Nature Biomedical Engineering, Год журнала: 2024, Номер unknown
Опубликована: Окт. 17, 2024
Язык: Английский
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
The broad spectrum of health conditions and the global pandemic, leading to inadequate medical oxygen supply management, has driven interest in developing porous nanocarriers for effective oxygenation strategies. We aim develop an injectable carrier with regard biocompatibility, safety, prehospital availability, universal applicability. In this study, we have tried identify important functional sites on metal–organic frameworks (MOFs) gas binding help Grand canonical Monte Carlo simulation. synthesized a copper-based MOF (Cu-BTC) 1,3,5-benzenetricarboxylic acid linker through solvothermal approach as competent adsorbent storage delivery. To optimize process variables, performed statistical analysis using response surface methodology. A quadratic model was developed study interaction between independent variables (i.e., maximizing area), whose adequacy is validated by correlation experimental predicted values ANOVA method. Cu-BTC, before after loading, characterized X-ray diffraction, area, along pore distribution measurement, particle size analysis, scanning electron microscopy, transmission adsorption studies. Cu-BTC exhibited uptake 4.6 mmol g–1, highest among all carriers reported literature under same operating conditions. Overall, our findings suggest that high area (1389 m2 g–1), porosity, optimum uptake, good biocompatibility would show potential toward efficient delivery (direct targeted site) raise blood saturation level.
Язык: Английский
Процитировано
0
Meditsinskiy sovet = Medical Council, Год журнала: 2025, Номер unknown
Опубликована: Май 13, 2025
Introduction. The coronavirus epidemic, which began in 2019 and quickly spread throughout the world, was characterized by viral pneumonia acute hypoxemic respiratory failure. Aim. To evaluate effectiveness of non-invasive ventilation patients with failure due to infection at pre-intensive care unit stage. Materials methods. A retrospective cohort study included confirmed Demographic, clinical, laboratory data were collected admission, while parameters recorded both before initiation noninvasive during first 24 hours its application. Results. For most patients, successful, but some required transfer intensive ineffectiveness. Overall mortality group significant. Patients for whom ineffective older had higher rates levels certain biochemical markers upon admission. А few after ventilation, these demonstrated minute ventilatory ratio values. Factors identified as potential predictors low oxygen saturation elevated ratio, increased tidal volume several intervention began. Conclusion. Thus, can be an effective treatment caused
Язык: Английский
Процитировано
0
Medical Hypotheses, Год журнала: 2024, Номер unknown, С. 111489 - 111489
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
2
Nanomedicine, Год журнала: 2024, Номер 19(24), С. 2027 - 2043
Опубликована: Авг. 7, 2024
The post COVID-19 pandemic era has emerged with more efficient vaccines, all based on genetic materials. However, to expand the use of nucleic components as a new generation nanosystems particularly constructed increase RNA/DNA stability, half-life and facilitate administration are still required. This review highlights novel developments in mRNA pDNA vaccines formulated into nanostructures exclusively composed by biopolymeric Recent advances suggest that may arise adapting structural features biopolymers effectiveness acids. advantages offered biopolymers, such increased stability targeting ability cause revolution immunization field for offering promptly adaptable effective formulations worldwide distribution.
Язык: Английский
Процитировано
1
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(23), С. 16750 - 16750
Опубликована: Ноя. 25, 2023
Although the World Health Organization has declared end of COVID-19 pandemic, doctors continue to register new cases disease among both adults and children. Unfortunately, course in children can have a severe form, with death being potential outcome. The absence published works discussing pathological morphology prevents objective analysis disease's pathogenesis, including adult population. In this vein, our study is identify morphological features lungs' involvement evaluate virus-host interactions case patients at pediatric medical practice. We present results lungs three who died due COVID-19, highlighting predominant their respiratory organs different stages (5, 21, 50 days). This article presents data obtained from histopathological immunohistochemical investigations, taking into account clinical laboratory indicators intravital postmortem SARS-CoV-2 PCR investigations. common finding all examined endothelium microcirculation vessels, which are considered be primary target various pathogenic influencing factors. also discuss significance apoptosis as result most likely cause cell destruction. could useful for development endothelium-protective therapy prevent progression disseminated intravascular coagulation syndrome.
Язык: Английский
Процитировано
1
Nature Biomedical Engineering, Год журнала: 2024, Номер unknown
Опубликована: Окт. 17, 2024
Язык: Английский
Процитировано
0