Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization
Phytomedicine,
Год журнала:
2024,
Номер
129, С. 155635 - 155635
Опубликована: Апрель 20, 2024
Cerebral
ischemia-reperfusion
(I/R)
injury
often
leads
to
neuronal
death
through
persistent
neuroinflammatory
responses.
Recent
research
has
unveiled
a
unique
inflammatory
programmed
cell
mode
known
as
PANoptosis.
However,
direct
evidence
for
PANoptosis
in
ischemic
stroke-induced
not
been
established.
Although
it
is
widely
thought
that
modulating
the
balance
of
microglial
phenotypic
polarization
cerebral
I/R
could
mitigate
neuroinflammation-mediated
death,
remains
unknown
whether
influences
PANoptotic
triggered
by
I/R.
Our
prior
study
demonstrated
curcumin
(CUR)
preconditioning
boost
neuroprotective
properties
olfactory
mucosa-derived
mesenchymal
stem
cells
(OM-MSCs)
intracerebral
hemorrhage.
Yet,
potential
capacity
curcumin-pretreated
OM-MSCs
(CUR-OM-MSCs)
on
reducing
during
uncertain.
To
mimic
injury,
We
established
vivo
models
reversible
middle
artery
occlusion
(MCAO)
C57BL/6
mice
and
vitro
oxygen-glucose
deprivation/reoxygenation
(OGD/R)
HT22
neurons
BV2
microglia.
findings
indicated
caused
microglia
adopt
an
M1
(pro-inflammatory)
phenotype
both
vitro.
Curcumin
pretreatment
enhanced
proliferation
anti-inflammatory
OM-MSCs.
The
CUR-OM-MSCs
group
experienced
more
pronounced
reduction
better
recovery
neurological
function
than
group.
Bioinformatic
analysis
revealed
microRNA-423-5p
(miRNA-423-5p)
expression
was
obviously
upregulated
compared
treatment
induced
switch
M2
(anti-inflammatory)
releasing
miRNA-423-5p,
which
targeted
nucleotide-binding
oligomerization
domain
2
(NOD2),
upstream
regulator
NF-kappaB
(NF-κB)
Mitogen-Activated
Protein
Kinase
(MAPK)
signaling
pathways,
attenuate
resulting
from
This
results
provide
first
demonstration
existence
conditions.
ameliorating
effect
neuroinflammation
mediated
via
upregulating
abundance
miRNA-423-5p.
intervention
effectively
alleviates
combination
with
holds
promise
potentially
efficacious
stroke
future.
Язык: Английский
Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 334 - 334
Опубликована: Март 10, 2024
Ferroptosis
is
a
recently
discovered
type
of
programmed
cell
death
that
mechanistically
different
from
other
types
such
as
apoptosis,
necroptosis,
and
autophagy.
It
characterized
by
the
accumulation
intracellular
iron,
overproduction
reactive
oxygen
species,
depletion
glutathione,
extensive
lipid
peroxidation
lipids
in
membrane.
was
ferroptosis
interconnected
with
many
diseases,
neurodegenerative
ischemia/reperfusion
injury,
cancer,
chronic
kidney
disease.
Polyphenols,
plant
secondary
metabolites
known
for
bioactivities,
are
being
extensively
researched
context
their
influence
on
which
resulted
great
number
publications
showing
need
systematic
review.
In
this
review,
an
literature
search
performed.
Databases
(Scopus,
Web
Science,
PubMed,
ScienceDirect,
Springer)
were
searched
time
span
2017
to
November
2023,
using
keyword
“ferroptosis”
alone
combination
“flavonoid”,
“phenolic
acid”,
“stilbene”,
“coumarin”,
“anthraquinone”,
“chalcone”;
after
selection
studies,
we
had
311
papers
143
phenolic
compounds.
total,
53
compounds
showed
ability
induce
ferroptosis,
110
able
inhibit
out
those
compounds,
20
both
abilities
depending
model
system.
The
most
shikonin,
curcumin,
quercetin,
resveratrol,
baicalin.
common
modes
action
modulation
Nrf2/GPX4
Nrf2/HO-1
axis
iron
metabolism.
Язык: Английский
PLGA scaffold combined with MSCs transplantation improved neural function and brain tissue structure in rats with traumatic brain injury
Na Xu,
Zihuan Sun,
Weikang Guan
и другие.
Brain Research Bulletin,
Год журнала:
2025,
Номер
unknown, С. 111216 - 111216
Опубликована: Янв. 1, 2025
Poly
(lactic-co-glycolic
acid)
(PLGA)
is
an
important
biomaterial
for
tissue
defect
repair,
but
its
application
in
replacing
missing
brain
needs
improvement.
Mesenchymal
stem
cells
(MSCs)
have
been
used
to
treat
various
neurological
diseases,
they
face
challenges
when
filling
large
defects.
The
purpose
of
this
study
was
investigate
the
effects
PLGA
combined
with
MSCs
transplantation
on
structure
and
neural
function
rats
traumatic
injury
(TBI),
explore
possible
mechanism.
results
showed
that
both
PLGA+MSCs
could
improve
promote
nerve
recovery
TBI,
being
superior
transplantation.
Furthermore,
compared
alone,
further
reduced
cell
apoptosis,
promoted
neuron
survival,
improved
synaptic
plasticity.
Overall,
adhesion
can
enhance
therapeutic
efficacy
following
TBI.
Язык: Английский
Anti-ferroptotic effects of natural polyphenols in nervous system injury: a narrative literature review
Nutritional Neuroscience,
Год журнала:
2025,
Номер
unknown, С. 1 - 16
Опубликована: Янв. 17, 2025
Recent
studies
have
shown
that
ferroptosis,
a
newly
identified
regulated
cell
death
characterized
by
increased
lipid
peroxidation
and
accumulation
of
toxic
peroxides,
is
closely
related
to
the
pathophysiological
processes
nervous
system
diseases
which
can
be
inhibited
with
iron
chelators,
lipophilic
antioxidants,
inhibitors.
To
review
current
evidence
on
efficacy
various
natural
polyphenols
in
injury.
The
data
selected
for
this
were
collected
searching
MEDLINE/PubMed,
Web
Science,
Scopus,
Google
Scholar
database
articles
published
English
between
2000
2024
using
following
terms:
death,
iron,
glutathione
peroxidase.
Natural
been
found
some
protective
effects
against
disorders,
are
attributed
variety
biological
properties,
particularly
antioxidant,
immunomodulatory,
anti-inflammatory
effects.
preclinical
conducted
use
most
common
dietary
polyphenols,
including
resveratrol,
EGCG,
curcumin,
quercetin,
gastrodin,
baicalein
&
baicalin,
carthamin,
galangin,
puerarin,
morachalcone,
carnosic
acid
molecular
mechanisms
discussed.
On
other
hand,
results
few
clinical
emphasize
primary
role
neuronal
degeneration
Some
findings
indicated
as
antioxidant
supplements
anti-ferroptotic
disorders.
Язык: Английский
Olfactory mucosa-mesenchymal stem cells with overexpressed Nrf2 modulate angiogenesis and exert anti-inflammation effect in an in vitro traumatic brain injury model
European journal of medical research,
Год журнала:
2025,
Номер
30(1)
Опубликована: Фев. 5, 2025
Язык: Английский
Olfactory mucosa mesenchymal stem cell‐derived exosomes protect against neuroinflammation after subarachnoid hemorrhage by activating mitophagy
The Kaohsiung Journal of Medical Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Abstract
Subarachnoid
hemorrhage
(SAH)
can
lead
to
significant
acute
neuroinflammation,
with
treatment
outcomes
often
being
inadequate.
Olfactory
mucosa
mesenchymal
stem
cells
(OM‐MSCs)
have
promising
therapeutic
potential
in
nerve
regeneration
and
functional
recovery.
This
investigation
sought
elucidate
the
mechanisms
through
which
exosomes
derived
from
OM‐MSCs
provide
protection
against
neuroinflammation
following
SAH.
Mouse
their
were
isolated
characterized
using
various
techniques,
including
transmission
electron
microscopy,
immunofluorescence
staining,
Western
blotting,
flow
cytometry,
nanoparticle
tracking
analysis.
Hemin‐induced
HT22
subsequently
utilized
assess
impact
of
OM‐MSC‐derived
on
inflammatory
response,
apoptosis,
mitophagy
ELISAs,
qPCR,
staining.
The
impacts
neuronal
damage
SAH
model
mice
assessed
TUNEL
Exosomes
had
capacity
reduce
levels
proinflammatory
factors
(IL‐6,
IL‐1
β
,
TNF‐
α
)
promote
apoptosis
hemin‐induced
cells.
alleviated
injury
post‐SAH,
as
evidenced
by
increase
modified
Garcia
scores,
reduction
brain
water
content,
decrease
blood–brain
barrier
permeability,
decreases
marker
levels,
rates.
Notably,
protective
effects
both
vitro
vivo,
mediated
via
activation
mitophagy.
These
findings
a
fresh
perspective
for
subsequent
clinical
research
domain
prevention
strategies.
Язык: Английский
Manipulated mesenchymal stem cell therapy in the treatment of Parkinson’s disease
Stem Cell Research & Therapy,
Год журнала:
2024,
Номер
15(1)
Опубликована: Дек. 18, 2024
Mesenchymal
stem
cell
(MSC)
therapy
has
been
considered
a
promising
approach
for
the
treatment
of
Parkinson's
disease
(PD)
several
years.
PD
is
globally
prevalent
neurodegenerative
characterized
by
accumulation
Lewy
bodies
and
loss
dopaminergic
neurons,
leading
to
severe
motor
non-motor
complications
in
patients.
As
current
treatments
are
unable
halt
progression
neuronal
dopamine
degradation,
MSC
emerged
as
highly
strategy
treatment.
This
promise
due
MSCs'
unique
properties
compared
other
types
cells,
including
self-renewal,
differentiation
potential,
immune
privilege,
secretion
neurotrophic
factors,
ability
improve
damaged
tissue,
modulation
system,
lack
ethical
concerns.
MSCs
have
employed
numerous
pre-clinical
clinical
studies
with
results.
However,
certain
aspects
their
efficacy
treating
may
benefit
from
various
genetic
epigenetic
modifications.
In
this
review
article,
we
assess
these
approaches
improving
specialized
PD.
Язык: Английский