Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review DOI Creative Commons
Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Sirajunisa Talath

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(1), С. 30 - 30

Опубликована: Янв. 6, 2025

Extensive investigation has been conducted on plant-based resources for their pharmacological usefulness, including various cancer types. The scope of this review is wider than several studies with a particular focus breast cancer, which an international health concern while studying sources flavonoids, carotenoids, polyphenols, saponins, phenolic compounds, terpenoids, and glycosides apart from focusing nursing. Important findings prior are synthesized to explore these compounds' sources, mechanisms action, complementary synergistic effects, associated side effects. It was reviewed that the exposure certain doses catechins, piperlongumine, lycopene, isoflavones cucurbitacinfor sufficient period can provide profound anticancer benefits through biological events such as cell cycle arrest, cells undergoing apoptosis disruption signaling pathways including, but not limited JAK-STAT3, HER2-integrin, MAPK. Besides, study also covers potential adverse effects phytochemicals. Regarding mechanisms, widest attention paid Complementary strategies discussed indicate it would be realistic alter dosage delivery systems liposomes, nanoparticles, nanoemulsions, films enhance efficacy. Future research directions include refining approaches, further elucidating molecular conducting clinical trials validate findings. These efforts could significantly advance role phytocompounds in management.

Язык: Английский

Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review DOI Creative Commons
Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Sirajunisa Talath

и другие.

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(1), С. 30 - 30

Опубликована: Янв. 6, 2025

Extensive investigation has been conducted on plant-based resources for their pharmacological usefulness, including various cancer types. The scope of this review is wider than several studies with a particular focus breast cancer, which an international health concern while studying sources flavonoids, carotenoids, polyphenols, saponins, phenolic compounds, terpenoids, and glycosides apart from focusing nursing. Important findings prior are synthesized to explore these compounds' sources, mechanisms action, complementary synergistic effects, associated side effects. It was reviewed that the exposure certain doses catechins, piperlongumine, lycopene, isoflavones cucurbitacinfor sufficient period can provide profound anticancer benefits through biological events such as cell cycle arrest, cells undergoing apoptosis disruption signaling pathways including, but not limited JAK-STAT3, HER2-integrin, MAPK. Besides, study also covers potential adverse effects phytochemicals. Regarding mechanisms, widest attention paid Complementary strategies discussed indicate it would be realistic alter dosage delivery systems liposomes, nanoparticles, nanoemulsions, films enhance efficacy. Future research directions include refining approaches, further elucidating molecular conducting clinical trials validate findings. These efforts could significantly advance role phytocompounds in management.

Язык: Английский

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