Psychoactive
drugs
exert
profound
effects
on
the
central
nervous
system,
influencing
behavior
and
perception.
Understanding
these
is
crucial
for
both
scientific
research
clinical
practice.
This
article
provides
an
overview
of
application
drug
discrimination
techniques
in
studying
subjective
effects,
pharmacological
mechanisms,
individual
differences,
classification
psychoactive
substances.
Through
models,
researchers
gain
insights
into
specificity
predictive
validity
substances,
particularly
hallucinogens
such
as
LSD
cannabinoids
like
THC.
The
highlights
contributions
elucidating
actions
drugs,
offering
opportunities
further
exploration
their
therapeutic
potential
abuse-related
properties.
Journal of Medical Internet Research,
Год журнала:
2024,
Номер
26, С. e59497 - e59497
Опубликована: Сен. 11, 2024
Background
Monitoring
free-living
physical
activity
(PA)
through
wearable
devices
enables
the
real-time
assessment
of
features
associated
with
health
outcomes
and
provision
treatment
recommendations
adjustments.
The
conclusions
studies
on
PA
depend
crucially
reliable
statistical
analyses
digital
data.
Data
analytics,
however,
are
challenging
due
to
various
metrics
adopted
for
measuring
PA,
different
aims
studies,
complex
temporal
variations
within
variables.
application,
interpretation,
appropriateness
these
analytical
tools
have
yet
be
summarized.
Objective
This
research
aimed
review
that
used
methods
analyzing
monitored
by
accelerometers.
Specifically,
this
addressed
three
questions:
(1)
What
describe
an
individual’s
daily
PA?
(2)
current
data,
particularly
under
classification,
association
outcomes,
prediction
events?
(3)
challenges
exist
in
analyses,
what
future
suggested
regarding
use
tasks?
Methods
scoping
was
conducted
following
existing
framework
map
exploring
information
about
PA.
Three
databases,
PubMed,
IEEE
Xplore,
ACM
Digital
Library,
were
searched
February
2024
identify
related
publications.
Eligible
articles
association,
or
involving
human
Results
After
screening
1312
articles,
428
(32.62%)
eligible
identified
categorized
into
at
least
1
3
thematic
categories:
classification
(75/428,
17.5%),
(342/428,
79.9%),
(32/428,
7.5%).
Most
(414/428,
96.7%)
derived
variables
from
3D
acceleration,
rather
than
1D
acceleration.
All
(428/428,
100%)
considered
represented
time
domain,
while
a
small
fraction
(16/428,
3.7%)
also
frequency
domain.
number
evaluating
influence
conditions
has
increased
greatly.
Among
our
review,
regression-type
models
most
prevalent
(373/428,
87.1%).
machine
learning
approach
is
gaining
popularity
(32/75,
43%).
In
addition
summary
statistics
several
recent
incorporate
trajectories
account
patterns,
including
longitudinal
data
analysis
repeated
measurements
functional
as
continuum
time-varying
(68/428,
15.9%).
Conclusions
Summary
can
quickly
provide
descriptions
strength,
frequency,
duration
individuals’
overall
When
distribution
profile
need
evaluated
detected,
considering
detailed
improve
understanding
role
plays
health.
Depending
goal,
appropriate
ensure
reliability
scientific
findings.
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Май 28, 2024
Introduction
Sleeping
disorders
is
a
high
prevalent
disorder,
and
although
previous
research
has
suggested
link
between
smoking
sleep
disorders,
there
lack
of
large-scale,
nationally
representative
studies
examining
this
association
across
multiple
outcomes
exploring
dose-response
relationships.
Methods
This
study
used
data
from
30,269
participants
the
NHANES
database
(2007–2020).
Weighted
logistic
regression
models
were
to
assess
associations
status
(non-smoker,
light
smoker,
moderate
heavy
smoker)
various
outcomes,
including
insufficient
duration,
reported
problems,
snoring,
snorting,
or
stopping
breathing
during
sleep,
daytime
sleepiness.
Dose-response
relationships
explored
using
restricted
cubic
splines.
Results
Compared
non-smokers,
smokers
had
significantly
higher
odds
experiencing
duration
with
OR
1.732
(95%
CI
1.528–1.963,
P
<0.001),
problems
1.990
1.766–2.243,
occasional
frequent
snoring
1.908
1.164–3.128,
=
0.03),
snorting
1.863
1.183–2.936,
0.022),
while
results
for
sometimes,
often
almost
always
being
overly
sleepy
day
1.257
0.872–1.810,
0.115)
are
not
significant.
A
trend
positive
correlation
was
observed
all
disorder
(P
<
0.05).
analyses
revealed
that
these
increased
levels.
Conclusion
Smoking
associated
relationship
exists
levels
problems.
These
findings
underscore
importance
addressing
as
modifiable
risk
factor
poor
health
suggest
reducing
smoking,
even
if
complete
cessation
achieved,
may
have
effects
on
outcomes.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 26, 2024
The
prevalence
of
diabetes
mellitus
(DM)
is
a
significant
public
health
concern,
especially
among
individuals
with
short
sleep
duration.
Understanding
the
relationship
between
physical
exercise
and
DM
in
this
population
crucial
for
developing
effective
prevention
strategies.
However,
presence
potential
threshold
effect
on
risk
remains
unclear.
Objective:
This
study
investigates
the
development
trends
and
research
hotspots
in
clinical
testing
for
multiple
myeloma
from
2000
to
2023,
using
bibliometric
techniques.
Method:
Search
relevant
literature
on
of
published
Web
Science
Core
Collection
(WoSCC)
use
CiteSpace
6.2.R4
software
draw
a
visual
knowledge
map
authors,
institutions,
national
regional
cooperation
networks,
journals,
keywords,
conduct
analysis.
Results:
The
found
an
upward
trend
publications
over
specified
period,
with
significant
growth
noted
2012
onwards.
majority
originates
United
States,
contributions
institutions
like
Mayo
Clinic
MD
Anderson
Cancer
Center.
Analysis
author
collaboration
networks
indicated
relatively
low
centrality,
suggesting
minimal
among
researchers.
Bibliometric
mapping
highlighted
several
field
including
therapeutic
strategies
involving
proteasome
inhibitors
immunomodulatory
drugs,
role
stem
cell
transplantation,
importance
achieving
monitoring
residual
disease.
Conclusion:
is
characterized
by
growing
body
research,
States.
Despite
increasing
volume
there
need
enhanced
researchers
consolidate
findings
advance
practice.
Biological Research For Nursing,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Purpose:
To
examine
the
association
between
trajectories
of
physical
activity
(PA)
over
12
years
and
epigenetic
age
acceleration
(EAA)
in
3600
middle-aged
older
adults
Health
Retirement
Study.
Methods:
Latent
variable
mixture
modeling
identified
subgroups
with
similar
vigorous,
moderate,
light
PA
from
2004
to
2016.
Six
EAAs,
including
Horvath’s
acceleration,
Hannum’s
GrimAge
PhenoAge
DunedinPoAm
ZhangAA
were
calculated
by
regressing
on
chronological
Linear
regression
models
tested
associations
controlling
for
age,
sex,
race,
education,
smoking,
alcohol
consumption,
depression.
Results:
Five
each
type.
Moderate
stable
or
slightly
changed
time.
In
contrast,
vigorous
either
consistently
low
(27.2%),
increased
at
a
level
(14.9%),
decreased
moderate
levels
(25.9%),
high
(11.9%),
(20.1%).
negatively
associated
EAA
across
six
clocks
(
p
<
.01).
Light
not
any
EAA.
Vigorous
slower
=
.004)
.03).
Participants
that
showed
increasing
had
compared
those
PA.
Conclusion:
but
light,
EAAs.
This
study
aimed
to
delineate
the
evolving
knowledge
structure
of
programmed
cell
death
in
esophageal
cancer
and
identify
key
thematic
trends,
influential
collaborations,
emerging
areas
for
future
research.
A
bibliometric
approach
was
applied
2677
publications
retrieved
from
Web
Science
Core
Collection
(2000-2024).
Three
complementary
tools-CiteSpace,
VOSviewer,
bibliometrix-were
employed
visualize
co-citation
networks,
detect
citation
bursts,
map
collaborative
patterns
among
authors,
institutions,
countries.
Inclusion
criteria
focused
on
articles
reviews
that
addressed
conjunction
with
apoptosis,
necroptosis,
pyroptosis,
ferroptosis,
autophagy,
or
related
pathways.
Publication
outputs
grew
markedly,
reflecting
a
shift
early
investigations
basic
apoptotic
mechanisms
broader
explorations
ferroptosis.
China
led
publication
volume
citations,
driven
by
substantial
governmental
funding
large
clinical
cohorts.
The
United
States
Japan
also
contributed
significantly,
forming
international
research
networks
spanned
Asia
Europe.
Leading
particularly
Zhengzhou
University,
demonstrated
extensive
collaborations.
Journals
such
as
Oncology
Letters
Reports
were
prominent
outlets
new
findings,
while
highly
cited
references
highlighted
hypoxia,
immune
checkpoint
blockade,
gene-editing
strategies.
Keyword
analyses
revealed
ascendance
immuno-oncology,
network
pharmacology,
translational
applications
targeting
multiple
regulated
Bibliometric
evidence
underscores
rapid
expansion
multidisciplinary
integrates
diverse
pathways
cancer.
Continued
leveraging
advanced
genomics
immunologic
strategies,
are
poised
accelerate
breakthroughs
enable
more
personalized,
effective
therapies.
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 6293 - 6304
Опубликована: Май 1, 2025
To
investigate
the
relationship
between
phenotypic
age
(PhenoAge)
and
accelerated
(PhenoAgeAccel)
recurrence
of
atrial
fibrillation
(AF)
in
patients
after
radiofrequency
catheter
ablation
(RFCA).
Preoperative
PhenoAge
PhenoAgeAccel
were
determined
AF
undergoing
RFCA.
We
used
logistic
regression
models
subgroup
analysis
to
study
risk
recurrence.
As
for
revealing
value
predicting
recurrence,
ROC
curve
was
performed.
further
detect
enhancement
role
APPLE
score
a
model
established
factors
C-statistics,
net
reclassification
improvement
(NRI),
integrated
discrimination
(IDI)
conducted.
A
total
322
with
who
underwent
RFCA
our
hospital
included
present
study.
The
mean
follow-up
period
21
months.
frequency
increased
gradually
as
index
rose.
optimal
cut-off
-0.338.
Patients
≥
-0.338
had
significantly
greater
likelihood
experiencing
recurrent
than
those
<-0.338
(OR
3.989,
95%
CI
2.006-7.933,
p
<
0.001).
association
also
reflected
each
subgroup.
Incorporating
into
existing
may
result
enhancements
NRI
IDI
(p<0.05),
respectively.
positively
independently
associated
following
This
bibliometric
study
aimed
to
elucidate
key
developments,
influential
publications,
and
emerging
research
hotspots
on
programmed
cell
death
(PCD)
in
liver
cancer-associated
pain,
thereby
providing
guidance
for
future
mechanism-based,
patient-centered
therapies.
A
comprehensive
search
was
performed
the
Web
of
Science
using
terms
encompassing
cancer,
various
PCD
modalities.
After
multi-stage
screening
relevance
quality,
a
dataset
324
articles
(2000-2024)
analyzed.
Tools
such
as
VOSviewer
Bibliometrix
facilitated
performance
analysis,
co-citation
mapping,
keyword
clustering,
trend
topic
identification.
The
annual
publication
output
increased
notably
after
2015,
reflecting
intensified
interest
molecular
pathways
(apoptosis,
ferroptosis,
autophagy)
their
clinical
implications.
China
led
volume,
while
USA
several
European
countries
demonstrated
high
impact
extensive
international
collaborations.
Keyword
analysis
revealed
five
thematic
clusters,
highlighting
prominence
inflammation,
NF-κB
signaling,
oxidative
stress-mediated
apoptosis,
combined
therapeutic
approaches,
metastasis-driven
pain.
Highly
cited
focused
flavonoids
immunogenic
death,
cyclooxygenase-2
regulation,
underscoring
shift
toward
integrative
regimens
that
target
both
tumor
progression
pain
mechanisms.
Programmed
cancer
has
evolved
into
rapidly
expanding,
multidisciplinary
field.
Findings
point
paradigm
from
purely
cytotoxic
strategies
more
holistic
approaches
merge
immunotherapy,
biomarker-driven
diagnosis,
targeted
interventions
at
alleviating
controlling
growth.
These
insights
lay
groundwork
precision-oriented,
mechanism-based
treatments
address
multifaceted
challenges
faced
by
patients
with
advanced
cancer.
