Topical Agents in Biofilm Disaggregation: A Systematic Review and Meta-Analysis
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(8), С. 2179 - 2179
Опубликована: Апрель 10, 2024
Background:
to
evaluate
the
effectiveness
of
different
topical
agents
in
biofilm
disaggregation
during
non-surgical
periodontal
therapy.
Methods:
search
strategy
was
conducted
according
PRISMA
2020
on
Pubmed,
Cochrane
Library,
Scopus,
and
Web
Science,
it
registered
PROSPERO,
ID:
CRD42023474232.
It
included
studies
comparing
therapy
(NSPT)
with
without
application
for
disruption.
A
risk
bias
analysis,
a
qualitative
quantitative
analysis
were
performed.
Results:
out
1583
records,
11
articles
included:
10
randomized
clinical
trials
one
retrospective
analysis.
The
total
number
participants
considered
study
386.
primary
outcomes
probing
pocket
depth
(PPD),
attachment
level
(CAL),
bleeding
indices.
secondary
plaque
indices,
gingival
recessions,
microbiological
parameters.
meta-analysis
revealed
following:
[Weighted
mean
difference
(WMD):
−0.37;
95%
confidence
interval
(CI)
(−0.62,
−0.12),
heterogeneity
I2:
79%,
statistical
significance
p
=
0.004].
Conclusions:
reduction
(PPD)
between
baseline
follow-up
at
3–6
months
showed
statistically
significant
result
favor
sulfonated
phenolics
gel.
scientific
evidence
is
still
limited
heterogeneous;
further
are
required.
Язык: Английский
The Use of Hyaluronic Acid in the Non-Surgical Treatment of Periodontitis—An Umbrella Review
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 998 - 998
Опубликована: Апрель 20, 2025
Background:
Periodontitis
is
a
prevalent
inflammatory
condition
that
destroys
periodontal
tissues.
Scaling
and
root
planing
(SRP)
the
gold
standard
for
non-surgical
treatment;
however,
its
efficacy
may
be
limited
in
cases
with
complex
dental
issues.
This
umbrella
review
aims
to
evaluate
effectiveness
of
hyaluronic
acid
(HA)
as
an
adjunct
scaling
enhancing
clinical
outcomes
periodontitis
management.
Methods:
A
comprehensive
five
systematic
reviews,
including
meta-analyses
where
available,
was
conducted
synthesize
evidence
on
adjunctive
use
HA
SRP.
The
studies
were
evaluated
using
AMSTAR-2
quality
assessment
tool
determine
methodological
rigor.
Data
parameters
such
probing
depth
(PD),
attachment
level
(CAL),
bleeding
(BOP),
gingival
index
(GI),
plaque
(PI)
extracted
analyzed.
Results:
findings
indicate
supplementation
leads
moderate
improvements
PD,
CAL,
BOP,
GI,
PI
compared
SRP
alone.
Notable
reductions
PD
gains
CAL
observed,
some
showing
statistically
significant
benefits.
However,
heterogeneity
concentrations
(0.2–1.4%),
application
methods,
treatment
frequencies,
follow-up
durations
(1
week
12
months)
limits
definitive
conclusions.
Additionally,
did
not
significantly
affect
reduction
P.
gingivalis
prevalence.
Conclusions:
conjunction
shows
promise
therapy.
methodologies
indicates
necessity
high-quality,
standardized
randomized
controlled
trials
establish
clear
guidelines
periodontitis.
Язык: Английский
Comparative Study of Systemic vs. Local Antibiotics with Subgingival Instrumentation in Stage III–IV Periodontitis: A Retrospective Analysis
Antibiotics,
Год журнала:
2024,
Номер
13(5), С. 430 - 430
Опубликована: Май 9, 2024
To
improve
the
clinical
and
microbiological
outcomes
of
non-surgical
mechanical
periodontal
therapy,
adjunctive
use
antimicrobials
has
been
utilized
in
treating
moderate-to-severe
periodontitis.
In
our
study,
retrospective
design
included
previously
collected
health-related
patient
data,
obtained
from
printed
digital
charts
patients
who
received
systemic
or
local
antibiotic
adjuncts
to
SI
(subgingival
instrumentation).
A
total
34
(diagnosed
with
generalized
Stage
III/IV
periodontitis)
met
inclusion
exclusion
criteria
were
evaluated.
The
samples
tested
for
following
bacterial
strains:
Aggregatibacter
actinomycetemcomitans
(A.
actinomycetemcomitans),
Porphyromonas
gingivalis
(P.
gingivalis),
Prevotella
intermedia
intermedia),
Tanererella
forsythia
(T.
forsythia),
Treponema
denticola
denticola).
inter-group
comparisons
species
did
not
show
statistically
significant
differences
between
groups.
present
study
aimed
evaluate
effects
after
systemically
administered
(SA)
AMX
(amoxicillin)
+
MET
(metronidazole)
(administered
7
days),
locally
delivered
(LDD)
piperacillin
tazobactam
step
2
therapy.
Results:
Overall,
all
parameters
improved
groups,
a
difference
comparison
regarding
full-mouth
bleeding
score
(FMBS)
(p
<
0.05)
favor
SA
group,
p-value
0.05
was
considered
be
significant.
Statistically
PPD
(probing
pocket
depth)
reductions
CAL
(clinical
attachment
level)
gains
observed
both
groups
at
3-month
follow-up.
conclusion,
within
limitations,
this
suggest
that
SI,
provided
comparable
improvements.
Systemic
protocols
more
efficacious
regard
reduction
FMBS.
Follow-up
studies
larger
numbers
are
needed
further
investigate
effect.
Язык: Английский
Clinical, Microbiological, and Biochemical Outcomes of Hyaluronic Acid in Non-Surgical Periodontal Therapy: A Systematic Review and Meta-Analysis
Applied Sciences,
Год журнала:
2025,
Номер
15(11), С. 5975 - 5975
Опубликована: Май 26, 2025
Aim:
This
systematic
review
and
meta-analysis
evaluated
the
adjunctive
use
of
hyaluronic
acid
(HA)
in
non-surgical
periodontal
therapy
to
improve
clinical
outcomes
patients
with
moderate-to-severe
chronic
periodontitis.
The
aim
was
assess
its
effectiveness
reducing
probing
pocket
depth
(PPD),
improving
attachment
level
(CAL),
decreasing
bleeding
on
(BOP).
Methods:
Four
electronic
databases
were
searched
(PubMed,
Cochrane
Library,
Scopus,
Web
Science,
Grey
Literature)
for
randomized
controlled
trials
(RCTs)
published
until
January
2025
involving
otherwise
healthy
treated
scaling
root
planing
(SRP)
plus
HA
after
at
least
12
weeks
follow-up.
Risk
bias
assessed
using
RoB
2.0;
data
collected
assessment,
microbiological,
biochemical
analysis
then
analyzed
a
fixed-effects
or
random-effects
model
considering
high
heterogeneity
included
studies,
which
calls
caution
when
interpreting
results.
Results:
Fourteen
21
RCTs
reviewed
underwent
meta-analysis.
Compared
SRP
alone,
addition
≥
0.8%
led
an
improvement
PPD,
but
reduction
BOP
less
consistent.
Biochemical
markers
indicated
inflammation,
oxidative
stress,
selective
antimicrobial
activity.
Although
studies
0.2%
are
still
limited,
improvements
have
been
observed
parameters,
along
better
microbiological
experimental
group
compared
control
group.
Conclusions:
Despite
moderate
methodological
limitations,
evidence
supports
combined
treatment.
Язык: Английский
Treatment of periodontal diseases: Latin America and the Caribbean Consensus 2024
Brazilian Oral Research,
Год журнала:
2024,
Номер
38(suppl 1)
Опубликована: Янв. 1, 2024
The
prevalence
of
periodontitis
in
Latin
American
and
Caribbean
countries
(LACC)
drew
attention
to
a
significant
public
health
issue
exacerbated
by
socio-economic
disparities.
This
consensus
report,
based
on
the
European
Federation
Periodontology
(EFP)
S3
level
clinical
practice
guidelines,
proposed
multifaceted
approach
periodontal
health-care.
report
highlighted
critical
need
for
holistic,
population-wide
policies
underscored
lack
documented
community
interventions
contemporary
literature.
advocated
patient-centered
care,
with
non-surgical
surgical
interventions,
long-term
commitment
supportive
care
(SPC).
It
emphasized
importance
patient
engagement
biofilm
control
means
home-care
professional
health.
also
stressed
that
subgingival
instrumentation
benefits
even
severely
compromised
teeth,
significantly
reducing
probing
depths
gingival
inflammation.
Moreover,
it
personalized,
SPC
maintaining
oral
post-treatment,
pointed
out
identify
factors
influencing
adherence.
aim
this
was
provide
actionable
guidance
clinicians
policymakers,
focused
improving
outcomes
quality
life
LACC.
Язык: Английский
Formulation and Release of Active Pharmaceutical Ingredients using a Supramolecular Self‐healing Two‐component Gel
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
A
two‐component
low‐molecular‐weight
gelator
(LMWG)
formed
from
a
modified
amino
acid
and
an
aldehyde
was
formulated
with
active
pharmaceutical
ingredients
(APIs).
Basic
APIs
(propranolol,
atropine)
can
be
mixed
the
LMWG
prior
to
gel
assembly
while
acidic
(naproxen,
rosuvastatin)
inhibit
by
disrupting
imine
bond
were
loaded
diffusion
after
assembly.
For
diffusion‐loaded
gels,
API
in
liquid‐like
phase
rapidly
released,
remainder,
interacting
fibres,
retained
gel.
Rosuvastatin
release
particularly
low
Saturation
Transfer
Difference
(STD)
NMR
indicating
interactions
between
aromatic
ring
self‐assembled
network.
Propranolol
also
interacted
via
its
unit,
led
erosion.
Using
agarose
as
polymer
additive
reinforced
gel,
restricting
In
contrast,
atropine
readily
released
over
period
of
hours
‐
it
is
primarily
STD
no
The
atropine‐loaded
thixotropic
properties.
Overall,
must
carefully
chosen
optimise
formulation/release.
Of
investigated,
has
most
potential
for
further
development.
Atropine
applications
treating
myopia,
our
results
suggest
ophthalmic
supramolecular
gels.
Язык: Английский
Comparison and Estimation of Salivary sTREM-1 and IL-1β in Periodontitis and Diabetes Mellitus Patients before and after Nonsurgical Periodontal Therapy using Hyaluronic Acid and Diode LASER: A Clinical Trial
Journal of Pharmacology and Pharmacotherapeutics,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
Background
Periodontal
disease
is
a
chronic
inflammatory
that
activates
the
innate
immune
response.
Activation
of
TREM-1
signaling
pathway
promotes
synthesis
cytokines
like
interleukin-1
beta
(IL-1β),
tumor
necrosis
factor-α
(TNF-α),
interleukin-6
(IL-6)
and
interleukin-8
(IL-8).
Hyaluronic
acid
(HA)
can
be
used
to
treat
periodontitis
as
an
adjunct
mechanical
debridement
due
its
healing
properties.
Purpose
To
evaluate
compare
soluble
triggering
receptor
expressed
on
myeloid
cells
(sTREM-1)
IL-1β
in
patients
with
without
diabetes
mellitus
before
after
nonsurgical
periodontal
therapy
using
conventional
root
planing
adjuncts
HA
(Gengigel
®
)
diode
LASER
(940
nm).
Methods
Chronic
were
allocated
groups
based
(groups
I
II),
respectively.
Assessment
parameters:
probing
depth
(PPD),
clinical
attachment
loss
(CAL),
plaque
index
(PI),
gingival
bleeding
(GBI),
surface
area
(PISA)
done.
About
5
mL
unstimulated
whole
saliva
was
collected
from
every
patient
at
baseline
1
month.
Patients
subgrouped
treatment
protocol
(subgroup
A:
scaling
(SRP),
subgroup
B:
SRP
+
(0.8%
Gengigel
),
C:
940
nm
LASER).
The
primary
secondary
outcomes
determined.
Results
Intragroup
comparison
group
showed
statistical
significance
parameters
subgroups
B
C.
II
all
three
subgroups.
Intergroup
III
salivary
biomarker
levels
A–C
Conclusion
Therefore,
within
study’s
limitations,
use
had
additional
improvement
biomarkers
over
planing.
Язык: Английский
Comparison of efficacies of azithromycin & doxycycline as local drug delivery agents in treatment of chronic periodontitis − A clinical and microbiological study
Deepika Pawar Chandrashekara Rao,
Nagarjuna Reddy YV,
Swet Nisha
и другие.
International journal of Nutrition Pharmacology Neurological Diseases,
Год журнала:
2023,
Номер
13(4), С. 243 - 249
Опубликована: Окт. 1, 2023
Introduction:
Periodontitis
causes
tissue
destruction
and
host-microbial
interactions
can
lead
to
dysbiosis.
Nonsurgical
periodontal
therapy
helps
in
eliminating
microbial
insult
adjunctive
therapies
like
local
drug
administration
comprising
of
antibiotics,
pre-
probiotics
herbal
better
healing.The
present
study
aims
at
evaluation
efficacy
0.5%
azithromycin
(AZM)
5%
doxycycline
(DOX)
as
delivery
agents
the
treatment
chronic
periodontitis.
Materials
methods:
A
total
66
subjects
diagnosed
with
periodontitis
were
enrolled
this
study.
The
randomly
allocated
into
three
groups.
Group
consisted
22
who
received
full-mouth
scaling
root
planing
AZM
gel,
B
DOX
C
only
planing.
Results:
gel
after
significantly
reduced
clinical
microbiological
parameters
compared
group
(
p
<
0.05%);
however,
intergroup
comparison
between
two
drugs
didn’t
show
any
significant
difference
>
0.05%).
Conclusion:
use
had
enhanced
results
alone.
Язык: Английский