Molecular Biology Reports, Год журнала: 2024, Номер 51(1)
Опубликована: Авг. 10, 2024
Язык: Английский
Pharmacological Research, Год журнала: 2024, Номер 204, С. 107200 - 107200
Опубликована: Май 6, 2024
Targeting specific molecular drivers of tumor growth is a key approach in cancer therapy. Among these targets, the low-density lipoprotein receptor-related protein 6 (LRP6), vital component Wnt signaling pathway, has emerged as an intriguing candidate. As cell-surface receptor and co-receptor, LRP6 frequently overexpressed various types, implicating its pivotal role driving progression. The pursuit target for treatment gained substantial traction, offering promising avenue therapeutic intervention. Here, this comprehensive review explores recent breakthroughs our understanding LRP6's functions underlying mechanisms, providing profound discussion involvement pathogenesis drug resistance. Importantly, we go beyond discussing by diverse potential approaches targeting enigmatic protein. These encompass wide spectrum, including pharmacological agents, natural compounds, non-coding RNAs, epigenetic factors, proteins, peptides that modulate expression or disrupt interactions. In addition, also discussed challenges associated with developing inhibitors their advantages over inhibitors, well drugs have entered phase II clinical trials. By shedding light on innovative strategies, aim to underscore significance valuable multifaceted treatment, igniting enthusiasm further research facilitating translation into applications.
Язык: Английский
Процитировано
10
International Journal of Oncology, Год журнала: 2025, Номер 66(2)
Опубликована: Янв. 14, 2025
Circular (circ)RNAs participate in colorectal cancer (CRC) occurrence and progression. However, the role of hsa_circ_0004662 (circ_0004662) CRC remains unknown. Reverse transcription‑quantitative PCR noted high expression circ_0004662 compared with normal epithelial cells. knockdown inhibited migration cells vitro vivo; would healing Transwell assays showed that overexpression contributed to migration. Nuclear cytoplasmic analysis fluorescence situ hybridization revealed localization nucleus cytoplasm. CircRNADB databases predicted exhibited translational potential liquid chromatography‑mass spectrometry (LC‑MS) pull‑down products suggested bound multiple ribosomal subunits. peptide 149aa translated by circ_0004662, a molecular weight ~17 kDa were not detected. Nevertheless, LC‑MS indicated proteins. Immunoprecipitation RNA‑binding proteins heterogeneous nuclear ribonucleoprotein M (hnRNPM) hnRNPM interference decreased expression, thereby affecting In summary, was significantly upregulated CRC. As non‑coding RNA, it may promote progression binding hnRNPM, which serve as target for treating
Язык: Английский
Процитировано
0
EBioMedicine, Год журнала: 2025, Номер 114, С. 105638 - 105638
Опубликована: Март 19, 2025
Язык: Английский
Процитировано
0
Seminars in Oncology, Год журнала: 2025, Номер 52(2), С. 152340 - 152340
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
The Kaohsiung Journal of Medical Sciences, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Abstract This study aimed to explore the mechanism of insulin‐like growth factor 2 mRNA‐binding protein (IGF2BP2) affecting proliferation breast cancer (BC) cells. The expression IGF2BP2, circRNA ring finger 20 (circRNF20), and cell division cycle‐associated 4 (CDCA4) in human BC cells normal epithelial was detected via RT‐qPCR or Western blotting. After IGF2BP2 altered, CCK‐8 assay, colony formation EdU staining were performed evaluate changes RNA immunoprecipitation (RIP) assay used analyze binding circRNF20 HuR, as well HuR CDCA4. pull‐down confirmed interaction between HuR. stability tested after treatment with actinomycin D. A nude mouse xenograft tumor model established validate effect vivo. circRNF20, CDCA4 highly expressed Silencing decreased ability Mechanistically, prevented degradation, thereby promoting increasing overexpression abolished inhibitory silencing on proliferation. In conclusion, prevents its thus facilitating HuR/CDCA4 axis.
Язык: Английский
Процитировано
0
Molecular Carcinogenesis, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
ABSTRACT Increasing numbers of studies have elucidated the emerging roles circular RNA (circRNA) in cancer progression. However, function circRNAs modulating their parental genes ovarian remains poorly understood. In this study, we identified that circ_0044362, a circRNA derived from homeobox B4 (HOXB4), significantly promotes expression its gene HOXB4 cancer. Functionally, circ_0044362 malignant phenotypes cells. Further analysis revealed facilitates transcriptional activation by directly guiding U1 small nuclear ribonucleoprotein (snRNP) to promoter region, thereby enhancing oncogenic behaviors Furthermore, positively regulates runt‐related transcription factor 1 (RUNX1) expression, with RUNX1 serving as promote insulin‐like growth binding protein‐3 (IGFBP3). Notably, inhibitors either HOXB4, RUNX1, or IGFBP3 could reverse activity mediated circ_0044362. Collectively, our findings reveal involvement circ_0044362/HOXB4 pathway progression and provide potential therapeutic strategies for treatment.
Язык: Английский
Процитировано
0
Phytotherapy Research, Год журнала: 2025, Номер unknown
Опубликована: Март 29, 2025
Non-coding RNAs (ncRNAs) are a distinctive class of RNA transcripts that have received extensive attention from the global scientific community due to their intricate and important roles in tumor malignancy. The dysregulated expression ncRNAs is closely associated with progression different types cancer, suggesting serve as key regulatory factors modulate numerous cancer biomarkers. complex interactions between ncRNAs, including microRNAs (miRNAs), long non-coding (lncRNAs), circular (circRNAs), well mRNAs or RNA-binding proteins, orchestrate many biological processes tumors. Natural products, obtained dietary medicinal sources, extremely safe stable therapeutic outcomes. These products can regulate effectively inhibiting cell growth proliferation even triggering death. This ability highlights they reduce burden enhance clinical outcomes for patients. In this review we discussed mechanisms underlying ncRNAs-mediated regulation systematically highlighted diverse antitumor applications natural specifically control ncRNAs. We aimed provide novel perspectives methods field anticancer research, focusing on application products.
Язык: Английский
Процитировано
0
Leukemia, Год журнала: 2025, Номер unknown
Опубликована: Апрель 2, 2025
Язык: Английский
Процитировано
0
Radiation Oncology, Год журнала: 2024, Номер 19(1)
Опубликована: Июнь 26, 2024
Abstract Background At present, it has been found that many patients have acquired resistance to radiotherapy, which greatly reduces the effect of radiotherapy and further affects prognosis. CircRNAs is involved in regulation radiosensitivity kinds tumor cells. Therefore, main purpose this study explore regulatory CircRNA_101491 on ESCC its related mechanism. Methods We established radiation-resistant cell line (KYSE150R cell) by gradient dose method, tested difference KYSE150 between KYSE150R parent vitro. Then, after knocking down expression CircRNA_101491, a series vitro experiments were conducted verify effects phenotype cells, analyzed In addition, we also used model transplanted nude mice investigate vivo. Results According experiments, confirmed cells lost epithelial obtained interstitial cell-like phenotype, was highly expressed will lift inhibition miR-125a-5p, then reverse process EMT, accelerate apoptosis, thus play role radiosensitization. The vivo experiment showed could enhance ESCC. Conclusion conclusion, interfering with can relieve
Язык: Английский
Процитировано
2
Translational Cancer Research, Год журнала: 2024, Номер 13(2), С. 1139 - 1149
Опубликована: Фев. 1, 2024
Background and Objective: Breast cancer is presently the most prevalent leading cause of cancer-related deaths in women worldwide. Circular RNA (circRNA) a class closed circRNAs lacking 5'-end cap structure 3'-end polyA tail, which highly stable widely involved variety pathophysiological processes such as cell proliferation, differentiation, apoptosis. In recent years, accumulating studies have shown that play an important role development prognosis breast cancer, but there are fewer literature reviews on their intrinsic molecular mechanisms aim this study.
Язык: Английский
Процитировано
1