Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease
Nature Cardiovascular Research,
Год журнала:
2024,
Номер
3(6), С. 754 - 769
Опубликована: Июнь 17, 2024
Язык: Английский
The brain–heart axis: integrative cooperation of neural, mechanical and biochemical pathways
Nature Reviews Cardiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Язык: Английский
Altered brain functional connectivity in paroxysmal atrial fibrillation: Insights from resting-state fMRI
Journal of Radiation Research and Applied Sciences,
Год журнала:
2025,
Номер
18(3), С. 101603 - 101603
Опубликована: Май 10, 2025
Язык: Английский
Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular disease
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 1, 2023
Major
depressive
disorder
(MDD)
and
cardiovascular
disease
(CVD)
are
often
comorbid,
resulting
in
excess
morbidity
mortality.
Using
genomic
data,
this
study
elucidates
biological
mechanisms,
key
risk
factors,
causal
pathways
underlying
their
comorbidity.
We
show
that
CVDs
share
a
large
proportion
of
genetic
factors
with
MDD.
Multivariate
genome-wide
association
analysis
the
shared
liability
between
MDD
atherosclerotic
CVD
(ASCVD)
revealed
seven
novel
loci
distinct
patterns
tissue
brain
cell-type
enrichments,
suggesting
role
for
thalamus.
Part
overlap
was
explained
by
inflammatory,
metabolic,
psychosocial/lifestyle
factors.
Finally,
we
found
support
effects
to
on
risk,
but
not
from
most
MDD,
demonstrated
were
partly
metabolic
The
signature
MDD-ASCVD
comorbidity
aligns
idea
an
immunometabolic
sub-type
more
strongly
associated
than
overall
In
summary,
identify
plausible
mechanisms
MDD-CVD
comorbidity,
as
well
modifiable
prevention
individuals
Язык: Английский
Altered resting-state and dynamic functional connectivity of hypothalamic in first-episode depression: a functional magnetic resonance imaging study
Psychiatry Research Neuroimaging,
Год журнала:
2024,
Номер
345, С. 111906 - 111906
Опубликована: Сен. 23, 2024
Язык: Английский
Effect of cardiovascular diseases on brain functional changes and cognition: a systematic review of fMRI studies
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 22, 2024
Abstract
Background
Functional
magnetic
resonance
imaging
(fMRI)
is
a
useful
tool
to
evaluate
brain
inefficiencies
secondary
cardiovascular
diseases
(CVDs);
nevertheless,
limited
fMRI
studies
have
been
conducted
investigate
the
effect
of
CVD
on
functional
changes
and
cognition.
This
systematic
review
aims
explore,
synthesise,
report
outcomes
cognitive
in
patients
with
CVDs.
Methods
Two
reviewers
independently
searched
published
literature
until
August
2023
ScienceDirect,
PubMed,
Web
Science,
ClinicalTrials.gov.
A
total
22
eligible
were
considered
for
full-text
screening,
which
9
included
this
review.
The
methodological
quality
was
assessed
by
mixed
methods
appraisal
reported
as
empirically
fair.
Results
Among
312
subjects,
aged
between
49.90
±
6.10
72.20
5.70
years,
majority
had
coronary
heart
(n
=
153,
40.04%)
hypertension
188,
60.26%),
approximately
half
them
females
157,
50.32%).
Based
qualitative
synthesis,
subjects
increased
decline
poorer
task
performance
(reduced
Mini-Mental
State
Examination/Montreal
Cognitive
Assessment,
lower
mean
2-back
scores,
slower
reaction
time).
also
indicate
impaired
activity
at
supplementary
motor
area
associated
poor
ejection
fraction,
reduced
default
mode
network
suppression
linked
high
low-density
lipoprotein
cholesterol;
regional
homogeneity
amplitude
low-frequency
fluctuation
values;
connectivity.
Conclusion
It
can
be
extrapolated
that
CVDs
tend
alter
connectivity
result
impairment.
However,
future
studies,
more
stringent
homogenous
demographic
data
are
highly
recommended.
Язык: Английский
Brain functional alteration and cognitive performance in cardiovascular diseases: a systematic review of fMRI studies
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 15, 2024
Background
Functional
magnetic
resonance
imaging
(fMRI)
is
a
useful
tool
to
evaluate
brain
inefficiencies
secondary
cardiovascular
diseases
(CVDs);
nevertheless,
limited
fMRI
studies
have
been
conducted
investigate
the
effect
of
CVDs
on
functional
changes
and
cognitive
function.
This
systematic
review
aims
explore,
synthesise,
report
outcomes
(resting
state
task-based)
performance
in
patients
with
CVDs.
Methods
Two
reviewers
independently
searched
published
literature
until
April
2024
ScienceDirect,
PubMed,
Web
Science,
ClinicalTrials.gov
adhering
PRISMA
protocol.
A
total
26
eligible
were
considered
for
full-text
screening,
which
10
included
this
review.
The
methodological
quality
was
assessed
by
mixed
methods
appraisal
reported
as
empirically
fair.
Results
Among
336
subjects
CVDs,
aged
between
49.90
±
6.10
72.20
5.70
years,
majority
had
coronary
artery
(n
=
177,
52.68%)
hypertension
200,
59.52%),
approximately
half
them
females
169,
50.30%).
Based
qualitative
synthesis,
demonstrated
an
increased
decline
(reduced
Mini-Mental
State
Examination/Montreal
Cognitive
Assessment
mean
values)
attenuated
task
(lower
2-back
scores
slower
reaction
time).
also
indicated
impaired
activity
at
supplementary
motor
area
associated
poor
ejection
fraction;
reduced
default
mode
network
suppression
linked
high
low-density
lipoprotein
cholesterol;
lower
regional
homogeneity
amplitude
low-frequency
fluctuation
values;
connectivity.
In
summary,
alterations
networks
connectivity
may
contributed
diseases.
Conclusion
It
can
be
extrapolated
that
tend
alter
result
impairment
poorer
performance.
However,
future
studies,
more
stringent
homogenous
demographic
data
are
highly
recommended.
Язык: Английский