European Journal of Organic Chemistry,
Год журнала:
2022,
Номер
2022(46)
Опубликована: Ноя. 10, 2022
Abstract
In
the
presence
of
iodine,
synthesis
S
‐benzoazolyl
chromone
derivatives
by
one‐pot
manner
is
reported.
Thus,
2‐aminophenol
firstly
reacted
with
tetramethylthiuram
disulfide
(TMTD)
to
form
2‐mercaptobenzoxazole,
and
then
coupled
2‐hydroxyphenyl
enaminones
obtain
chromones
through
manner.
This
method
features
mild
conditions,
easy
operation,
environmentally
friendliness
wide
substrate
scopes,
illustrating
practical
application
value
in
organic
synthesis.
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(12), С. 8632 - 8640
Опубликована: Июнь 6, 2024
Herein,
we
disclosed
a
highly
efficient
pathway
toward
3-selenylated
chromone
derivatives
via
electrocatalytic
cascade
selenylation/cyclization/deamination
of
2-hydroxyaryl
enaminones
with
diselenides.
This
method
showed
mild
conditions,
easy
operation,
wide
substrate
scope,
and
good
functional
group
tolerance.
Furthermore,
this
electrosynthesis
strategy
was
amendable
to
scale-up
the
reaction.
Additionally,
preliminary
experiments
revealed
that
reaction
probably
proceeded
cation
instead
radical
pathway.
A
cost-effective
and
environmentally
friendly
method
for
the
direct
conversion
of
primary
amides
to
nitriles
was
developed
using
commercially
available
non-toxic
ethyl
bromodifluoroacetate
as
a
difluorocarbene
precursor
under
metal-free
ligand-free
conditions.
The
reaction
features
high
yields
tolerates
various
sensitive
moieties,
including
alkyl,
alkenyl,
ether,
sulfone,
sulfoxide,
heteroaryl,
chloro,
bromo,
iodo,
hydroxyl,
nitro,
cyano
groups,
late-stage
modification
complex
molecules
is
also
feasible.
Moreover,
present
effective
on
large
scales,
showing
potential
industrial
application.
European Journal of Organic Chemistry,
Год журнала:
2023,
Номер
26(46)
Опубликована: Окт. 24, 2023
Abstract
An
electrochemical
synthesis
of
various
3‐selenylated
chromones
via
selenylation
alkynyl
aryl
ketones
without
the
employment
catalyst
and
chemical‐oxidant
is
described
here.
This
method
features
mild
conditions,
high
efficiency,
wide
substrate
scope.
Furthermore,
scale‐up
reaction
runs
smoothly
which
indicates
practicability
this
electrosynthesis
strategy.
Current Organic Chemistry,
Год журнала:
2024,
Номер
28(14), С. 1079 - 1101
Опубликована: Май 6, 2024
Abstract:
Trihaloisocyanuric
acids
[1,3,5-trihalo-1,3,5-triazine-2,4,6-(1H,3H,5H)-triones]
are
commercially
available
or
easily
prepared
solids.
They
highly
reactive,
stable,
handled,
and
have
an
excellent
atom
economy,
transferring
up
to
three
halogen
atoms
organic
substrates.
In
these
regards,
the
present
review
summarizes
their
synthetic
applications
as
safe
convenient
reagents.
Therefore,
electrophilic
halogenation
reactions
of
alkenes,
alkynes,
arenes,
heteroarenes,
carbonyl
compounds,
heteroatoms,
well
radical
involving
saturated
substrates
in
situ
halogenated
intermediates
for
Appel-type
presented
discussed.
Remarkably,
trihaloisocyanuric
processes
construction
heteroarene
scaffolds
based
on
halo-
oxidative
cyclization,
multicomponent
reactions,
telescopic
also
given.
Organic Letters,
Год журнала:
2022,
Номер
24(38), С. 7026 - 7030
Опубликована: Сен. 21, 2022
Vinyl
triflates
are
commonly
employed
as
electrophilic
vinyl
sources
in
complex
synthesis.
The
triflation
of
enolates
is
required
for
the
preparation
triflates,
generally
under
strongly
basic
conditions.
Herein,
reaction
between
alkynes
and
dimethyl(methylthio)sulfonium
trifluoromethanesulfonate
presented,
which
leads
to
development
a
facile
synthesis
β-methylthio
chemo-,
regio-,
stereoselective
manner
neutral
extremely
simple
Chinese Journal of Organic Chemistry,
Год журнала:
2022,
Номер
42(10), С. 3398 - 3398
Опубликована: Янв. 1, 2022
A
practical
method
for
the
synthesis
of
various
thiocyanated
5-membered
aromatic
heterocycles
through
electrochemical
cross-coupling
(pyrazoles,
pyrroles,
furans
and
thiophenes)
with
NH4SCN
under
chemical
oxidantand
exogenous
electrolyte-free
conditions
was
developed.NH4SCN
played
dual
roles
a
supporting
electrolyte
reagent,
thus
simplify
reaction
system.
Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Май 18, 2022
The
application
of
PhICl2/NH4SCN
and
PhICl2/KSeCN
reagent
systems
to
the
synthesis
biologically
active
S/SeCN-containing
isocoumarins
via
a
process
involving
thio/selenocyanation,
enabled
by
thio/selenocyanogen
chloride
generated
in
situ,
followed
with
an
intramolecular
lactonization
was
realized.
Gram-scale
synthesis,
further
derivatization
access
C4
thio/selenocyanated
Xyridin
A
anti-tumor
activities
obtained
products
highlight
potential
use
this
method.
Abstract
A
convenient
and
environmentally
friendly
visible‐light‐promoted
annulation
reaction
of
2‐alkynylbiphenyls
with
diaryldisulfide
for
the
synthesis
9‐sulfenylphenanthrenes
bearing
a
sulfur‐containing
functional
group
has
been
developed.
This
mild
efficient
approach
was
achieved
through
continuous
irradiation
visible
light
under
metal‐free
additive‐free
conditions.
range
9‐sulfenylphenanthrene
products
were
prepared
in
moderate
to
good
yields
broad
scope
tolerance.
