Heliyon, Год журнала: 2024, Номер 10(19), С. e38290 - e38290
Опубликована: Сен. 23, 2024
Язык: Английский
Biomaterials Research, Год журнала: 2024, Номер 28
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
7
Current Pharmaceutical Design, Год журнала: 2024, Номер 31(4), С. 244 - 260
Опубликована: Апрель 30, 2024
In recent years, advancements in chemistry have allowed the tailoring of materials at nanoscopic level as needed. There are mainly four main types nanomaterials used drug carriers:metal-based nanomaterials, organic inorganic and polymer nanomaterials. The a carrier showed advantages for decreased side effects with higher therapeutic index. stability compounds increased by encapsulation within nano-drug carriers, leading to systemic toxicity. Nano-drug carriers also controlled release system-made solubility characteristics nanoparticles surface coating surfactants. review focuses on different nanoparticle synthesis process, techniques purposes, applications prospects biomedical applications.
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 6, 2025
In this work, we synthesize a quinoline-based heptamethine cyanine, QuCy7, with sulfonate groups to enhance water solubility. This dye demonstrates exceptional near-infrared absorption beyond 750 nm, accompanied by photothermal properties but low photostability. Encapsulating QyCy7 polyethylene glycol form nanopolymer, QuCy7@mPEG NPs, addresses the issue of its photoinstability. TEM showed that NPs possess spherical morphology, featuring core-shell structure size around 120 nm in diameter. Upon irradiation an 808 laser for 10 min, significant increase temperature up 24 °C can be achieved conversion (PTC) rate approximately 35%. exhibit remarkable stability as compared QuCy7. The efficiency was demonstrated vitro PTT studies. Finally, nanoparticles' acute toxicity and effectiveness were assessed using chick embryo model. results provide compelling evidence are safe without inducing hemolysis, inhibit angiogenesis when exposed light, anti-tumor activity 76% reduction tumor QuCy7 (40%). Thus suggesting solubility, nanopolymer is biocompatible possesses superior efficacy.
Язык: Английский
Процитировано
0
Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104646 - 104646
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Pharmaceuticals, Год журнала: 2025, Номер 18(2), С. 257 - 257
Опубликована: Фев. 14, 2025
Colon cancer remains a significant global health challenge; however, the treatment outcome for colon patients can be improved through early detection and effective treatment. Nano-radiopharmaceuticals, combining nanotechnology with radiopharmaceuticals, are emerging as revolutionary approach in both diagnostic imaging therapy, playing role management of patients. This review examines use nano-radiopharmaceuticals diagnosis cancer, highlighting current applications, challenges, future directions. Nanocarriers radionuclides have shown potential improving treatment, including liposomes, microparticles, nanoparticles, micelles, dendrimers, hydrogels, which approved by FDA. These nanocarriers deliver targeted drugs into malignant cells without affecting normal cells, reducing side effects. Antibody-guided systemic radionuclide-targeted therapy has treating cancer. Novel nanomedicines, like Hensify 32P BioSilicon, under clinical development radiation delivery percutaneous intratumoral injections. Although using is superior technique diagnosing there limitations such unintentional accumulation nanoparticles healthy tissues, leads to toxicity due biodistribution issues, well high manufacturing costs that limit their availability However, direction moving toward providing more precise crucial enhancing production costs.
Язык: Английский
Процитировано
0
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 243, С. 114125 - 114125
Опубликована: Июль 26, 2024
Язык: Английский
Процитировано
3
Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 15
Опубликована: Май 6, 2025
Gold nanoparticles (AuNPs) possess unique properties, including low toxicity and excellent optical characteristics, making them highly appealing for biomedical applications. The plasmonic photothermal effect of AuNPs has been explored to trigger localized hyperthermia. Four commonly gold (spheres, rods, stars, cages) are produced optimized present the surface plasmon resonance in near-infrared region, exploiting increased penetration human body. Additionally, production hybrid AuNPs, combining with other materials, such as silica, graphene, zinc oxide, polymers, small molecules amplify (T ≥ 45ºC). This review provides an overview AuNPs' application therapy, describing general synthesis processes main particle parameters that affect their nanomaterials. Associated this rapid progress, functionalization can also improve colloidal stability, safety, therapeutic outcomes. In regard, we highlight emerging trend applying cell-derived vesicles biomimetic coatings, capable evading immune recognition, increasing blood circulation, targeting specific tissues. addition, challenges future developments accelerating clinical translations discussed light theragnostic potential.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 103, С. 106429 - 106429
Опубликована: Ноя. 22, 2024
Язык: Английский
Процитировано
1
Heliyon, Год журнала: 2024, Номер 10(3), С. e25289 - e25289
Опубликована: Янв. 26, 2024
The present investigation aims to design and development of hybrid zinc oxide (ZnO) manganese dioxide (MnO2) nanoparticles (NPs) doped-biopolymer matrix-based cost-effective technique for the synthesis biocompatible Kaolinite/Chitosan (Ka/CS) nanocomposites (NCs) could be used as agents wound healing due their efficiency low toxicity. crystallite size, phase purity surface morphology synthesised NCs were investigated systemic analytical methods. results revealed that metal presented in rod-crystalline shape additionally exhibits 20–30 nm size. In vitro antibacterial analyses demonstrates have significantly improved bactericidal inhibition when compared bare NPs polymeric components. biocompatibility observation prepared hybrid-NPs encapsulated enhanced cell survival rate (>90 %), which was established by MTT assay Live/Dead fluorescence methods at different incubation time. DPPH investigate synergistic effects dressing materials increased antioxidant activity. Preliminary research indicates these nanocomposites, ZnO/MnO2 incorporated decorated with Ka/CS NCs, a significant promoter potential candidate use robust agent post-operative nursing care.
Язык: Английский
Процитировано
1
Journal of Composites Science, Год журнала: 2024, Номер 8(11), С. 460 - 460
Опубликована: Ноя. 7, 2024
Cancer remains one of the most critical global health issues. Conventional treatments, such as radiotherapy, surgery, or chemotherapy, have limitations, especially concerning side effects, resistance, and recurrence. Consequently, new innovative treatments to overcome these problems are needed. Photothermal therapy (PTT) is a promising alternative that uses photothermal agents convert near-infrared light (NIR) into heat kill cancer cells. Nanoparticles can be used also drug delivery platforms, improving drugs’ stability, allowing for targeted delivery, reducing toxicity. Due its broad absorption band, high surface area, versatility functionalization, tungsten disulfide (WS2) has potential in this context. This paper presents state-of-the-art on use WS2-based materials achieve effective biocompatible anticancer treatment strategies.
Язык: Английский
Процитировано
1