Natural Product Reports, Год журнала: 2023, Номер 41(1), С. 59 - 84
Опубликована: Окт. 11, 2023
Covering: up to 2023Huperzine alkaloids are a group of natural products belonging the
Язык: Английский
Organic Process Research & Development, Год журнала: 2024, Номер 28(5), С. 1327 - 1354
Опубликована: Март 14, 2024
The effective handling of solids in a continuous flow process is one the biggest perceived challenges remaining for modern chemistry. This Review aims to consider some processes chemistries involving which have been successfully implemented. Learnings from design these systems, and identification common blockers, will guide generalized, strategic approach drive efficiency future batch-to-flow development challenging, heterogeneous systems. Assorted techniques managing continuous-flow synthesis be presented herein through series case studies, broken down into several key categories; solubility considerations, setup components modularity, applications ultrasonication, reactor type Grignard reactions.
Язык: Английский
Процитировано
13
Chemical Science, Год журнала: 2024, Номер 15(22), С. 8280 - 8294
Опубликована: Янв. 1, 2024
The synthesis of enantiomerically pure compounds is a pivotal subject in the field chemistry, with enantioselective catalysis currently standing as primary approach for delivering specific enantiomers. Among these strategies, Cu-catalyzed asymmetric allylic substitution (AAS) significant and irreplaceable, especially when it comes to use non-stabilized nucleophiles (pK > 25). Although AAS prochiral substrates has also been widely developed, methodologies involving racemic/meso are highly desirable, undergo dynamic processes give single enantiomer products. Inspired by pioneering work Alexakis, Feringa Gennari groups, continuously employed deracemization desymmetrization enriched In this review, we mainly focus on developments over past two decades, providing an explicit outline ligands employed, scope nucleophiles, underlying their practical applications.
Язык: Английский
Процитировано
7
Catalysts, Год журнала: 2023, Номер 13(4), С. 690 - 690
Опубликована: Март 31, 2023
In the last twenty years, application of microreactors in chemical and biochemical industrial processes has increased significantly. The use microreactor systems ensures efficient process intensification due to excellent heat mass transfer within microchannels. Monitoring concentrations microchannels is critical for a better understanding physical occurring micromixers microreactors. Therefore, there growing interest performing in-line on-line analyses and/or processes. This creates tremendous opportunities incorporation spectroscopic detection techniques into production processing lines various industries. this work, an overview current applications ultraviolet–visible, infrared, Raman spectroscopy, NMR, MALDI-TOF-MS, ESI-MS monitoring (bio)catalytic continuously operated presented. manuscript includes description advantages disadvantages analytical methods listed, with particular emphasis on chemometric used data analysis.
Язык: Английский
Процитировано
11
Journal of Flow Chemistry, Год журнала: 2024, Номер 14(1), С. 257 - 279
Опубликована: Фев. 23, 2024
Язык: Английский
Процитировано
4
Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(13), С. 6979 - 6987
Опубликована: Март 23, 2024
Potato virus Y (PVY) is an important plant that has spread worldwide, causing significant economic losses. To search for novel structures as potent antiviral agents, a series of chiral indole derivatives containing oxazoline moieties were designed and synthesized their anti-PVY activities evaluated. Biological activity tests demonstrated many compounds exhibited promising absolute configurations obvious distinctions in bioactivities. Notably, compound (S)-4v displayed excellent curative protective efficacy against PVY, with EC50 values 328.6 256.1 μg/mL, respectively, which superior to those commercial virucide ningnanmycin (NNM, 437.4 397.4 respectively). The preliminary mechanism was investigated determine the difference between two enantiomers 4v compounds. Molecular docking indicated stronger binding affinity coating proteins PVY (PVY-CP) (−6.5 kcal/mol) compared (R)-4v (−6.2 kcal/mol). Additionally, can increase chlorophyll content defense-related enzyme more effectively than its enantiomer. Therefore, this study provides basis development agricultural chemicals.
Язык: Английский
Процитировано
4
Pest Management Science, Год журнала: 2024, Номер 80(9), С. 4450 - 4458
Опубликована: Апрель 25, 2024
Abstract BACKGROUND Potato virus Y (PVY) is a prominent representative of plant viruses. It can inflict severe damage upon Solanaceae plants, leading to global dissemination and substantial economic losses. To discover new antiviral agents, class planar chiral thiourea molecules through the key step N ‐heterocyclic carbene‐catalyzed nitrile formation reaction was synthesized with excellent optical purities for evaluations against PVY. RESULTS The absolute configurations compounds exhibited obvious distinctions in anti‐PVY activities. Notability, compound ( S )‐ 4u remarkable curative activities PVY, half maximal effective concentration (EC 50 ) 349.3 μg mL −1 , which lower than that ningnanmycin (NNM) = 400.8 ). Additionally, EC value protective effects 146.2 superior NNM (276.4 Furthermore, mechanism‐of‐action enantiomers investigated molecular docking, defensive enzyme activity tests chlorophyll content tests. CONCLUSION Biological mechanism studies have demonstrated configuration target plays crucial role interaction PVY‐CP, enhancing defense enzymes affecting content. current study has provided significant insights into roles played by chiralities protection This paves way development novel green pesticides bearing purities. © 2024 Society Chemical Industry.
Язык: Английский
Процитировано
4
Natural Product Reports, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
We describe the pipeline of anticancer agents from marine cyanobacteria, highlighting critical steps discovery towards development, including identification molecular target and mechanism action, solving supply problem.
Язык: Английский
Процитировано
4
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
0
Chemical Science, Год журнала: 2023, Номер 14(16), С. 4351 - 4356
Опубликована: Янв. 1, 2023
The Cu-catalyzed AAA reactions employing challenging racemic inert cyclic allylic ethers with sterically hindered Grignard reagents have been disclosed under batch and flow conditions.
Язык: Английский
Процитировано
10
Green Synthesis and Catalysis, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0