Iodine Promoted Synthesis of S‐Benzoazolyl Chromones by a Three‐Component One‐Pot Reaction DOI

Xin‐Yi Jiang,

Xi Wang,

Cheng‐Li Yang

и другие.

European Journal of Organic Chemistry, Год журнала: 2022, Номер 2022(46)

Опубликована: Ноя. 10, 2022

Abstract In the presence of iodine, synthesis S ‐benzoazolyl chromone derivatives by one‐pot manner is reported. Thus, 2‐aminophenol firstly reacted with tetramethylthiuram disulfide (TMTD) to form 2‐mercaptobenzoxazole, and then coupled 2‐hydroxyphenyl enaminones obtain chromones through manner. This method features mild conditions, easy operation, environmentally friendliness wide substrate scopes, illustrating practical application value in organic synthesis.

Язык: Английский

Transition metal-free tunable synthesis of 3-(trifluoromethylthio) and 3-trifluoromethylsulfinyl chromones via domino C-H functionalization and chromone annulation of enaminones DOI
Tao Zhou, Jing Zhou, Yunyun Liu

и другие.

Chinese Chemical Letters, Год журнала: 2024, Номер 35(11), С. 109683 - 109683

Опубликована: Март 2, 2024

Язык: Английский

Процитировано

16

Electrocatalytic Cascade Selenylation/Cyclization/Deamination of 2-Hydroxyaryl Enaminones: Synthesis of 3-Selenylated Chromones under Mild Conditions DOI

Kaili Cen,

Yuan Liu,

Junhong Yu

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(12), С. 8632 - 8640

Опубликована: Июнь 6, 2024

Herein, we disclosed a highly efficient pathway toward 3-selenylated chromone derivatives via electrocatalytic cascade selenylation/cyclization/deamination of 2-hydroxyaryl enaminones with diselenides. This method showed mild conditions, easy operation, wide substrate scope, and good functional group tolerance. Furthermore, this electrosynthesis strategy was amendable to scale-up the reaction. Additionally, preliminary experiments revealed that reaction probably proceeded cation instead radical pathway.

Язык: Английский

Процитировано

6

Difluorocarbene-Enabled Dehydration of Primary Amides To Access Nitriles DOI

Bofan Feng,

Huosheng Guo,

Xiaosha Wang

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Март 16, 2025

A cost-effective and environmentally friendly method for the direct conversion of primary amides to nitriles was developed using commercially available non-toxic ethyl bromodifluoroacetate as a difluorocarbene precursor under metal-free ligand-free conditions. The reaction features high yields tolerates various sensitive moieties, including alkyl, alkenyl, ether, sulfone, sulfoxide, heteroaryl, chloro, bromo, iodo, hydroxyl, nitro, cyano groups, late-stage modification complex molecules is also feasible. Moreover, present effective on large scales, showing potential industrial application.

Язык: Английский

Процитировано

0

Formal [1 + 2 + 3] Annulation of Anilines and CF3-Containing Ynones via 6π-Electrocyclization DOI Creative Commons
Lili Feng, Shao‐Fei Ni,

Yunfei Lai

и другие.

Precision Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Июнь 5, 2025

Язык: Английский

Процитировано

0

Electrochemical Selenylation of Alkynyl Aryl Ketones: Efficient Synthesis of 3‐Selenylated Chromones under Catalyst‐ and Chemical‐Oxidant‐Free Conditions DOI

Kaili Cen,

Jiahao Wei,

Yuan Liu

и другие.

European Journal of Organic Chemistry, Год журнала: 2023, Номер 26(46)

Опубликована: Окт. 24, 2023

Abstract An electrochemical synthesis of various 3‐selenylated chromones via selenylation alkynyl aryl ketones without the employment catalyst and chemical‐oxidant is described here. This method features mild conditions, high efficiency, wide substrate scope. Furthermore, scale‐up reaction runs smoothly which indicates practicability this electrosynthesis strategy.

Язык: Английский

Процитировано

7

Trihaloisocyanuric Acids: Useful Reagents for Halogenation Reactions and Heterocyclic Scaffold Construction DOI
Marcio C. S. de Mattos

Current Organic Chemistry, Год журнала: 2024, Номер 28(14), С. 1079 - 1101

Опубликована: Май 6, 2024

Abstract: Trihaloisocyanuric acids [1,3,5-trihalo-1,3,5-triazine-2,4,6-(1H,3H,5H)-triones] are commercially available or easily prepared solids. They highly reactive, stable, handled, and have an excellent atom economy, transferring up to three halogen atoms organic substrates. In these regards, the present review summarizes their synthetic applications as safe convenient reagents. Therefore, electrophilic halogenation reactions of alkenes, alkynes, arenes, heteroarenes, carbonyl compounds, heteroatoms, well radical involving saturated substrates in situ halogenated intermediates for Appel-type presented discussed. Remarkably, trihaloisocyanuric processes construction heteroarene scaffolds based on halo- oxidative cyclization, multicomponent reactions, telescopic also given.

Язык: Английский

Процитировано

2

Regio- and Stereoselective Synthesis of β-Methylthio Vinyl Triflates DOI

Meizhong Tang,

Yongjiao Wei,

Shenlin Huang

и другие.

Organic Letters, Год журнала: 2022, Номер 24(38), С. 7026 - 7030

Опубликована: Сен. 21, 2022

Vinyl triflates are commonly employed as electrophilic vinyl sources in complex synthesis. The triflation of enolates is required for the preparation triflates, generally under strongly basic conditions. Herein, reaction between alkynes and dimethyl(methylthio)sulfonium trifluoromethanesulfonate presented, which leads to development a facile synthesis β-methylthio chemo-, regio-, stereoselective manner neutral extremely simple

Язык: Английский

Процитировано

10

Electrochemical Oxidative Cross-Dehydrogenative Coupling of Five-Membered Aromatic Heterocycles with NH4SCN DOI Open Access
Hongxia Li, Peng Chen,

Zhilin Wu

и другие.

Chinese Journal of Organic Chemistry, Год журнала: 2022, Номер 42(10), С. 3398 - 3398

Опубликована: Янв. 1, 2022

A practical method for the synthesis of various thiocyanated 5-membered aromatic heterocycles through electrochemical cross-coupling (pyrazoles, pyrroles, furans and thiophenes) with NH4SCN under chemical oxidantand exogenous electrolyte-free conditions was developed.NH4SCN played dual roles a supporting electrolyte reagent, thus simplify reaction system.

Язык: Английский

Процитировано

10

PhICl2-Mediated Regioselective and Electrophilic Oxythio/Selenocyanation of o-(1-Alkynyl)benzoates: Access to Biologically Active S/SeCN-Containing Isocoumarins DOI Creative Commons

Shanqing Tao,

Aiwen Huo,

Yan Gao

и другие.

Frontiers in Chemistry, Год журнала: 2022, Номер 10

Опубликована: Май 18, 2022

The application of PhICl2/NH4SCN and PhICl2/KSeCN reagent systems to the synthesis biologically active S/SeCN-containing isocoumarins via a process involving thio/selenocyanation, enabled by thio/selenocyanogen chloride generated in situ, followed with an intramolecular lactonization was realized. Gram-scale synthesis, further derivatization access C4 thio/selenocyanated Xyridin A anti-tumor activities obtained products highlight potential use this method.

Язык: Английский

Процитировано

8

Visible‐Light‐Promoted Intramolecular Annulation of 2‐Alkynylbiphenyl Compounds to Synthesize 9‐Sulfenylphenanthrenes Under Metal‐Free and Additive‐Free Conditions DOI
Tao Ma,

Mixue Bian,

Xinxin Lin

и другие.

ChemPhotoChem, Год журнала: 2022, Номер 6(11)

Опубликована: Июль 29, 2022

Abstract A convenient and environmentally friendly visible‐light‐promoted annulation reaction of 2‐alkynylbiphenyls with diaryldisulfide for the synthesis 9‐sulfenylphenanthrenes bearing a sulfur‐containing functional group has been developed. This mild efficient approach was achieved through continuous irradiation visible light under metal‐free additive‐free conditions. range 9‐sulfenylphenanthrene products were prepared in moderate to good yields broad scope tolerance.

Язык: Английский

Процитировано

6