Science in One Health, Год журнала: 2024, Номер unknown, С. 100078 - 100078
Опубликована: Сен. 1, 2024
Язык: Английский
Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 649 - 658.e1
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Egyptian Journal of Medical Human Genetics, Год журнала: 2024, Номер 25(1)
Опубликована: Ноя. 11, 2024
Abstract The Ebola virus (EBOV) remains a major public health challenge due to its complex structure and the lack of appropriate effective vaccines therapies. This review characterizes virus, immune response, therapeutic challenges. Structural EBOV proteins include envelope glycoprotein, nucleoprotein, RNA polymerase L, viral VP30, VP24, VP35, VP40. play role in virus’s pathogenesis by evading host's response. system evasion mechanisms are critical pathogenesis. Some vaccines, such as recombinant vesicular stomatitis virus-Zaire (RVSV-ZEBOV), have proven be very been approved Food Drug Administration (FDA) additionally, four other including Gam Evac-Combi (licensed Russia), ad5-EBOV (approved China), Zabdeno Mvabea Europe). However, some challenges remain developing selection immunogens, cross-protecting immunity, long-term protection, mechanism rapid response vaccination. Despite progress made, there is still need for an vaccine that offers durable broad protection against multiple strains virus. will achieved through collaboration various organizations government Non-Governmental Organization (NGO) agencies.
Язык: Английский
Процитировано
3
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Фев. 19, 2024
Abstract Background: Malaria and Ebola co-infection refers to the simultaneous presence of malaria parasite (Plasmodium) virus within an individual's body. Methodology: This study establishes epidemiological model employing non-linear differential equations assess disease transmission via reproduction number R0, stability, sensitivity analysis. The conclusion is that disease-free equilibrium point exists at specific values locally asymptotically stable when R0 less than one, while globally under same conditions. Results: Sensitivity analysis indicates parameters such as 'a', 'μh', 'γD', 'βD' have a substantial impact on number. simulated results highlight increased contact between individuals infected with amplifies rates. Furthermore, malaria-infected deceased patients, mosquito bite rates ('a'), probability from mosquitoes susceptible humans ('b') all contribute co-infections. Conclusion future work: model's capabilities include forecasting total cases, mortality rates, providing information spread co-infection. Recommendations involve environmental alterations achieve state. Future work entails extending by introducing treatment or prevention compartments address co-infections malaria. research significantly contributes understanding dynamics, emphasising need for strategic measures mitigate
Язык: Английский
Процитировано
2
Опубликована: Авг. 29, 2024
Shrews (Soricidae) are common small wild mammals. Some species of shrews, such as Asian house shrews (Suncus murinus), have a significant overlap in their habitats with humans and domestic animals. Currently, over 190 viruses 32 families, including Adenoviridae, Arenaviridae, Arteriviridae, Astroviridae, Anelloviridae, Bornaviridae, Caliciviridae, Chuviridae, Coronaviridae, Filoviridae, Flaviviridae, Hantaviridae, Hepadnaviridae, Hepeviridae, Nairoviridae, Nodaviridae, Orthoherpesviridae, Orthomyxoviridae, Paramyxoviridae, Parvoviridae, Phenuiviridae, Picobirnaviridae, Picornaviridae, Polyomaviridae, Poxviridae, Rhabdoviridae, Sedoreoviridae, Spinareoviridae, three unclassified been identified shrews. Diverse shrew viruses, Borna disease virus 1, Langya virus, severe fever thrombocytopenia syndrome cause diseases and/or animals, posing threats to public health animal health. This review compiled fundamental information about provided comprehensive summary the that detected aim facilitating deep understanding diversity, epidemiology, risks viruses.
Язык: Английский
Процитировано
2
Viruses, Год журнала: 2024, Номер 16(9), С. 1441 - 1441
Опубликована: Сен. 10, 2024
Shrews (Soricidae) are common small wild mammals. Some species of shrews, such as Asian house shrews (Suncus murinus), have a significant overlap in their habitats with humans and domestic animals. Currently, over 190 viruses 32 families, including Adenoviridae, Arenaviridae, Arteriviridae, Astroviridae, Anelloviridae, Bornaviridae, Caliciviridae, Chuviridae, Coronaviridae, Filoviridae, Flaviviridae, Hantaviridae, Hepadnaviridae, Hepeviridae, Nairoviridae, Nodaviridae, Orthoherpesviridae, Orthomyxoviridae, Paramyxoviridae, Parvoviridae, Phenuiviridae, Picobirnaviridae, Picornaviridae, Polyomaviridae, Poxviridae, Rhabdoviridae, Sedoreoviridae, Spinareoviridae, three unclassified been identified shrews. Diverse shrew viruses, Borna disease virus 1, Langya virus, severe fever thrombocytopenia syndrome cause diseases and/or animals, posing threats to public health animal health. This review compiled fundamental information about provided comprehensive summary the that detected aim facilitating deep understanding diversity, epidemiology, risks viruses.
Язык: Английский
Процитировано
2
International Ophthalmology Clinics, Год журнала: 2024, Номер 64(4), С. 39 - 54
Опубликована: Окт. 1, 2024
Infectious diseases may lead to ocular complications including uveitis, an inflammatory condition with potentially sight-threatening sequelae, and conjunctivitis, inflammation of the conjunctiva. Emerging infectious pathogens known findings include Ebola virus, Zika Avian influenza Nipah severe acute respiratory syndrome coronaviruses, Dengue virus. Re-emerging Toxoplasma gondii Plasmodium species that malaria. The concept One Health involves a collaborative interdisciplinary approach achieve optimal health outcomes by combining human, animal, environmental factors. This examines interconnected often complex human-pathogen-intermediate host interactions in also result disease, uveitis conjunctivitis. Through comprehensive review literature, we ophthalmic emerging diseases, pathogenesis, perspectives provide further insight into disease state. While eye care providers vision researchers focus on key local aspects process management, additional perspective host-pathogen-reservoir life cycles transmission considerations, factors, offer greater improve for affected individuals stakeholders.
Язык: Английский
Процитировано
2
Vaccines, Год журнала: 2023, Номер 12(1), С. 24 - 24
Опубликована: Дек. 25, 2023
Health emergencies caused by epidemic-prone pathogens (EPPs) have increased exponentially in recent decades. Although vaccines proven beneficial, they are unavailable for many pathogens. Furthermore, achieving timely and equitable access to against EPPs is not trivial. It requires decision-makers capture numerous interrelated factors across temporal spatial scales, with significant uncertainties, variability, delays, feedback loops that give rise dynamic unexpected behavior. Therefore, despite progress filling R&D gaps, the path licensure long-term viability of continues be unclear. This paper presents a quantitative system dynamics modeling framework evaluate sustainability vaccine supply under different vaccination strategies. Data from both literature 50 expert interviews used model demand prototypical Ebolavirus Zaire (EBOV) vaccine. Specifically, case study evaluates associated proactive ahead an outbreak similar magnitude as 2018–2020 epidemic North Kivu, Democratic Republic Congo. The scenarios presented demonstrate how uncertainties (e.g., duration vaccine-induced protection) design criteria priority geographies groups, target coverage, frequency boosters) lead important tradeoffs policy aims, public health outcomes, feasibility technical, operational, financial). With sufficient context data, provides foundation apply broad range additional ability identify leverage points preparedness offers directions further research.
Язык: Английский
Процитировано
5
Annals of Medicine and Surgery, Год журнала: 2024, Номер 86(8), С. 4579 - 4585
Опубликована: Июнь 21, 2024
Ebola virus disease (EVD) has long been a major public health concern for Democratic Republic of the Congo (DR Congo). First identified in DR 1976, country witnessed more than 25 outbreaks this deadly disease, which case fatality rate nearly 90% and manifesting with symptoms such as diarrhoea, vomiting, stomachache haemorrhagic fever. African fruit bats have speculated to be reservoir virus. is currently facing another EVD outbreak simultaneously other communicable diseases, rendering it vulnerable shortage medical paramedical staff along distrust among remote communities towards local authorities due armed conflict political instability. Moreover, lack ring vaccinations inefficient surveillance suspected individuals are some significant hurdles control. Despite availability rVSV-ZEBOV/Erbevo vaccine many antibody-based vaccines, challenges including politicization, low access communities, illiteracy limited their effectiveness. Recently, Congolese govt. put efforts building capacities at zone level, control intervention, community engagement social mobilization counter rising cases. Four successive Strategic Response Plans implemented increase resource by her partners. The Spread zoonotics can confronted implementing One Health approach, involves staff, veterinarians officials.
Язык: Английский
Процитировано
1
Recent Advances in Anti-Infective Drug Discovery, Год журнала: 2024, Номер 19(4), С. 276 - 299
Опубликована: Янв. 26, 2024
Ebola virus (EBOV) is a genus of negative-strand RNA viruses belonging to the family Filoviradae that was first described in 1976 present-day Democratic Republic Congo. It has intermittently affected substantial human populations West Africa and presents itself as global health menace due high mortality rate patients, transmission rate, difficult patient management, emergence complicated autoimmune disease-like conditions post-infection.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2024
VP40: Viral Matrix Protein 40 VSAT: Very Small Aperture Terminal in het gebied.De proef onthulde een lage seroreactiviteit voor EBOV-antigenen onder deelnemers, waarbij 1,4% reactiviteit toonde twee EBOV-Mayinga-antigenen en 8,5% GP-EBOV-Kikwit.Positieve ervaringen werden gemeld dankzij de inzet van verbetering locatie training vrijwilligers.Er echter problemen benadrukt zoals onvoldoende compensatie tijd reizen zorgen over frequente bloedafnames.Het begrip deelnemers proef, beoordeeld via scores test (TOU), significante afname loop (jaar 1 jaar 2), vooral bij degenen met minder opleiding oudere deelnemers.De uitvoering kader consortium kende verschillende uitdagingen, waaronder culturele verschillen, taalbarrières regelgevingskwesties, die duidelijke communicatie aanpassingsvermogen vereisten internationale belanghebbenden.Ondanks deze uitdagingen bereikte hoge deelnemersbehoud 92%, wat belang aanpakken deelnemerszorgen, effectieve flexibele, collaboratieve benaderingen beheer vaccinproeven afgelegen LMIC-instellingen. ConclusiesDe EBL2007-vaccinproef Gezondheidsdistrict Boende staat als belangrijke prestatie klinisch onderzoek omgevingen beperkte middelen.Het gebruik irisscantechnologie, aanvaard door 99% HCP's, illustreert effectiviteit biometrische hulpmiddelen waarborgen nauwkeurigheid integriteit proeven, opmerkelijk succespercentage 93,1% deelnemersidentificatie. Ondanks enige bezorgdheid mogelijke fysieke effecten, waargenomen visuele veranderingen, noodzaak voortdurende betrokkenheid gemeenschap communicatie.Door complexe regelgeving logistieke hindernissen te overwinnen, opmerkelijke EBOVAC 3-consortium kwaliteit, responsieve vrijwilligerstraining compensatie-en procedurele zorgen.De tijd, blijkt uit TOUscores, educatie, name opgeleide EBL2007-proef toont haalbaarheid aan opnemen diverse, sociaal-economisch achtergestelde groepen onderzoek, LMIC's, EVD-respons.Strategische planning, anticipatie op regelgevingsuitdagingen,
Процитировано
0