Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation
Archives of Pharmacal Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Язык: Английский
Wound healing: insights into autoimmunity, ageing, and cancer ecosystems through inflammation and IL-6 modulation
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 29, 2024
Wound
healing
represents
a
complex
and
evolutionarily
conserved
process
across
vertebrates,
encompassing
series
of
life-rescuing
events.
The
runs
in
three
main
phases:
inflammation,
proliferation,
maturation/remodelling.
While
acute
inflammation
is
indispensable
for
cleansing
the
wound,
removing
infection,
eliminating
dead
tissue
characterised
by
prevalence
neutrophils,
proliferation
phase
transition
into
inflammatory
cell
profile,
shifting
towards
macrophages.
involves
development
granulation
tissue,
comprising
fibroblasts,
activated
myofibroblasts,
endothelial
cells.
Communication
among
these
cellular
components
occurs
through
intercellular
contacts,
extracellular
matrix
secretion,
as
well
paracrine
production
bioactive
factors
proteolytic
enzymes.
intricately
regulated
particularly
interleukin-6.
Prolonged
results
dysregulations
during
formation
may
lead
to
chronic
wounds
or
hypertrophic/keloid
scars.
Notably,
pathological
processes
such
autoimmune
organ
fibrosis,
tumour
microenvironment,
impaired
repair
following
viral
infections
notably
share
morphological
functional
similarities
with
tissue.
Consequently,
wound
emerges
prototype
understanding
diverse
processes.
prospect
gaining
comprehensive
holds
potential
furnish
fundamental
insights
modulation
intricate
dialogue
between
cancer
cells
non-cancer
within
ecosystem.
This
knowledge
pave
way
innovative
approaches
diagnostics,
disease
monitoring,
anticancer
therapy.
Язык: Английский
Autocrine and paracrine LIF signals to collaborate Sorafenib-resistance in Hepatocellular Carcinoma and effects of Kanglaite Injection
Phytomedicine,
Год журнала:
2024,
Номер
136, С. 156262 - 156262
Опубликована: Ноя. 15, 2024
Язык: Английский
Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 10479 - 10494
Опубликована: Дек. 1, 2024
Introduction:
Tumor-associated
macrophages
(TAMs)
play
a
crucial
role
in
the
tumor
microenvironment
(TME),
and
their
polarization
state
significantly
influences
patient
outcomes.
This
study
investigates
inhibitory
effects
of
β-glucan
extracted
from
Candida
albicans
on
lung
cancer
progression,
focusing
its
impact
TAM
induction
ferroptosis,
form
regulated
cell
death.
Methods:
Utilizing
both
vivo
animal
models
vitro
cellular
assays,
we
assessed
growth,
proliferation,
migration.
We
evaluated
by
analyzing
expression
M1
M2
markers
identified
differentially
expressed
genes
(DEGs)
related
to
ferroptosis.
The
ferroptosis
was
further
confirmed
assessing
protein
levels
ACSL4
GPX4,
intracellular
ferrous
ion
levels,
lipid
peroxides.
Results:
treatment
reduced
size
weight,
along
with
proliferation
migration,
suggesting
potent
suppressive
effect
growth.
promoted
an
M1-like
phenotype
TAMs,
as
evidenced
increased
CD86
decreased
CD206
expression,
modulated
cytokine
mRNA
levels.
RNA
sequencing
analysis
post
substantial
number
DEGs
enriched
pathway.
through
significant
upregulation
downregulation
alongside
inhibitor
Fer-1
abrogated
these
effects,
highlighting
specificity
β-glucan-mediated
polarization.
Conclusion:
These
results
collectively
provide
novel
insights
into
immunotherapeutic
potential
modulating
offering
promising
avenue
for
strategies.
Keywords:
β-glucan,
cancer,
macrophage
polarization,
C.
Язык: Английский