The Pathophysiological Underpinnings of Gamma-Band Alterations in Psychiatric Disorders
Life,
Год журнала:
2024,
Номер
14(5), С. 578 - 578
Опубликована: Апрель 30, 2024
Investigating
the
biophysiological
substrates
of
psychiatric
illnesses
is
great
interest
to
our
understanding
disorders’
etiology,
identification
reliable
biomarkers,
and
potential
new
therapeutic
avenues.
Schizophrenia
represents
a
consolidated
model
γ
alterations
arising
from
aberrant
activity
parvalbumin-positive
GABAergic
interneurons,
whose
dysfunction
associated
with
perineuronal
net
impairment
neuroinflammation.
This
pathogenesis
supported
by
molecular,
cellular,
functional
evidence.
Proof
for
oscillations
their
underlying
mechanisms
has
also
been
reported
in
bipolar
disorder
an
emerging
topic
major
depressive
disorder.
Although
evidence
animal
models
needs
be
further
elucidated
humans,
pathophysiology
γ-band
alteration
common
denominator
different
neuropsychiatric
disorders.
The
purpose
this
narrative
review
outline
framework
converging
results
conditions
characterized
abnormality,
neurochemical
brain
rhythms.
Язык: Английский
The role of Neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in MS and AQP4-NMOSD: Advancing clinical applications.
eNeurologicalSci,
Год журнала:
2025,
Номер
38, С. 100550 - 100550
Опубликована: Янв. 6, 2025
Fluid
biomarkers
such
as
Glial
Fibrillary
Acidic
Protein
(GFAP)
and
Neurofilament
Light
(NfL)
play
important
roles
in
the
diagnosis,
monitoring,
evaluation
of
therapeutic
responses
conditions
Multiple
Sclerosis
(MS)
Aquaporin-4
Neuromyelitis
Optica
Spectrum
Disorder
(AQP4-NMOSD).
These
offer
key
insights
into
underlying
pathophysiological
mechanisms
these
diseases,
enabling
effective
follow-up
personalized
treatment
approaches,
which
are
essential
for
improving
patient
outcomes.
Herein,
we
synthesize
structural
attributes,
functional
roles,
clinical
significance
GFAP
NfL
context
MS
AQP4-NMOSD.
We
explore
critical
implications
disease
manifestation
progression,
emphasizing
necessity
to
develop
standardized
methodologies
multicentric
studies
confirm
their
applicability.
Язык: Английский
Higher levels of AKT-interacting protein in the frontal pole from people with schizophrenia are limited to a sub-group who have a marked deficit in cortical muscarinic M1 receptors
Psychiatry Research,
Год журнала:
2024,
Номер
341, С. 116156 - 116156
Опубликована: Авг. 29, 2024
Язык: Английский
Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic
Physiological Research,
Год журнала:
2024,
Номер
unknown, С. S615 - S639
Опубликована: Ноя. 22, 2024
Schizophrenia,
a
severe
psychiatric,
neurodevelopmental
disorder
affecting
about
0.29-1
%
of
the
global
population,
is
characterized
by
hallucinations,
delusions,
cognitive
impairments,
disorganized
thoughts
and
speech,
leading
to
significant
social
withdrawal
emotional
blunting.
During
1980s,
considerations
diseases
that
result
from
complex
interactions
genetic
background
environmental
factors
started
appear.
One
critical
times
vulnerability
perinatal
period.
Concerning
schizophrenia,
obstetric
complications
are
associated
with
hypoxia
fetus
or
neonate
were
identified
as
risk.
Also,
maternal
infections
during
pregnancy
linked
schizophrenia
epidemiological,
serologic
studies.
Research
efforts
then
led
development
experimental
models
testing
impact
immune
activation
on
disorders.
These
usually
studied
separately,
but
given
now
validated,
it
feasible
investigate
both
together.
Inclusion
additional
factors,
such
metabolic
disturbances
chronic
stress,
may
need
be
considered
also.
Understanding
interplay
in
schizophrenia's
etiology
crucial
for
developing
targeted
prevention
therapeutic
strategies.
Язык: Английский
Are negative symptoms more common in schizophrenia patients with positive family psychiatric history?
Romanian Journal of Psychiatry & Psychotherapy,
Год журнала:
2022,
Номер
24(1), С. 5 - 10
Опубликована: Март 31, 2022
Background
and
aim.
Schizophrenia,
a
complex
mental
health
disorder
affecting
one
in
300
individuals
globally,
presents
with
clinical
manifestations
influenced
by
hereditary,
environmental
neurobiological
factors.
Despite
extensive
research,
its
etiology
pathophysiological
mechanisms
remain
incompletely
understood.
Our
aim
was
to
explore
the
impact
of
family
psychiatric
history
on
negative
symptoms
this
disorder.
Method.
We
performed
cross-sectional
study
involving
110
patients
diagnosed
schizophrenia.
Participants
were
assessed
using
Positive
Negative
Syndrome
Scale
(PANSS)
Global
Assessment
Functioning
(GAF)
score.
Logistic
regression
analyses
employed
examine
relationships
between
variables.
Results.
Patients
positive
(PFPH)
have
shown
statistically
significant
increase
PANSS
scores
compared
those
(NFPH).
While
individual
subdomains
showed
variations,
overall
symptomatology
notably
accentuated
PFPH
group.
Conclusion.
findings
contribute
understanding
schizophrenia’s
multifactorial
nature,
highlighting
role
influencing
course
disease.
Tailoring
interventions
based
needs
may
enhance
outcomes
improve
quality
life
living
Язык: Английский