Angiotensin-converting enzyme insertion/deletion polymorphism as a potential risk factor of congenital heart disease: insights from a tertiary pediatric cardiac care centre from North India DOI Open Access
Shadab Ahamad, Prachi Kukshal, Ajay Kumar

и другие.

International Journal of Scientific Reports, Год журнала: 2024, Номер 10(12), С. 422 - 431

Опубликована: Ноя. 25, 2024

Background: Our study aims to elucidate the genetic influence of angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism on congenital heart disease (CHD) in a north Indian cohort. Methods: 667 CHD cases, including 433 individuals with parental data and 104 controls were enrolled genotyped by polymerase chain reaction. Case-control association, transmission test, association patients' parents' clinical parameters ACE I/D explored. Results: findings highlight significant associations, notably increased risk conferred DD genotype females (p=0.036; OR=1.68), its correlation abnormal hemoglobin levels (p=0.049; impact primigravida (p=0.05). Conversely, II was found significantly elevate offspring tobacco-consuming fathers 2.5-fold (p=0.029). Notably, cyanotic cases exhibited heightened prevalence mutations (p=0.059), tetralogy Fallot (TOF) showing strongest (p=0.024). Additionally, genotype's involvement conditions such as stenosis (p=0.026) pulmonary artery hypertension (PAH) (p=0.05) underscores relevance. The parent origin test showed maternal D allele combined (p=0.037) acyanotic (p=0.039) paternal ventricular septal defect (p=0.021). Conclusions: This is first from India possibly only globally that reports between CHD, highlighting importance factors susceptibility.

Язык: Английский

Association of Epistatic Effects of lncRNA GAS5, miR-146a, IRAK-1, and miR-155 Genetic Variants with Multiple Sclerosis Risk and Severity DOI Creative Commons
Ghada Ayeldeen, Olfat Shaker,

Mohammed Gomaa

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Язык: Английский

Процитировано

0
Expression profile and functional analysis of miR-301b in patients with breast cancer: A bioinformatics, biochemical, and histopathological study DOI
Mohamed Taha, Einas Yousef,

Ahmed Nawar Badr

и другие.

Pathology - Research and Practice, Год журнала: 2024, Номер 262, С. 155536 - 155536

Опубликована: Авг. 12, 2024

Язык: Английский

Процитировано

2
Angiotensin-converting enzyme insertion/deletion polymorphism as a potential risk factor of congenital heart disease: insights from a tertiary pediatric cardiac care centre from North India DOI Open Access
Shadab Ahamad, Prachi Kukshal, Ajay Kumar

и другие.

International Journal of Scientific Reports, Год журнала: 2024, Номер 10(12), С. 422 - 431

Опубликована: Ноя. 25, 2024

Background: Our study aims to elucidate the genetic influence of angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphism on congenital heart disease (CHD) in a north Indian cohort. Methods: 667 CHD cases, including 433 individuals with parental data and 104 controls were enrolled genotyped by polymerase chain reaction. Case-control association, transmission test, association patients' parents' clinical parameters ACE I/D explored. Results: findings highlight significant associations, notably increased risk conferred DD genotype females (p=0.036; OR=1.68), its correlation abnormal hemoglobin levels (p=0.049; impact primigravida (p=0.05). Conversely, II was found significantly elevate offspring tobacco-consuming fathers 2.5-fold (p=0.029). Notably, cyanotic cases exhibited heightened prevalence mutations (p=0.059), tetralogy Fallot (TOF) showing strongest (p=0.024). Additionally, genotype's involvement conditions such as stenosis (p=0.026) pulmonary artery hypertension (PAH) (p=0.05) underscores relevance. The parent origin test showed maternal D allele combined (p=0.037) acyanotic (p=0.039) paternal ventricular septal defect (p=0.021). Conclusions: This is first from India possibly only globally that reports between CHD, highlighting importance factors susceptibility.

Язык: Английский

Процитировано

0