IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 28, 2024
Exercise
has
long
been
thought
to
improve
overall
cognitive
and
brain
health,
it
may
protect
against
dementia
by
increasing
blood
flow
the
brain.
Prospective
cohort
studies
support
idea
that
starting
physical
activity
as
a
young
adult
continuing
throughout
life
is
connected
with
lower
risk
of
impairment.
While
presence
link
between
fitness
health
known,
only
in
recent
years
research
begun
study
role
on
memory
performance.
This
focused
effects
aerobic
training
cognition
because
demonstrated
affect
plasticity
structure
while
also
improving
structure.
For
example,
one
found
gene
linked
brain-derived
neurotrophic
factors
affected
learning
individual
differences
recognition
memory.
Thus,
issue
remains:
would
strength
result
neurobiological
gains
effects?
Can
we
discover
measurable
markers
distinguish
older
persons
who
benefit
significantly
from
resistance
(RT)
those
little
or
none?
Current Opinion in Neurology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Purpose
of
review
The
present
aims
to
provide
an
overview
the
existing
understanding
role
gut
microbiome
in
Alzheimer's
disease
pathophysiology.
Recent
findings
research
has
highlighted
significant
pathogenesis
via
gut-brain
axis.
However,
precise
mechanisms
by
which
and
its
microbial
metabolites
influence
brain
function
are
not
clearly
understood.
Various
factors,
such
as
diet,
drugs,
lifestyle,
stress,
infections
can
provoke
imbalance
homeostasis,
known
dysbiosis.
This
dysbiosis
impacts
intestinal
blood-brain
barrier
permeability,
elevating
pro-inflammatory
cytokines
contributing
neurodegeneration.
Moreover,
generates
neurotransmitters,
amyloids,
neurotoxins,
metabolites,
may
play
a
systemic
inflammation
disruption
physiological
barriers.
Summary
In
past
decade,
advancements
analysis
technologies
bioinformatics
have
significantly
enhanced
our
disease.
plays
pivotal
regulatory
progression
disease,
closely
interacts
with
pathogenesis,
encompassing
inflammation,
amyloidosis,
neurodegeneration,
tauopathy,
co-pathologies.
Marine Drugs,
Год журнала:
2025,
Номер
23(2), С. 83 - 83
Опубликована: Фев. 14, 2025
The
cosmeceutical
industry
has
increasingly
turned
its
attention
to
marine
macroalgae,
recognizing
their
significant
bioactive
potential
as
sources
of
natural
compounds
for
skincare
applications.
A
growing
number
products
now
incorporate
extracts
or
isolated
from
various
macroalgae
species.
However,
many
species
remain
underexplored,
highlighting
a
valuable
opportunity
further
research.
Among
these,
Caulerpa
prolifera
(Forsskål)
J.V.
Lamouroux
emerged
promising
candidate
This
study
provides
the
most
comprehensive
phytochemical
assessment
C.
date,
revealing
source
and
compounds.
analysis
identified
key
components
lipophilic
profile,
predominantly
saturated
unsaturated
fatty
acids,
alongside
di-(2-ethylhexyl)
phthalate-an
endocrine
disruptor
potentially
biosynthesized
bioaccumulated
by
algae.
While
crude
extract
exhibited
moderate
tyrosinase
inhibitory
activity,
overall
antioxidant
capacity
was
limited.
Fractionation
extract,
however,
yielded
subfractions
with
distinct
bioactivities
linked
changes
in
chemical
composition.
Notably,
enhanced
activities
against
elastase
collagenase
were
observed
enriched
1-octadecanol
only
traces
phthalate.
Conversely,
activity
diminished
loss
specific
such
β-sitosterol,
erucic
acid,
nervonic
lignoceric
acid.
work
advances
understanding
relationship
between
composition
bioactivities,
emphasizing
ingredients,
leading
more
valorization
this
macroalga.
Polymers,
Год журнала:
2025,
Номер
17(5), С. 638 - 638
Опубликована: Фев. 27, 2025
Skin
aging
is
a
complex
and
multifactorial
process
influenced
by
both
intrinsic
extrinsic
factors.
The
periorbital
area
of
the
face
particularly
susceptible
to
premature
signs
due
its
delicate
skin
structure,
major
concern
for
many
individuals.
While
hyaluronic
acid
(HA)-based
dermal
filler
products
are
commonly
used
rejuvenation,
novel
approaches
effectively
locally
address
visible
available.
This
study
aimed
investigate
Innovyal
Regenerative
Action
(IRA),
an
injectable
polynucleotide-HA
(PN-HA)
regenerative
designed
periocular
prejuvenation.
Firstly,
PN-HA
was
compared
other
commercially
available
HA-based
dermbooster
(Profhilo®,
Suisselle
Cellbooster®
Glow,
NCTF®
135
HA)
in
terms
rheological
properties,
vitro
antioxidant
capacity,
total
collagen
production
stimulation
human
fibroblasts.
Secondly,
clinical
effects
IRA
were
evaluated
two
case
reports
(monotherapy
prejuvenation).
It
shown
that
outperformed
comparators
relative
behavior
(biophysical
attributes
normalized
polymer
contents),
activity
(CUPRAC,
FRAP,
ORAC
assays),
as
well
level
induction
(72-h
fibroblast
model).
Generally,
results
this
provided
mechanistic
preliminary
insights
into
potential
benefits
cutaneous
treatment.
Overall,
it
underscored
combining
structural
support
properties
PN
with
hydrating
volumizing
HA
bares
tangible
quality
enhancement
prejuvenation
particular.
Marine Drugs,
Год журнала:
2025,
Номер
23(4), С. 165 - 165
Опубликована: Апрель 11, 2025
Aging
is
a
natural
process
resulting
in
the
progressive
impairment
of
multiple
functions
human
body,
leading
to
decline
cellular
functionality
and
development
aging-related
diseases.
External
stress
factors,
such
as
ultraviolet
(UV)
radiation,
pollution,
toxin
exposure,
increase
oxidative
stress,
damage
repair
mechanisms,
speed
up
aging
processes.
With
rise
world’s
population,
there
are
enlarged
demands
for
use
sustainable
products
food,
nutrient
supplements
cosmetics
that
can
slow
down
prolong
healthy
life
longevity.
Algae,
including
both
macroalgae
microalgae,
have
been
recognised
source
valuable
proteins,
amino
acids,
fatty
vitamins,
minerals
useful
consumption
medical
applications.
increasing
nutraceutical
pharmaceutical
bioproducts
from
environmentally
friendly
resources,
biotechnological
industry,
over
recent
decades,
has
had
provide
new,
advanced
solutions
using
modern
high-throughput
omics
technologies.
The
application
proteomics
area
discoveries
with
anti-aging
properties
become
more
popular
wide
industry
New
profiling
provides
better
understanding
changes
occurring
protein
peptide
content,
their
structure,
function
interactions,
well
regulatory
processes
molecular
pathways.
Mass
spectrometry-based
used
range
applications
identification,
characterisation,
quantification
proteins
within
proteome
sub-proteome.
chemical
facilitated
identification
approach
included
synthesis
probes
target
fishing,
allowing
interest.
This
review
focuses
on
marine
macro-
microalgal
compounds
novel
approaches,
providing
experimental
evidence
involvement
should
facilitate
innovative
approaches
Antioxidants,
Год журнала:
2023,
Номер
12(11), С. 2010 - 2010
Опубликована: Ноя. 17, 2023
In
recent
years,
there
has
been
a
focus
on
breeding
wheat
with
high
anthocyanin
levels
in
order
to
improve
food
quality
and
human
health.
The
objective
of
this
study
was
examine
the
antioxidant
geroprotective
properties
bran
extracts
using
both
vitro
vivo
research
methods.
Two
lines
were
used:
one
uncolored
pericarp
(anthocyanin-free)
another
colored
(anthocyanin-containing).
These
differed
specific
region
chromosome
2A
containing
Pp3/TaMyc1
gene,
which
regulates
production.
High-performance
liquid
chromatography-mass
spectrometry
revealed
presence
cyanidin
glucoside
arabinoside
anthocyanin-containing
extract
(+AWBE),
while
no
anthocyanins
found
anthocyanin-free
(−AWBE).
+AWBE
showed
higher
radical
scavenging
activity
(DPPH
ABTS
assays)
membrane
protective
(AAPH
oxidative
hemolysis
model)
compared
−AWBE.
Both
extended
lifespan
female
Drosophila,
indicating
properties.
This
demonstrates
that
have
effects.
However,
other
secondary
metabolites
can
also
contribute
its
potential.
Photodermatology Photoimmunology & Photomedicine,
Год журнала:
2025,
Номер
41(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Objective
Exosomes
(Exos)
from
adipose
derived
stem
cells
(ADSCs)
can
delay
skin
photoaging,
but
their
effects
on
reactive
oxygen
species
(ROS)
remains
unclear.
This
study
aimed
to
investigate
the
relationship
between
cell
exosomes
(ADSCs‐Exos)
in
anti‐photoaging
of
and
glutathione
(GSH)/
ROS
expression
human
fibroblasts.
Methods
A
photoaging
model
was
established
by
irradiating
fibroblasts
with
ultraviolet
B
(UVB)
light
vitro.
Next,
ADSCs
were
isolated
for
treating
photoaged
Afterwards,
alterations
analyzed
a
series
assays
including
senescence‐associated
β‐galactosidase
(SA‐β‐Gal)
staining,
p16
expression,
GSH
content.
Results
After
fibroblast
subjected
ADSCs‐Exos
treatment,
we
found
that
high
concentration
exosome
group
had
highest
Cellular
staining
showed
levels
SA‐β‐Gal,
p16,
concentration‐treated
lower
than
other
groups.
Conclusions
protect
via
increasing
ratio
GSH/ROS.
Genes,
Год журнала:
2024,
Номер
15(12), С. 1599 - 1599
Опубликована: Дек. 14, 2024
Background/Objectives:
Aging
is
a
natural
physiological
process
involving
biological
and
genetic
pathways.
Growing
evidence
suggests
that
alterations
in
the
epigenome
during
aging
result
transcriptional
changes,
which
play
significant
role
onset
of
age-related
diseases,
including
cancer,
cardiovascular
disease,
diabetes,
neurodegenerative
disorders.
For
this
reason,
epigenetic
diseases
have
been
reviewed,
major
extrinsic
factors
influencing
these
identified.
In
addition,
gut
microbiome
its
metabolites
as
modifiers
has
addressed.
Results:
Long-term
exposure
to
such
air
pollution,
diet,
drug
use,
environmental
chemicals,
microbial
infections,
physical
activity,
radiation,
stress
provoke
changes
host
through
several
endocrine
immune
pathways,
potentially
accelerating
process.
Diverse
studies
reported
plays
critical
regulating
brain
cell
functions
DNA
methylation
histone
modifications.
The
interaction
between
genes
serves
source
adaptive
variation,
contributing
phenotypic
plasticity.
However,
molecular
mechanisms
signaling
pathways
driving
are
still
not
fully
understood.
Conclusions:
Extrinsic
potential
inducers
alterations,
may
important
implications
for
longevity.
an
effector
gene
expression
modifications,
while
bidirectional
interactions
with
underexplored
roles
non-bacterial
microorganisms
fungi
viruses
highlight
need
further
research.
