vehicle deliver drugs treatment diseases. Lipid nanoparticle technology, pharmaceuticals cosmeceuticals, has recently emerged biocompatible, biodegradable, low-toxicity, high-stability means drug delivery address drawbacks associated with traditional medicine methods. This review aims highlight dual benefit offer good disease prevention neurological
Язык: Английский
Процитировано
7
Biotechnology for Biofuels and Bioproducts, Год журнала: 2024, Номер 17(1)
Опубликована: Фев. 24, 2024
Abstract
Background
Biodiesel,
an
emerging
sustainable
and
renewable
clean
energy,
has
garnered
considerable
attention
as
alternative
to
fossil
fuels.
Although
lipases
are
promising
catalysts
for
biodiesel
production,
their
efficiency
in
industrial-scale
application
still
requires
improvement.
Results
In
this
study,
a
novel
strategy
multi-site
mutagenesis
the
binding
pocket
was
developed
via
FuncLib
(for
mutant
enzyme
design)
Rosetta
Cartesian_ddg
free
energy
calculation)
improve
reaction
rate
yield
of
lipase-catalyzed
production.
Thermomyces
lanuginosus
lipase
(TLL)
with
high
activity
thermostability
obtained
using
Pichia
pastoris
expression
system.
The
specific
activities
mutants
M11
M21
(each
5
4
mutations)
were
1.50-
3.10-fold
higher,
respectively,
than
those
wild-type
(wt–TLL).
Their
corresponding
melting
temperature
profiles
increased
by
10.53
6.01
°C,
$$T_{50}^{15}$$
Язык: Английский
Процитировано
7
Fuel, Год журнала: 2024, Номер 366, С. 131267 - 131267
Опубликована: Фев. 28, 2024
Язык: Английский
Процитировано
6
Polymers for Advanced Technologies, Год журнала: 2024, Номер 35(12)
Опубликована: Дек. 1, 2024
ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.
Язык: Английский
Процитировано
4
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 485 - 504
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 147 - 167
Опубликована: Янв. 1, 2025
Процитировано
0
Green Energy and Environmental Technology, Год журнала: 2025, Номер 4
Опубликована: Фев. 28, 2025
As of 2023, coal, oil, and natural gas, which are non-renewable fossil fuels, account for about 80% the world’s energy consumption. This underscores pressing necessity alternative sources in light worsening climate crisis. Apart from problems, this review evaluates potential microbial fuel cells biofuel production, contributes to just 10–20% total consumption due its relatively low environmental impact. The aim systematic is elucidate their role producing a range bio-based including biogas, biodiesel, bioethanol, biobutanol. findings categorized into ten main areas: biomass conversion techniques, substrates strains, design components cells, strain improvement through metabolic engineering, enhancements nanomaterials advantages disadvantages biofuels, integration biorefineries, applications, challenges limitations, future trends cell technology. also promise as sustainable eco-friendly option bioenergy emphasizing need advancements efficiency compete with conventional fuels. Harnessing innovative strategies pertaining technology (MFCs) can potentially transform generation more commercially viable practice, positively impacting conservation public health.
Язык: Английский
Процитировано
0
ACS Sustainable Chemistry & Engineering, Год журнала: 2025, Номер unknown
Опубликована: Март 29, 2025
Язык: Английский
Процитировано
0
eFood, Год журнала: 2025, Номер 6(2)
Опубликована: Апрель 1, 2025
ABSTRACT Extreme exploitation of petroleum fuels has raised concerns around global warming due to increased greenhouse gas emissions, which by the year 2040 are expected rise 43 billion metric tons. Biofuels have gained popularity in recent years because their renewable and environmentally friendly prospects. Second‐generation biodiesel is generated from nonedible raw materials such as food waste, suggested lesser negative impacts on environment does not threaten security. Edible fruit waste (7.65 kg/person) edible vegetable (16 highest contribution 38% waste. Annually, this corresponds 15.78 m 2 cropland usage, 1.358 kg CO equivalent, 232.87 g nitrogen 3810.6 L freshwater 38.544 phosphorus usage per person for agricultural production. FVW includes peels, seeds, crops, leaves, straw, stems, roots, or tubers. This can be utilized feedstock biofuel instead burning, dumping, landfilling, leads economic, environmental, health issues water‐borne diseases, respiratory lung diseases. Converting lignocellulosic mass into green energy including biogas, bioethanol, biohydrogen help management while also contributing carbon‐neutral model. Past studies shown potential using generation, jet fuels, general diesel engines. review focuses latest advances production technology, with an emphasis new pretreatments, technologies, works improve biomass.
Язык: Английский
Процитировано
0