Human & Experimental Toxicology,
Год журнала:
2025,
Номер
44
Опубликована: Фев. 1, 2025
Introduction
Sodium
dodecyl
sulfate
(SDS),
a
widely
used
surfactant
in
detergents,
has
raised
concerns
due
to
its
potential
health
risks,
particularly
children.
This
study
evaluates
the
impact
of
SDS
exposure
on
GH
secretion
GH3
cells,
focusing
oxidative
stress
as
key
mechanism.
Methods
cells
were
treated
with
varying
concentrations
(0.001–10
mM)
for
24
or
48
h.
Cell
viability
was
assessed
using
MTT
assay,
while
quantified
via
ELISA.
Oxidative
levels
evaluated
through
ROS
fluorescence
assays,
and
gene
expression
Nrf2,
IL-6,
TNF-α,
caspase-3
analyzed
qPCR.
Additionally,
antioxidant
N-acetylcysteine
(NAC)
determine
protective
effects
against
SDS-induced
stress.
Results
led
dose-dependent
decrease
cell
viability,
identified
primary
driver.
Nrf2
exhibited
biphasic
response,
showing
transient
upregulation
at
low
doses
but
suppression
higher
concentrations,
exacerbating
damage.
NAC
treatment
reduced
partially
restored
secretion,
confirming
role
toxicity.
Discussion
These
findings
suggest
that
may
disrupt
endocrine
function,
warranting
further
risk
assessment
safety
consumer
products.
Given
SDS’s
prevalence
household
products,
future
research
should
focus
long-term
children
therapeutic
interventions
mitigate
Life,
Год журнала:
2024,
Номер
14(3), С. 402 - 402
Опубликована: Март 18, 2024
We
are
exposed
to
a
mixture
of
environmental
man-made
and
natural
xenobiotics.
experience
wide
spectrum
exposure
in
our
lifetime,
including
the
effects
xenobiotics
on
gametogenesis
gametes
that
undergo
fertilization
as
starting
point
individual
development
and,
moreover,
utero
exposure,
which
can
itself
cause
first
somatic
or
germline
mutation
necessary
for
breast
cancer
(BC)
initiation.
Most
metabolized
or/and
bioaccumulate
biomagnify
tissues
cells,
tissues,
so
xenobiotic
metabolism
plays
an
important
role
BC
initiation
progression.
Many
considerations
necessitate
more
valuable
explanation
regarding
molecular
mechanisms
action
act
genotoxic
epigenetic
carcinogens.
Thus,
exposomics
exposome
concept
based
diversity
range
exposures
physical
factors,
synthetic
chemicals,
dietary
components,
psychosocial
stressors,
well
their
associated
biologic
processes
pathways.
Existing
evidence
risk
(BCR)
suggests
food-borne
chemical
carcinogens,
air
pollution,
ionizing
radiation,
socioeconomic
status
closely
related
carcinogenesis.
The
aim
this
review
was
depict
dynamics
kinetics
several
involved
development,
emphasizing
new
omics
fields
exposomics,
such
toxicogenomics,
epigenomics
interactomics,
metagenomics,
nutrigenomics,
nutriproteomics,
nutrimiRomics.
mainly
focused
food
nutrition,
endocrine-disrupting
chemicals
(EDCs),
development.
Overall,
cell
tissue
accumulation
biotransformation
lead
modifications
composition
morphology,
DNA
damage
genomic
instability,
epimutations,
RNA-mediated
extracellular
vesicle
effects,
aberrant
blood
methylation,
stimulation
epithelial-mesenchymal
transition
(EMT),
disruption
cell-cell
junctions,
reorganization
actin
cytoskeleton,
metabolic
reprogramming,
overexpression
mesenchymal
genes.
Moreover,
into
cells
impacts
almost
all
known
carcinogenic
Conversely,
food,
there
many
bioactive
compounds
with
anti-cancer
potential,
exerting
pro-apoptotic
roles,
inhibiting
cycle
progression
proliferation,
migration,
invasion,
damage,
stress
conditions.
conclude
has
high
potential
demonstrate
how
acts
double-edged
sword,
promoting
suppressing
tumorigenesis
BC.
Biofuel Research Journal,
Год журнала:
2024,
Номер
11(02), С. 2105 - 2145
Опубликована: Июнь 1, 2024
As
climate
change
intensifies
and
the
need
to
reduce
human-caused
emissions
becomes
more
urgent,
transitioning
a
bio-based
economy
is
essential.
This
paper
explores
diverse
industrial
applications
of
plant
oils
as
sustainable
alternatives
petroleum-based
products,
including
their
use
in
food,
polymers,
lubricants,
surfactants,
pesticides,
emollients,
biofuels.
review
delves
into
biosynthetic
pathways,
detailing
key
enzymes
processes
involved
synthesis
triacylglycerol.
It
thoroughly
discusses
how
genetic
metabolic
engineering
can
not
only
increase
oil
yields
but
also
modify
fatty
acid
compositions
better
meet
requirements.
By
understanding
genetics
utilizing
advanced
biotechnologies,
content
quality
sources
be
significantly
enhanced,
aligning
with
both
sustainability
goals
demands.
provides
comprehensive
overview
current
uses
production,
proposing
innovative
strategies
such
from
biomass
or
cultivating
non-edible
crops.
These
approaches
aim
establish
system,
reliance
on
fossil
fuels,
promote
growth
an
environmentally
responsible
economy.
Additionally,
highlights
future
directions,
examining
economic
implications
environmental
benefits
adopting
across
various
sectors
positioning
them
pivotal
achieving
eco-friendly,
Foods,
Год журнала:
2023,
Номер
12(24), С. 4386 - 4386
Опубликована: Дек. 6, 2023
Water,
soil,
and
food
products
contain
pesticide
residues.
These
residues
result
from
excessive
pesticides
use,
motivated
by
the
fact
that
agricultural
productivity
can
be
increased
use
of
these
pesticides.
The
accumulation
in
body
cause
health
problems,
leading
to
safety
concerns.
Cold
plasma
technology
has
been
successfully
employed
various
applications,
such
as
seed
germination,
bacterial
inactivation,
wound
disinfection,
surface
sterilization,
degradation.
In
recent
years,
researchers
have
increasingly
explored
effectiveness
cold
degradation
Most
studies
shown
promising
outcomes,
encouraging
further
research
scaling-up
for
commercialization.
This
review
summarizes
an
emerging
terms
system
configuration.
It
also
outlines
key
findings
this
area.
most
frequently
adopted
systems
each
application
are
identified,
mechanisms
underlying
using
discussed.
possible
factors
influencing
efficiency,
challenges
research,
future
trends
demonstrates
despite
nascent
nature
technology,
shows
considerable
potential
regards
residue
degradation,
particularly
applications.
Foods,
Год журнала:
2024,
Номер
13(8), С. 1151 - 1151
Опубликована: Апрель 10, 2024
Hydroponic
cultivation
of
fresh
produce
is
gaining
popularity
worldwide,
but
few
studies
have
provided
a
comparative
assessment
hydroponic
and
conventional
soil-based
vegetables.
In
this
study,
we
analyzed
series
hazardous
chemicals,
including
120
pesticides,
18
phthalates
(PAEs),
2
heavy
metals
(lead
cadmium)
in
four
vegetable
commodities
(lettuces,
celeries,
tomatoes,
cucumbers)
from
cultivation.
Our
study
showed
that
at
least
one
pesticide
was
present
84%
the
conventionally
grown
samples,
whereas
only
30%
samples
contained
detectable
residues.
Regarding
total
PAE
concentrations,
there
no
significant
difference
between
The
lead
cadmium
residues
cultivated
vegetables
were
significantly
higher
than
those
produced
Lead
primary
metal
pollutant
across
all
samples.
hazard
index
(HI)
values
0.22
0.64,
respectively.
Since
both
are
below
one,
exposure
to
these
chemicals
through
consumption
studied
may
not
pose
health
risk.
HI
also
suggested
risks
eating
lower
for
