Exploring the catalytic activity of –NHSO3H functionalized natural asphalt: a sustainable and efficient catalyst for condensation reactions in water
RSC Advances,
Год журнала:
2025,
Номер
15(12), С. 9280 - 9294
Опубликована: Янв. 1, 2025
Natural
asphalt
sulfamic
acid
(NA-NHSO
3
H)
was
synthesized
through
the
functionalization
of
natural
(NA).
The
catalytic
performance
NA-NHSO
H
evaluated
in
Knoevenagel
and
Claisen–Schmidt
condensation
reactions
under
mild
conditions.
Язык: Английский
Solvent-Free and Microwave-Assisted Synthesis Enables Formation of Imidazole and Pyrazole Derivatives Through Epoxide Ring Opening
Molecules,
Год журнала:
2025,
Номер
30(8), С. 1760 - 1760
Опубликована: Апрель 14, 2025
A
solvent-free,
microwave-assisted
approach
for
the
ring-opening
reactions
of
phenyl
glycidyl
ether
with
a
series
commercially
available
imidazoles
and
pyrazoles
is
described.
Microwave
irradiation
allows
to
proceed
rapidly.
This
straightforward
efficiently
generated
adducts
competitive
yields
compared
traditional
methods
that
use
conventional
heating
or
organic
solvents.
technique
particularly
suited
high-throughput
screening
in
drug
discovery,
offering
significant
reduction
time
resource
consumption.
Язык: Английский
Ultrasound-assisted green synthesis of functionalised xanthene derivatives: Advancing sustainable sonochemical strategies
Ultrasonics Sonochemistry,
Год журнала:
2025,
Номер
unknown, С. 107367 - 107367
Опубликована: Апрель 1, 2025
Xanthenes
are
an
important
class
of
heterocycles
in
medicinal
chemistry
due
to
their
diverse
pharmacological
properties.
These
tricyclic
aromatic
compounds,
characterised
by
a
dibenzo[b,e]pyran
core
with
oxygen
atom
at
central
position,
have
gained
significant
attention
for
extensive
applications.
Beyond
pharmaceuticals,
xanthenes
widely
used
textiles,
food
industries,
electro-optical
devices,
dyes,
and
bioimaging
agents.
Xanthene
derivatives,
particularly
9-substituted
xanthenes,
exhibit
wide
range
biological
activities,
including
antiparasitic,
antibacterial,
antileishmanial,
cytotoxic,
neuroprotective,
photophysical
effects,
making
them
valuable
drug
discovery.
The
xanthene
scaffold
is
present
various
bioactive
natural
compounds
such
as
mulgravanols
A
B,
hermannol,
(+)-myrtucommulone
D,
homapanicones
blumeaxanthene
II,
acrotrione.
Clinically
relevant
xanthene-based
drugs
include
propantheline
bromide
(antimuscarinic),
methantheline
(antispasmodic),
phloxine
B
(photosensitiser
antimicrobial
therapy).
Thus,
synthetic
approaches
been
developed
the
construction
ultrasound-assisted
green
methodologies
gaining
prominence.
Ultrasound
technique
offers
advantages
over
conventional
methods,
higher
yields,
faster
reaction
rates,
improved
selectivity
under
milder
conditions.
This
review
comprehensively
explores
synthesis
functionalised
derivatives
eco-friendly
alternative.
To
best
our
knowledge,
this
first
in-depth
focusing
on
methodology
ultrasound
irradiation.
Язык: Английский
Metal-Free C(sp3)–S Bond Cleavage of Thioethers to Selectively Access Aryl Aldehydes and Dithioacetals
Chemistry,
Год журнала:
2025,
Номер
7(3), С. 89 - 89
Опубликована: Май 29, 2025
Metal-free
C(sp3)–S
bond
cleavage
of
thioethers
was
achieved
using
NCS
as
a
critical
additive.
A
wide
range
arylmethyl
were
successfully
transformed
into
aryl
aldehydes
with
satisfactory
yields
in
chloroform.
Meanwhile,
employing
fluorobenzene
the
solvent
enables
selective
formation
dithioacetals
from
thioethers,
achieving
moderate
to
good
yields.
Notably,
first
prepared
through
metal-free
and
subsequent
thioacetalization
process.
Furthermore,
these
simple
efficient
approaches
also
provide
complementary
strategies
for
accessing
important
dithioacetals.
Язык: Английский
Solvent-Free 1,3-Dipolar Cycloadditions of Nitrones for a More Sustainable Synthesis of Glycomimetics
Reactions,
Год журнала:
2025,
Номер
6(2), С. 36 - 36
Опубликована: Июнь 5, 2025
1,3-Dipolar
cycloadditions
on
nitrone
dipoles
are
key
reactions
to
access
five-membered
heterocycles,
which
useful
intermediates
in
the
synthesis
of
biologically
relevant
glycomimetics.
The
good
atomic
balance
and
high
stereoselectivity
characteristic
such
make
them
candidates
for
development
green
protocols.
In
present
work,
these
features
were
maximized
by
avoiding
use
organic
solvents
considering
starting
materials
derived
from
biomass.
Reactions
involving
(acyclic
cyclic)
carbohydrate-derived
nitrones
as
levoglucosenone
dipolarophile
considered.
Performing
selected
1,3-dipolar
neat
conditions
showed
reduced
reaction
times,
maintaining
similar
selectivity
yields
with
respect
classical
microwave
irradiation
orbital
shaking
also
exploited
increase
sustainability
synthetic
collected
results
highlight
potential
solvent-free
design
efficient
routes
according
chemistry
principles,
prevention,
atom
economy,
safer
auxiliaries,
renewable
feedstocks.
Язык: Английский