Materials Today Bio,
Год журнала:
2024,
Номер
30, С. 101385 - 101385
Опубликована: Дек. 6, 2024
M2
macrophage-derived
extracellular
vesicles
(M2-EVs)
demonstrate
the
capacity
to
reduce
pro-inflammatory
M1
macrophage
formation,
thereby
restoring
M1-M2
balance
and
promoting
immunoregulation.
However,
efficacy
of
M2-EVs
in
regulating
polarization
subsequently
enhancing
osseointegration
around
titanium
(Ti)
implants
patients
with
diabetes
mellitus
(DM)
remains
be
elucidated.
In
this
study,
Ti
were
coated
polydopamine
facilitate
adherence.
vitro
experiment
results
demonstrated
that
could
carry
miR-23a-3p,
inhibiting
NOD-like
receptor
protein3(NLRP3)
inflammasome
activation
reducing
levels
inflammatory
cytokines
such
as
IL-1β
by
targeting
NEK7.
This
improved
enhanced
mineralization
on
implant
surfaces.
The
vivo
diabetic
conditions,
nanocoated
significantly
promoted
high-quality
bone
deposition
implants.
current
provide
a
novel
perspective
for
simple
effective
decoration
implants;
clinically,
method
may
afford
osteoimmunomodulatory
effects
DM.
Pharmaceutics,
Год журнала:
2024,
Номер
16(6), С. 709 - 709
Опубликована: Май 24, 2024
Of
all
the
numerous
nanosized
extracellular
vesicles
released
by
a
cell,
endosomal-originated
exosomes
are
increasingly
recognized
as
potential
therapeutics,
owing
to
their
inherent
stability,
low
immunogenicity,
and
targeted
delivery
capabilities.
This
review
critically
evaluates
transformative
of
exosome-based
modalities
across
pharmaceutical
precision
medicine
landscapes.
Because
precise
biomolecular
cargo
delivery,
posited
ideal
candidates
in
drug
enhancing
regenerative
strategies,
advancing
diagnostic
technologies.
Despite
significant
market
growth
projections
exosome
therapy,
its
utilization
is
encumbered
substantial
scientific
regulatory
challenges.
These
include
lack
universally
accepted
protocols
for
isolation
complexities
associated
with
navigating
environment,
particularly
guidelines
set
forth
U.S.
Food
Drug
Administration
(FDA).
presents
comprehensive
overview
current
research
trajectories
aimed
at
addressing
these
impediments
discusses
prospective
advancements
that
could
substantiate
clinical
translation
exosomal
therapies.
By
providing
analysis
both
capabilities
hurdles
therapeutic
applications,
this
article
aims
inform
direct
future
paradigms,
thereby
fostering
integration
systems
into
mainstream
practice.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 366 - 366
Опубликована: Март 13, 2025
Chronic
wounds
pose
a
significant
healthcare
challenge,
impacting
millions
of
patients
worldwide
and
burdening
systems
substantially.
These
often
occur
as
comorbidities
are
prone
to
infections.
Such
infections
hinder
the
healing
process,
complicating
clinical
management
proving
recalcitrant
therapy.
The
environment
within
wound
itself
poses
challenges
such
lack
oxygen,
restricted
blood
flow,
oxidative
stress,
ongoing
inflammation,
bacterial
presence.
Traditional
systemic
treatment
for
chronic
peripheral
may
not
be
effective
due
inadequate
supply,
resulting
in
unintended
side
effects.
Furthermore,
topical
applications
impervious
persistent
biofilm
A
growing
concern
is
therapeutic
modalities
treating
wounds.
Additionally,
chemically
harsh
microenvironment
can
reduce
effectiveness
treatments,
highlighting
need
drug
delivery
that
deliver
therapies
precisely
where
needed
with
optimal
dosages.
Compared
cell-based
therapies,
exosome-based
offer
distinct
advantages
cell-free
approach
treatment.
Exosomes
endosomal
origin
enable
cell-to-cell
communications,
they
possess
benefits,
including
biocompatibility
decreased
immunogenicity,
making
them
ideal
vehicles
efficient
targeting
minimizing
off-target
damage.
However,
exosomes
rapidly
cleared
from
body,
it
difficult
maintain
concentrations
at
sites.
hydrogel-based
development
biocompatible
scaffolds
beneficial
sustained
release
prolong
presence
these
Engineered
have
been
shown
stability
promoting
compared
their
unmodified
counterparts.
Significant
progress
has
made
this
field,
but
further
research
essential
unlock
potential.
This
review
seeks
explore
benefits
opportunities
wounds,
ensuring
efficacy
precise
despite
obstacles
posed
by
environment.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Март 13, 2025
Exosomes,
nanosized
extracellular
vesicles
released
by
various
cell
types,
are
intensively
studied
for
the
diagnosis
and
treatment
of
cancer
neurodegenerative
diseases,
they
also
display
high
usability
in
regenerative
medicine.
Emphasizing
their
diagnostic
potential,
exosomes
serve
as
carriers
disease-specific
biomarkers,
enabling
non-invasive
early
detection
personalized
The
cargo
loading
with
therapeutic
agents
presents
an
innovative
strategy
targeted
drug
delivery,
minimizing
off-target
effects
optimizing
interventions.
In
medicine,
play
a
crucial
role
intercellular
communication,
facilitating
tissue
regeneration
through
transmission
bioactive
molecules.
While
acknowledging
existing
challenges
standardization
scalability,
ongoing
research
efforts
aim
to
refine
methodologies
address
regulatory
considerations.
summary,
this
review
underscores
transformative
potential
reshaping
landscape
medical
interventions,
particular
emphasis
on
cancer,
Journal of Cosmetic Dermatology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
ABSTRACT
Background
There
are
exciting
advances
in
the
field
of
exosomes
research
as
a
potential
regenerative
therapy.
Platelet‐rich
plasma
represents
an
abundant
source
exosomes.
Aim
To
present
evidence
on
use
platelet‐rich
plasma‐derived
dermatology
and
discuss
current
technical
limitations.
Methods
A
literature
search
was
conducted
using
Embase
(Ovid),
Web
Science,
ClinicalTrials.gov
June
2024.
Results
contain
myriad
growth
factors,
genetic
materials,
lipids
that
mediate
paracrine
signaling.
Several
preclinical
studies
have
demonstrated
their
wound
healing.
This
includes
faster
contraction
diabetic
animal
models,
well
enhanced
angiogenesis,
increased
cell
proliferation
migration,
protection
against
hyperglycemic
conditions
vitro.
case
study
reported
topical
platelet‐derived
exosome
product
tried
successfully
patient
with
persistent
scalp
wounds.
In
contrast,
there
is
scarce
information
hair
skin
rejuvenation.
Isolation
techniques,
activation
methods,
methods
delivery
not
been
optimized,
which
warrants
further
research.
Novel
such
hydrogel‐based
preparations,
may
enable
application
Conclusion
Exosomes
derived
from
therapeutic
potential.
More
needed
to
standardize
its
use.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(34), С. 8431 - 8443
Опубликована: Янв. 1, 2024
This
study
explores
cryogels,
loaded
with
CP
and
berberine
BB
for
wound
healing.
The
cryogels
exhibited
high
porosity,
biocompatibility,
sustained
release
of
BB.
scaffolds
accelerated
closure
improved
healing
in
a
rat
model.
