Identification and validation of PANoptosis-related LncRNAs prognosis system in hepatocellular carcinoma
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 19, 2025
Abstract
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
common
solid
malignancies
in
world.
Due
to
limited
effectiveness
current
drug
treatments,
further
research
on
HCC
necessary.
PANoptosis
defined
as
an
inflammatory
RCD
whose
main
features
combine
pyroptosis,
apoptosis
and
necroptosis
which
cannot
be
explained
by
any
these
three
RCDs
alone.
In
HCC,
risk
stratification
based
PANoptosis-associated
lncRNAs
has
clinical
application
potential.
this
study,
we
explored
related
PANoptosis-related
(PRLs)
analyzing
significantly
differentially
expressed
genes
HCC.
HCC-associated
PRL
scores
were
established
WGCNA,
LASSO
analysis
multivariate
Cox
assessment.
Subsequently,
verified
prognostic
ability
score
for
patients,
basis
a
assessment
model
its
reliability.
The
relationship
between
immune
infiltration
well
sensitivity
was
analyzed
evaluate
reference
value
model.
Western
blot
PCR
reliability
bioinformatics
results.
observed
suppression
progression
invasiveness
following
selected
knockdown
validated
our
Our
results
provide
new
evidence
role
Язык: Английский
Hot and Cold Fibrosis: The Role of Serum Biomarkers to assess the Immune Mechanisms and ECM-Cell Interactions in Human Fibrosis
Journal of Hepatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Fibrosis
is
a
pathological
condition
characterized
by
excessive
accumulation
of
extracellular
matrix
(ECM)
components,
particularly
collagens,
leading
to
tissue
scarring
and
organ
dysfunction.
In
fibrosis,
an
imbalance
between
collagen
synthesis
(fibrogenesis)
degradation
(fibrolysis)
results
in
the
deposition
fibrillar
collagens
disrupting
structural
integrity
ECM
and,
consequently,
architecture.
associated
with
wide
range
chronic
diseases,
including
liver
cirrhosis,
kidney
pulmonary
autoimmune
diseases.
Recently,
concept
"hot"
"cold"
fibrosis
has
emerged,
referring
immune
status
within
fibrotic
tissues
nature
fibrogenic
signaling.
Hot
active
cell
infiltration
inflammation,
while
cold
auto-
paracrine
myofibroblast
activation,
exclusion
quiescence.
This
article
aims
explore
relationship
hot
role
various
types
their
biologically
fragments
modulating
system,
how
serological
biomarkers
can
help
understanding
disease-relevant
interactions
mesenchymal
cells
tissues.
Additionally,
we
draw
lessons
from
immuno-oncology
research
solid
tumors
shed
light
on
potential
strategies
for
treatment
highlight
advantage
having
"hot
environment"
treat
enhancing
through
modulation
system.
Язык: Английский
Prognosis prediction of head and neck squamous cell carcinoma through the basement membrane-related lncRNA risk model
Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 23, 2024
Background
Head
and
neck
squamous
cell
carcinoma
(HNSCC)
ranks
among
the
most
widespread
significantly
heterogeneous
malignant
tumors
globally.
Increasing
evidence
suggests
that
basement
membrane
(BM)
associated
long
non-coding
RNAs
(lncRNA)
are
correlated
with
onset
of
HNSCC
its
prognosis.
Our
study
aims
to
construct
a
membrane-associated
lncRNAs
(BMlncRNAs)
marker
accurately
predict
prognosis
patients
find
novel
immunotherapy
targets.
Methods
The
Cancer
Genome
Atlas
(TCGA)
database
was
accessed
acquire
transcriptome
expression
matrices,
somatic
mutation
data,
clinical
follow-up
data
patients.
Utilizing
co-expression
analysis,
BMlncRNAs
were
identified
differentially
expressed
(DEBMlncRNA)
then
filtered,
filtering
thresholds
FDR<0.05
|log2FC|≥1.
Furthermore,
univariate
least
absolute
shrinkage
selection
operator
(LASSO),
multivariable
Cox
regression
utilized
develop
risk
model.
model
underwent
thorough
evaluation
across
diverse
perspectives,
encompassing
tumor
immune
infiltration,
burden
(TMB),
functional
enrichment,
chemotherapy
sensitivity.
Results
assessment
consists
14
BMlncRNA
pairs.
acquired
is
indicative
reliability
score
in
capacity
as
prognostic
factor.
Individuals
at
high
exhibited
poorer
prognosis,
statistically
significant
variance
noted
TMB
infiltration
compared
low-risk
group.
Additionally,
heightened
sensitivity
paclitaxel
docetaxel
evident
risk.
Conclusion
We
have
established
BMLncRNA-based
can
provide
guidance
for
future
laboratory
studies
HNSCC.
Язык: Английский
Identification and Validation of Basement Membrane Related LncRNA Signatures as a Novel Prognostic Model for Hepatocellular Carcinoma
Biochemical Genetics,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 29, 2024
Abstract
Hepatocellular
carcinoma
(HCC)
is
a
significant
cancer
with
limited
treatments
and
poor
prognosis,
the
basement
membrane
(BM)
playing
crucial
role
in
its
initiation
growth.
This
study
utilized
data
from
The
Cancer
Genome
Atlas
Gene
Expression
Omnibus
(GEO)
databases
to
identify
membrane-related
genes
differentially
expressed
HCC.
Through
gene
co-expression
analysis,
BM-associated
long
non-coding
RNAs
(lncRNAs)
were
discovered.
LncRNAs
related
HCC
survival
selected
via
univariate
prognostic
model
was
constructed
using
LASSO
regression
multivariate
analysis.
effectively
classified
patients
into
high
low-risk
groups,
uncovering
differences
immune
response,
mutation,
drug
sensitivity.
Six
BM-related
lncRNAs
(GSEC,
MIR4435-2HG,
AC092614.1,
AC127521.1,
LINC02580,
AC008050.1)
validated
normal
cell
lines,
key
of
AC092614.1
regulating
proliferation,
migration,
invasion
cells
vitro
explored.
research
emphasizes
therapeutic
relevance
HCC,
highlighting
AC092614.1’s
disease
progression
as
potential
target
for
targeted
therapy.
Язык: Английский