RSC Advances, Год журнала: 2024, Номер 14(21), С. 14835 - 14846
Опубликована: Янв. 1, 2024
In this work, we have described the use of α-bromonitrostyrenes in synthesis a wide variety carbocyclic and heterocyclic compounds under organocatalysis, metal catalysis, base-catalysis systems as well catalyst-free reactions.
Язык: Английский
Innovative Food Science & Emerging Technologies, Год журнала: 2024, Номер 92, С. 103593 - 103593
Опубликована: Фев. 4, 2024
Язык: Английский
Процитировано
10
Asian Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Abstract Herein, we report a calcium‐catalyzed, one‐pot, four‐component reaction to synthesize diversely substituted pyrroles. This atom‐economy involves sequence of reactions that proceed via in situ formation α ‐ imino ketones, Friedel‐Crafts arylation, aza‐cyclization, and aromatization the single pot. The showed broad substrate scope with good yields. We demonstrated gram‐scale synthesis post‐synthetic modifications.
Язык: Английский
Процитировано
1
Advanced Synthesis & Catalysis, Год журнала: 2023, Номер 365(20), С. 3400 - 3412
Опубликована: Сен. 6, 2023
Abstract Recently, vinylene carbonate has been developed as a powerful synthon in transition metal‐catalyzed C−H bond activation/cyclization reactions. This review introduces recent progress the use of reactant, by analyzing and comparing reaction models involving surrogate ethynol, acetylene, acetylation reagents or other reactants, while addressing related mechanisms synthetic applications.
Язык: Английский
Процитировано
11
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(13), С. 6979 - 6987
Опубликована: Март 23, 2024
Potato virus Y (PVY) is an important plant that has spread worldwide, causing significant economic losses. To search for novel structures as potent antiviral agents, a series of chiral indole derivatives containing oxazoline moieties were designed and synthesized their anti-PVY activities evaluated. Biological activity tests demonstrated many compounds exhibited promising absolute configurations obvious distinctions in bioactivities. Notably, compound (S)-4v displayed excellent curative protective efficacy against PVY, with EC50 values 328.6 256.1 μg/mL, respectively, which superior to those commercial virucide ningnanmycin (NNM, 437.4 397.4 respectively). The preliminary mechanism was investigated determine the difference between two enantiomers 4v compounds. Molecular docking indicated stronger binding affinity coating proteins PVY (PVY-CP) (−6.5 kcal/mol) compared (R)-4v (−6.2 kcal/mol). Additionally, can increase chlorophyll content defense-related enzyme more effectively than its enantiomer. Therefore, this study provides basis development agricultural chemicals.
Язык: Английский
Процитировано
4
Pest Management Science, Год журнала: 2024, Номер 80(9), С. 4450 - 4458
Опубликована: Апрель 25, 2024
Abstract BACKGROUND Potato virus Y (PVY) is a prominent representative of plant viruses. It can inflict severe damage upon Solanaceae plants, leading to global dissemination and substantial economic losses. To discover new antiviral agents, class planar chiral thiourea molecules through the key step N ‐heterocyclic carbene‐catalyzed nitrile formation reaction was synthesized with excellent optical purities for evaluations against PVY. RESULTS The absolute configurations compounds exhibited obvious distinctions in anti‐PVY activities. Notability, compound ( S )‐ 4u remarkable curative activities PVY, half maximal effective concentration (EC 50 ) 349.3 μg mL −1 , which lower than that ningnanmycin (NNM) = 400.8 ). Additionally, EC value protective effects 146.2 superior NNM (276.4 Furthermore, mechanism‐of‐action enantiomers investigated molecular docking, defensive enzyme activity tests chlorophyll content tests. CONCLUSION Biological mechanism studies have demonstrated configuration target plays crucial role interaction PVY‐CP, enhancing defense enzymes affecting content. current study has provided significant insights into roles played by chiralities protection This paves way development novel green pesticides bearing purities. © 2024 Society Chemical Industry.
Язык: Английский
Процитировано
4
Journal of Chemical Education, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Paal–Knorr reactions are a classical method for synthesizing pyrroles, using 1,4-dicarbonyl compound and amine as reactants. It has the characteristics of green chemistry, only two molecules water lost. In this teaching learning experiment, 2,5-hexanedione 4-tert-butylaniline were used to synthesize 1-(4-(tert-butyl)phenyl)-2,5-dimethyl-1H-pyrrole without solvent catalyst. This offers several advantages, including commercially available starting materials, mild reaction conditions, solvent- catalyst-free, short time, simple convenient operation, good yield, high atom economy. The experiment allows beginners master experimental skills recrystallization, filtration, NMR, well concept chemistry. Green chemistry is important environmental protection, resource conservation, sustainable development planet. Therefore, also significant undergraduates. We introduced students encouraged them discuss protection. To assess students' understanding they asked calculate metrics evaluate sustainability process answer corresponding post-course questions. Results from survey indicated an improved operation organic enhanced knowledge
Язык: Английский
Процитировано
0
Polymers, Год журнала: 2023, Номер 15(5), С. 1148 - 1148
Опубликована: Фев. 24, 2023
Light-activated polymerization is one of the most important and powerful strategies for fabrication various types advanced polymer materials. Because many advantages, such as economy, efficiency, energy saving being environmentally friendly, etc., photopolymerization commonly used in different fields science technology. Generally, initiation reactions requires not only light but also presence a suitable photoinitiator (PI) photocurable composition. In recent years, dye-based photoinitiating systems have revolutionized conquered global market innovative PIs. Since then, numerous photoinitiators radical containing organic dyes absorbers been proposed. However, despite large number initiators designed, this topic still relevant today. The interest towards continues to gain importance, which related need new capable effectively initiating chain under mild conditions. paper we present information about photoinitiated polymerization. We describe main directions application technique areas. Attention mainly focused on review high-performance sensitizers. Moreover, our latest achievements field modern acrylates.
Язык: Английский
Процитировано
9
Organic Letters, Год журнала: 2024, Номер 26(20), С. 4183 - 4188
Опубликована: Май 14, 2024
We present a novel approach for the skeletal rearrangement of an oxazole into azepine and pyrrole through dynamic electrocyclization process, showing innovative, unconventional reaction sequence. This method enables precise control regioselectivity in competitive 6π 8π reactions, rendering final products rich functional groups that can be further developed synthesis nitrogen-containing scaffolds. is unprecedented example selective seven- five-member heterocycles via ring opening or closure.
Язык: Английский
Процитировано
3
Russian Journal of General Chemistry, Год журнала: 2024, Номер 94(3), С. 558 - 590
Опубликована: Март 1, 2024
Язык: Английский
Процитировано
3
Chemistry & Biodiversity, Год журнала: 2024, Номер 21(8)
Опубликована: Май 21, 2024
Pyrrole, with its versatile heterocyclic ring structure, serves as a valuable template for generating diverse range of lead compounds various pharmacophores. Researchers and scientists globally are intrigued by pyrrole analogs their broad pharmacological potential, prompting thorough investigations aimed at advancing human welfare. This comprehensive review delves into the activities exhibited compounds, encompassing synthesis, reactions, properties alongside derivatives. In addition to detailing characteristics derivatives within context green chemistry, also examines microwave-assisted reactions. It provides insights chemical structures, natural occurrences, potential applications across domains. Furthermore, article investigates structural alterations implications on functionality, highlighting versatility foundational elements both functional materials bioactive compounds. The emphasizes need ongoing research development in field discover new benefits.
Язык: Английский
Процитировано
3