An insight into the advanced synthetic recipes to access ubiquitous indole heterocycles

Tetrahedron Letters, Год журнала: 2021, Номер 85, С. 153458 - 153458

Опубликована: Окт. 18, 2021

Язык: Английский

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Recent advances in the transition metal-free oxidative dehydrogenative aromatization of cyclohexanones

Organic & Biomolecular Chemistry, Год журнала: 2021, Номер 19(29), С. 6380 - 6391

Опубликована: Янв. 1, 2021

Cyclohexanone is a simple and widely available raw material that can be obtained from lignin biomass, highlighting its renewable sustainable features. Cyclohexanone, as an important synthon in organic chemistry, has been demonstrated to viable for constructing functionalized arenes benzoheteroarenes, with recent extensive development on transition metal-free oxidative dehydrogenative aromatization. This review focuses research progress the derivation of cyclohexanones via

Язык: Английский

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Three-component selective synthesis of phenothiazines and bis-phenothiazines under metal-free conditions

Organic & Biomolecular Chemistry, Год журнала: 2023, Номер 21(9), С. 1920 - 1926

Опубликована: Янв. 1, 2023

An iodine-containing reagent promoted three-component method for the selective synthesis of phenothiazines and bis-phenothiazines has been developed. The present protocol starts from simple easily available cyclohexanones, elemental sulfur, inorganic ammonium salts, selectively producing in satisfactory yields under aerobic conditions. This advantages readily starting materials metal-free conditions, affording a facile practical approach preparation bis-phenothiazines.

Язык: Английский

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Current Advances in Transition Metal-Free Access to Indoles. A Review

Organic Preparations and Procedures International, Год журнала: 2023, Номер 55(4), С. 299 - 316

Опубликована: Янв. 23, 2023

Язык: Английский

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Iron-catalyzed indolo[2,3-c]quinoline synthesis from nitroarenes and benzylic alcohols/aldehydes promoted by elemental sulfur

Green Synthesis and Catalysis, Год журнала: 2021, Номер 3(1), С. 95 - 101

Опубликована: Ноя. 27, 2021

An iron-catalyzed strategy for the rapid synthesis of indolo[2,3-c]quinolines has been developed. This cascade reaction involving alcohol oxidation, nitro reduction, and oxidative annulation was achieved in a one-pot. The present protocol started from mono-functionalized indoles readily available benzylic alcohols/aldehydes, affording variety functionalized satisfactory yields.

Язык: Английский

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Nitrogen, Oxygen, and Sulphur Heterocycles as Potent Anti‐Inflammatory Agents: Insight Into the Synthetic Routes

ChemistrySelect, Год журнала: 2025, Номер 10(9)

Опубликована: Март 1, 2025

Abstract Nitrogen, oxygen, and sulfur‐containing heterocyclic compounds are broadly established as key scaffolds with potential chemical biological properties. Benzimidazole, indole, benzoxazole, benzothiazole, pyrazole, thiophene analogs significant motifs that bear almost all pharmacological activities. Anti‐inflammatory activity is one of the most commonly associated activities these heterocycles thus has attracted interest researchers to synthesize study them in‐depth. The present review highlights mainly various synthetic methodologies utilized prepare diverse their properties limited anti‐inflammatory Further, this will provide a comprehensive idea used biologically active nitrogen, sulfur‐bearing possibly invoke new thoughts in search for rational designs developing more promising agents.

Язык: Английский

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Metal- and Solvent-Free Synthesis of Substituted Pyrimidines via an NH₄I-Promoted Three-Component Tandem Reaction

The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(20), С. 14697 - 14707

Опубликована: Сен. 29, 2023

A facile and practical approach for the preparation of substituted pyrimidines from ketones, NH4OAc, N,N-dimethylformamide dimethyl acetal has been described. This NH4I-promoted three-component tandem reaction affords a broad range in acceptable yields under metal- solvent-free conditions. The present methodology features advantages simple easily available starting materials, conditions, substrate scope with good functional group tolerance, gram-scale synthesis.

Язык: Английский

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Iodide-Dependent Selective Dehydroaromatization Affording Maleimide-Fused 9,10-Phenanthrenes and Their Analogues

Organic Letters, Год журнала: 2023, Номер 25(39), С. 7142 - 7147

Опубликована: Сен. 21, 2023

A novel and selective synthesis of polycyclic fused maleimides from easily available raw materials under metal-free conditions is presented. This cascade protocol involves self-condensation cyclohexanones, followed by Diels-Alder reaction with maleimides, intramolecular dehydration, dehydroaromatization in a one-pot fashion, affording maleimide-fused 9,10-phenanthrenes their analogues satisfactory yields. Notably, iodide reagents play critical role switching the selectivity toward full or partial dehydrogenation compounds.

Язык: Английский

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Chemoselective synthesis of α-carboline derivatives via hypervalent iodine-catalyzed [3+3] annulation under metal-free conditions

Green Synthesis and Catalysis, Год журнала: 2023, Номер 5(2), С. 112 - 116

Опубликована: Янв. 5, 2023

A strategy for the synthesis of α-carboline derivatives from indole-3-carboxaldehydes and 3-aminocyclohex-2-enones under metal-free conditions has been developed. The combination use phenyliodine (III) diacetate (PIDA) benzoic acid could significantly facilitate corresponding [3 ​+ ​3] annulation process. This newly developed featured unextraordinary chemoselectivity, good functional group tolerance preservation carbonyl ketone substrates, which offers possibility further transformation products.

Язык: Английский

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Metal‐Free Synthesis of Benzo[a]phenanthridines from Aromatic Aldehydes, Cyclohexanones, and Aromatic Amines

Chinese Journal of Chemistry, Год журнала: 2021, Номер 40(3), С. 365 - 370

Опубликована: Ноя. 2, 2021

Comprehensive Summary A three‐component synthesis of benzo[ α ]phenanthridines from aromatic aldehydes, cyclohexanones, and amines has been developed, which is mediated by KI/DMSO/camphorsulfonic acid to afford a variety functionalized in satisfactory yields. The present strategy provides biaryl motif ortho the nitrogen atom potential be used as ligand further modification. With advantages readily available starting materials, transition‐metal‐free conditions, gram‐scale synthesis, broad substrate scope, this protocol an efficient approach for preparation diverse ]phenanthridines.

Язык: Английский

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