Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer DOI Creative Commons
Xiang He,

Ran Qin,

Xiaolan Li

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 10479 - 10494

Опубликована: Дек. 1, 2024

Introduction: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment (TME), and their polarization state significantly influences patient outcomes. This study investigates inhibitory effects of β-glucan extracted from Candida albicans on lung cancer progression, focusing its impact TAM induction ferroptosis, form regulated cell death. Methods: Utilizing both vivo animal models vitro cellular assays, we assessed growth, proliferation, migration. We evaluated by analyzing expression M1 M2 markers identified differentially expressed genes (DEGs) related to ferroptosis. The ferroptosis was further confirmed assessing protein levels ACSL4 GPX4, intracellular ferrous ion levels, lipid peroxides. Results: treatment reduced size weight, along with proliferation migration, suggesting potent suppressive effect growth. promoted an M1-like phenotype TAMs, as evidenced increased CD86 decreased CD206 expression, modulated cytokine mRNA levels. RNA sequencing analysis post substantial number DEGs enriched pathway. through significant upregulation downregulation alongside inhibitor Fer-1 abrogated these effects, highlighting specificity β-glucan-mediated polarization. Conclusion: These results collectively provide novel insights into immunotherapeutic potential modulating offering promising avenue for strategies. Keywords: β-glucan, cancer, macrophage polarization, C.

Язык: Английский

Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation DOI
Jeong‐Hoon Jang,

Do-Hee Kim,

Kyung‐Soo Chun

и другие.

Archives of Pharmacal Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 31, 2025

Язык: Английский

Процитировано

1

Wound healing: insights into autoimmunity, ageing, and cancer ecosystems through inflammation and IL-6 modulation DOI Creative Commons
Lukáš Lacina, Michal Kolář, Lucie Pfeiferová

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 29, 2024

Wound healing represents a complex and evolutionarily conserved process across vertebrates, encompassing series of life-rescuing events. The runs in three main phases: inflammation, proliferation, maturation/remodelling. While acute inflammation is indispensable for cleansing the wound, removing infection, eliminating dead tissue characterised by prevalence neutrophils, proliferation phase transition into inflammatory cell profile, shifting towards macrophages. involves development granulation tissue, comprising fibroblasts, activated myofibroblasts, endothelial cells. Communication among these cellular components occurs through intercellular contacts, extracellular matrix secretion, as well paracrine production bioactive factors proteolytic enzymes. intricately regulated particularly interleukin-6. Prolonged results dysregulations during formation may lead to chronic wounds or hypertrophic/keloid scars. Notably, pathological processes such autoimmune organ fibrosis, tumour microenvironment, impaired repair following viral infections notably share morphological functional similarities with tissue. Consequently, wound emerges prototype understanding diverse processes. prospect gaining comprehensive holds potential furnish fundamental insights modulation intricate dialogue between cancer cells non-cancer within ecosystem. This knowledge pave way innovative approaches diagnostics, disease monitoring, anticancer therapy.

Язык: Английский

Процитировано

4

Autocrine and paracrine LIF signals to collaborate Sorafenib-resistance in Hepatocellular Carcinoma and effects of Kanglaite Injection DOI
Yingying Shao,

Weiling Pu,

Ranran Su

и другие.

Phytomedicine, Год журнала: 2024, Номер 136, С. 156262 - 156262

Опубликована: Ноя. 15, 2024

Язык: Английский

Процитировано

2

Candida albicans-Derived β-Glucan as a Novel Modulator of Tumor Microenvironment: Targeting Macrophage Polarization and Inducing Ferroptosis in Lung Cancer DOI Creative Commons
Xiang He,

Ran Qin,

Xiaolan Li

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 10479 - 10494

Опубликована: Дек. 1, 2024

Introduction: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment (TME), and their polarization state significantly influences patient outcomes. This study investigates inhibitory effects of β-glucan extracted from Candida albicans on lung cancer progression, focusing its impact TAM induction ferroptosis, form regulated cell death. Methods: Utilizing both vivo animal models vitro cellular assays, we assessed growth, proliferation, migration. We evaluated by analyzing expression M1 M2 markers identified differentially expressed genes (DEGs) related to ferroptosis. The ferroptosis was further confirmed assessing protein levels ACSL4 GPX4, intracellular ferrous ion levels, lipid peroxides. Results: treatment reduced size weight, along with proliferation migration, suggesting potent suppressive effect growth. promoted an M1-like phenotype TAMs, as evidenced increased CD86 decreased CD206 expression, modulated cytokine mRNA levels. RNA sequencing analysis post substantial number DEGs enriched pathway. through significant upregulation downregulation alongside inhibitor Fer-1 abrogated these effects, highlighting specificity β-glucan-mediated polarization. Conclusion: These results collectively provide novel insights into immunotherapeutic potential modulating offering promising avenue for strategies. Keywords: β-glucan, cancer, macrophage polarization, C.

Язык: Английский

Процитировано

1