Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives DOI Creative Commons
David Llères,

A. Gizzi,

Marcelo Nöllmann

и другие.

Current Opinion in Cell Biology, Год журнала: 2025, Номер 95, С. 102527 - 102527

Опубликована: Май 16, 2025

This review explores recent emerging insights into enhancer action, focusing on underexplored aspects such as the physical size of regulatory elements, stochasticity transcription factor binding and chromatin structure, role nonlinear processes in reconciling longstanding discrepancies between theoretical models experimental observations. Together, these provide a nuanced view biology, highlighting complexity gene regulation need for innovative methodologies to further decode mechanisms.

Язык: Английский

Editorial overview: Emerging perspectives in genome architecture and gene regulation DOI
Marcelo Nöllmann, Anders S. Hansen

Current Opinion in Genetics & Development, Год журнала: 2025, Номер 93, С. 102355 - 102355

Опубликована: Май 12, 2025

Язык: Английский

Процитировано

0

Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives DOI Creative Commons
David Llères,

A. Gizzi,

Marcelo Nöllmann

и другие.

Current Opinion in Cell Biology, Год журнала: 2025, Номер 95, С. 102527 - 102527

Опубликована: Май 16, 2025

This review explores recent emerging insights into enhancer action, focusing on underexplored aspects such as the physical size of regulatory elements, stochasticity transcription factor binding and chromatin structure, role nonlinear processes in reconciling longstanding discrepancies between theoretical models experimental observations. Together, these provide a nuanced view biology, highlighting complexity gene regulation need for innovative methodologies to further decode mechanisms.

Язык: Английский

Процитировано

0