Genetics in Medicine, Год журнала: 2023, Номер 25(7), С. 100912 - 100912
Опубликована: Июль 1, 2023
Язык: Английский
Biochimica et Biophysica Acta (BBA) - General Subjects, Год журнала: 2025, Номер 1869(6), С. 130790 - 130790
Опубликована: Март 6, 2025
Язык: Английский
Процитировано
0
Genes, Год журнала: 2023, Номер 14(7), С. 1511 - 1511
Опубликована: Июль 24, 2023
The specifics of breeding and selection significantly affect genetic diversity variability within a breed. We present the data obtained from analysis 21 thoroughbred warmblood horse breeds. most detailed information is described following breeds: Arabian, Trakehner, French Trotter, Standardbred, Soviet Heavy Horse. 509,617 SNP variants in 87 stallions populations made it possible to estimate at genome-wide level distinguish studied breeds each other. In this study, we searched for heterozygous homozygous ROH regions, evaluated inbreeding using FROH analysis, generated population structure Admixture 1.3 software. Our findings indicate that Arabian breed an ancestor many study full-genome architectonics great practical importance preserving characteristics managing breeding. Studies were carried out determine regions individual search candidate genes these regions. Fifty-six influence pressure identified. research reveals consistent with directions breeds’ history origin.
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Сен. 3, 2024
Язык: Английский
Процитировано
1
Frontiers in Veterinary Science, Год журнала: 2024, Номер 11
Опубликована: Сен. 20, 2024
The reproductive performance of goats significantly influences breeding efficiency and economic returns, with litter size serving as a comprehensive indicator. Despite this, research on the genetic control remains limited. Therefore, we aimed to explore candidate genes affecting fecundity compared whole-genome sequences (WGS) 15 high-litter (HL) low-litter (LL) in Chuanzhong black goats. Then diversity genomic variation patterns were analyzed by phylogenetic, principal component population structure analysis, it was found that HL LL subpopulations diverged. Population evolutionary selection elimination analysis performed Fst θπ resulted 506 annotated 528 LL. These mainly related Hippo signaling pathway, G protein-coupled receptor activity, cell surface gonadal development. According selected regions important pathways, g.89172108T > variant locus exon AMH gene associated ( P < 0.05), which could be used an auxiliary for high fertility Goat.
Язык: Английский
Процитировано
1
Journal of Cellular Biochemistry, Год журнала: 2024, Номер 126(1)
Опубликована: Май 23, 2024
The chromodomain helicase DNA-binding (CHD) and chromobox (CBX) families of proteins play crucial roles in cell fate decisions, differentiation, proliferation a broad variety tissues types. CHD are ATP-dependent epigenetic enzymes actively engaged transcriptional regulation, DNA replication, damage repair, whereas CBX repressors mainly involved the formation heterochromatin. pleiotropic effects largely dependent on their versatility to interact with other key components machinery. Although function regulatory modes factors well established many types, little is known about during osteogenic differentiation. A single-cell RNA-sequencing analysis mouse incisor dental pulp revealed distinct spatiotemporal expression patterns CHD- CBX-encoding genes within different clusters mesenchymal stromal cells (MSCs) representing various stages Additionally, encoding interaction partners proteins, such as subunits trithorax-COMPASS polycomb chromatin remodeling complexes, exhibited differential co-expression behaviors MSC subpopulations. Thus, show partially overlapping but MSCs, suggesting decisions.
Язык: Английский
Процитировано
0
Genetics in Medicine, Год журнала: 2023, Номер 25(7), С. 100912 - 100912
Опубликована: Июль 1, 2023
Язык: Английский
Процитировано
0