Biomarker Isolation and Characterization by Recent Spectroscopic Techniques

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 255 - 294

Опубликована: Фев. 14, 2025

Biomarkers, defined as biological molecules that serve indicators of physiological or pathological states, are indispensable in diagnosing, prognosis, and monitoring therapeutic interventions various diseases. The effective isolation precise characterization biomarkers crucial for elucidating disease mechanisms advancing personalized medicine approaches. Recent advancements spectroscopic methodologies have markedly improved biomarker detection analysis's sensitivity, specificity, resolution. This chapter examines the most current techniques, including Fourier-transform infrared (FTIR) spectroscopy, Raman nuclear magnetic resonance (NMR) liquid chromatography-mass spectrometry (LC-MS), surface-enhanced scattering (SERS), emphasizing their application characterization. These techniques provide non-destructive, high-throughput, molecular-level insights, facilitating biomarkers' identification, structural elucidation, quantification.

Язык: Английский

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General Introduction of Spectroscopy and Its Advancements for Environment Sustainability

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 1 - 26

Опубликована: Фев. 14, 2025

Spectroscopy, the study of interaction between matter and electromagnetic radiation, has become a fundamental tool in scientific analysis across various disciplines. Its applications environmental science are particularly transformative, providing critical insights into composition, structure, dynamics media. This chapter introduces principles spectroscopy discusses common techniques, including UV, infrared (IR), nuclear magnetic resonance (NMR) Additionally, it explores recent advancements spectroscopic technology methodologies that enhance sustainability. These include portable remote sensing instruments, high-resolution for pollutant detection, integration artificial intelligence data analysis. The adoption monitoring air water quality, assessing soil health, tracking greenhouse gas emissions demonstrates its pivotal role protection.

Язык: Английский

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Sustainability Challenges in Spectroscopy for Drug Discovery

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 401 - 428

Опубликована: Фев. 14, 2025

Sustainability, as defined by the Brundtland Commission, emphasizes development that meets present needs without compromising future generations. Spectroscopy plays a critical role in drug discovery characterizing molecular structures, interactions, and dynamics. However, its sustainability is challenged high energy consumption, resource-intensive manufacturing, hazardous waste disposal, reliance on rare earth elements. To address these concerns, collaborative efforts are needed to develop greener technologies, improve efficiency, promote recycling. Advancements spectroscopic techniques, such ssNMR, LC-UV HRMS, have enhanced efficiency sustainability. Innovations like tandem mass spectrometry, SERS, AI-enabled systems, attenuated total reflectance (ATR) infrared spectroscopy further accuracy while reducing environmental impact. Techniques HPLC, HPTLC, AAS, XRD etc. continue advance fields pharmaceutical analysis, contributing research development.

Язык: Английский

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Application of Raman Spectroscopy in Drug Discovery

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 221 - 254

Опубликована: Фев. 14, 2025

Raman spectroscopy, a powerful vibrational spectroscopy technique, has emerged as pivotal tool in drug discovery and development. Based on the inelastic scattering of monochromatic light, this technique allows for detailed molecular characterization with minimal sample preparation non-destructive analysis. This analytical method provides information about composition, structure, interactions pharmaceutical compounds, facilitating various stages development from initial screening to final quality control. Recent advancements instrumentation, such Surface-Enhanced (SERS) Coherent Anti-Stokes (CARS), have further expanded its applications. Its ability provide insights, coupled technology, positions an indispensable industry, that holds promise accelerating new therapeutics improving efficiency processes.

Язык: Английский

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Recent Uses of FT-IR, Raman, and Near Infrared Spectroscopy (NIRS) in Drug Discovery

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 133 - 150

Опубликована: Фев. 14, 2025

Recent advancements in drug discovery have significantly leveraged the capabilities of Fourier Transform Infrared (FT-IR), Raman, and Near Spectroscopy (NIRS) to enhance characterization optimization pharmaceutical compounds. FT-IR spectroscopy is utilized for identifying functional groups assessing molecular interactions, proving essential analysis active ingredients their formulations. Raman offers unique fingerprints, enabling polymorphs real-time monitoring release profiles, thus facilitating more informed development processes. Meanwhile, NIRS provides rapid, non-destructive complex mixtures, quality control prediction bioavailability The integration these spectroscopic techniques into high-throughput screening workflows has accelerated lead identification while improving understanding pharmacokinetics mechanisms.

Язык: Английский

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Near-Infrared Spectroscopy for Nutrient Analysis in Manure

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 295 - 328

Опубликована: Фев. 14, 2025

Organic sources of nutrients provides nutrition to the crops in balanced amount. To properly manage manuring soil, knowledge nutrient profiling is essential. Underapplication manure can reduce crop quality and yield while overapplication cause environmental deterioration. Near-Infrared spectroscopy (NIRS) has emerged as a potential rapid technique that be utilized examine mineral contents, including carbon, nitrogen, ammonia, phosphorus potassium various types manures. This analysis then used generate insight on composition applied adjust quantity required. In contrast conventional laboratory method manure, NIRS offers rapid, real-time, on-site more efficient for optimizing application practices enhancing soil fertility minimising product wastage. NIR radiation waves have wavelength ranging from 700 nm - 2500 works principle Beer- Lambert law.

Язык: Английский

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Recent Advancement of NMR in Drug Discovery Systems

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 151 - 170

Опубликована: Фев. 14, 2025

Metabolomic analysis presents a major challenge in achieving unambiguous characterization of metabolites detected samples. Among the various techniques used metabolomics, Nuclear Magnetic Resonance (NMR) spectroscopy stands out for its ability to provide detailed structural information. When integrated with other spectroscopic data, this information facilitates elucidation complex NMR spectroscopy, which is highly sophisticated and powerful tool pharmaceutical research, playing crucial part drug discovery. The advent heteronuclear has particularly revolutionized field discovery development. This chapter addresses practical aspects acquiring standard one-dimensional (1D) spectra introduces methods distinguishing known undescribed molecules rapidly. Furthermore, it delves into two-dimensional (2D) sequences, such as 1H-13C, illustrates how these combined can be determine structures natural products.

Язык: Английский

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Advanced Uses of Spectroscopic Techniques in Medical Science

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 51 - 64

Опубликована: Фев. 14, 2025

Spectroscopic techniques have transformed medical science by providing non-invasive methods for diagnosis, treatment monitoring, and research. These tools analyze how light interacts with biological tissues to reveal detailed information about their composition structure. Three key techniques—Raman spectroscopy, Near-infrared spectroscopyand magnetic resonance spectroscopy major clinical applications.Raman detects molecular changes in tissues, making it useful early cancer detection. NIRS is commonly used brain imaging monitor cerebral oxygenation, aiding the management of conditions like traumatic injury. MRS enhances measuring biochemical tissues,monitor neurological treatments.Recent advancements, including use artificial intelligence, are increasing accuracy these techniques. The ongoing development spectroscopic promises earlier detection, more precise diagnostics, tailored treatments, ultimately improving patient outcomes.

Язык: Английский

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Role of Spectroscopy in Traditional System of Medicine

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 27 - 50

Опубликована: Фев. 14, 2025

Biomedicines are growing more important as therapeutic agents in present era of modern biotechnology. Spectroscopic techniques have been a crucial part biomedical research industries. The advantages spectroscopic analysis being rapid, economical and free chemical waste compared to traditional analytical methods. Therefore, finding increasing applications the field biomedicine. In this way technique become relevant from diagnosis prevention/remediation disease. Analytical used study flavonoid components for biomedicine identification herbal advancement novel disease management. evolution natural products has always an area significant interest researchers. abundant pharmacological activities flavonoids exhibit their sufficient potential future development application

Язык: Английский

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Role of Spectroscopy in Drug Development of Allopathic Drugs

Advances in chemical and materials engineering book series, Год журнала: 2025, Номер unknown, С. 65 - 96

Опубликована: Фев. 14, 2025

Spectroscopy plays a key role in the drug development process of allopathic medicines. It provides essential tools for identification, characterization, and quantification pharmaceutical drugs. Various spectroscopic techniques, including UV-Vis, IR, NMR, mass spectrometry, enable detailed analysis molecular structure, functional groups, chemical environment candidates. assists understanding electronic, vibrational rotational transitions; concentration group determination; identification framework, dynamics, stereochemistry. These techniques collectively contribute to ensuring purity, stability, potency agents, supporting quality control regulatory compliance. aids optimization synthetic pathways formulation development, enhancing efficacy safety profiles Thus, it is indispensable advancing analytical validation, accelerating journey from discovery clinical application.

Язык: Английский

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