Critical Reviews in Therapeutic Drug Carrier Systems,
Год журнала:
2024,
Номер
42(1), С. 1 - 54
Опубликована: Сен. 26, 2024
Phytopharmaceuticals
are
the
newly
termed
herbal
medicine,
which
includes
standardized
extract,
bioactive
fraction,
and
phytoconstituent.
They
have
been
practiced
to
cure,
treat,
mitigate
diseases.
many
health
benefits,
but
their
therapeutic
efficacy
is
limited
due
poor
absorption,
low
bioavailability,
early
elimination
profile.
A
novel
phospholipid
complex
a
introduced
patented
technology
developed
incorporate
plant
extracts/fractions
or
water-soluble
phytoconstituents
into
phospholipids
produce
lipid
compatible
molecular
complex,
called
phytosome,
improves
absorption
bioavailability.
In
formulations,
phytosome
most
advanced
dosage
form
that
has
an
upgraded
rate
enhanced
pharmacokinetics
compared
with
conventional
products.
The
results
from
hydrogen
bonding
between
phytoconstituents,
offering
maximum
incorporation
of
active
ingredients
lipidic
layer
core.
increased
formation
amphiphilic
phospholipid-complex
medicine.
This
review
highlights
role
on
delivery
bioactives
natural
extracts
particular
emphasis
phytosomes.
Moreover,
status
bioavailabilities,
commercial
products,
patents,
clinical
trials
phytosomal
systems
phytopharmaceuticals
were
addressed.
Abstract
Lignans
derived
from
Schisandra
chinensis
have
attracted
significant
attention
for
their
diverse
pharmacological
activities
and
clinical
potential.
This
review
presents
a
comprehensive
analysis
of
the
properties
lignans,
including
antioxidant,
anti-inflammatory,
neuroprotective,
hepatoprotective,
antibacterial/viral,
antidiabetic
anticancer
effects.
Their
multifaceted
mechanisms
action
hold
promise
therapeutic
areas
such
as
cancer,
neurodegenerative
diseases
metabolic
disorders,
aligning
with
urgent
needs.
Additionally,
this
explores
pharmacokinetics
these
bioactive
compounds,
highlighting
challenges
in
absorption,
distribution,
metabolism
excretion,
which
impact
bioavailability.
Recent
advancements
drug
delivery
systems
are
discussed,
potential
to
enhance
efficacy
settings.
Furthermore,
synergistic
effects
combining
lignans
other
agents
considered
strategy
increase
efficacy.
Future
research
is
imperative
identify
additional
active
components
elucidate
novel
action,
paving
way
expanded
applications
unlocking
full
disease
prevention
treatment.
World Journal of Gastroenterology,
Год журнала:
2025,
Номер
31(18)
Опубликована: Май 13, 2025
BACKGROUND
The
rising
global
burden
of
liver
diseases,
such
as
non-alcoholic
fatty
disease
and
fibrosis,
has
necessitated
innovative
therapeutic
approaches.
Plant-based
therapies,
recognized
for
their
anti-inflammatory
antioxidant
properties,
have
shown
promising
effects.
However,
poor
bioavailability
limits
clinical
application.
AIM
To
map
research
trends,
key
contributors,
emerging
themes
in
plant-based
therapies
combined
with
advanced
drug
delivery
systems
health.
METHODS
Using
the
Scopus
database,
645
documents
were
retrieved
analyzed
using
bibliometric
tools
Biblioshiny
VOSviewer.
Analysis
focused
on
publication
geographical
contributions,
advancements
technologies,
including
nanoparticles,
liposomes,
polymeric
micelles.
Metrics
growth
rate,
authorship
collaboration,
thematic
clustering
assessed.
RESULTS
dataset
spans
43
years
(1981-2024),
an
annual
rate
11.09%
number
publications.
Research
output
is
dominated
by
China
(33%),
followed
United
States
(24%)
India
(18%).
Collaborative
studies
accounted
24.34%
publications,
average
5.81
co-authors
per
document.
Key
innovations
include
nanoparticle
encapsulation
curcumin
silymarin,
improving
up
to
85%.
Highly
cited
demonstrated
antioxidant,
anti-inflammatory,
anti-fibrotic
properties
these
compounds.
For
instance,
nanoparticles
showed
a
70%
improvement
solubility,
silymarin
liposomal
formulations
enhanced
efficiency
62%.
Thematic
analysis
revealed
transition
from
basic
observations
molecular
pharmacokinetic
research,
focus
oxidative
stress
mitigation
hepatoprotection.
CONCLUSION
This
study
highlights
growing
synergy
between
systems,
significant
contributions
Asian
Western
countries.
Future
efforts
should
prioritize
trials,
standardization
plant
extract
formulations,
interdisciplinary
approaches
maximize
outcomes.
findings
provide
foundation
integrating
plant-derived
compounds
into
evidence-based
hepatological
addressing
critical
challenges
safety.
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2023,
Номер
unknown, С. 22 - 85
Опубликована: Ноя. 3, 2023
This
chapter
provides
a
comprehensive
review
of
recent
advances
in
nanomaterials
for
drug
delivery,
focusing
on
the
design
and
preparation
nanocarriers.
It
also
dissects
intricate
mechanisms
underpinning
loading
release,
delves
into
strategic
planning
inherent
achieving
target
delivery.
further
outlines
potential
applications
these
treating
various
diseases,
including
cancer,
infectious
neurological
disorders.
A
distinct
case
study
is
incorporated
chapter,
elucidating
promising
utility
electrospun
nanofibers
delivery
paradigms.
In
its
concluding
remarks,
engages
thoughtful
discourse
about
persistent
challenges
within
this
rapidly
evolving
field.
forecasts
trajectories
future
exploration
innovation
captivating
domain
Critical Reviews in Therapeutic Drug Carrier Systems,
Год журнала:
2024,
Номер
42(1), С. 1 - 54
Опубликована: Сен. 26, 2024
Phytopharmaceuticals
are
the
newly
termed
herbal
medicine,
which
includes
standardized
extract,
bioactive
fraction,
and
phytoconstituent.
They
have
been
practiced
to
cure,
treat,
mitigate
diseases.
many
health
benefits,
but
their
therapeutic
efficacy
is
limited
due
poor
absorption,
low
bioavailability,
early
elimination
profile.
A
novel
phospholipid
complex
a
introduced
patented
technology
developed
incorporate
plant
extracts/fractions
or
water-soluble
phytoconstituents
into
phospholipids
produce
lipid
compatible
molecular
complex,
called
phytosome,
improves
absorption
bioavailability.
In
formulations,
phytosome
most
advanced
dosage
form
that
has
an
upgraded
rate
enhanced
pharmacokinetics
compared
with
conventional
products.
The
results
from
hydrogen
bonding
between
phytoconstituents,
offering
maximum
incorporation
of
active
ingredients
lipidic
layer
core.
increased
formation
amphiphilic
phospholipid-complex
medicine.
This
review
highlights
role
on
delivery
bioactives
natural
extracts
particular
emphasis
phytosomes.
Moreover,
status
bioavailabilities,
commercial
products,
patents,
clinical
trials
phytosomal
systems
phytopharmaceuticals
were
addressed.
