Improved biocompatibility and osteogenesis of porous graphene oxide/silk fibroin scaffold for potential applications in bone tissue engineering

Materials Today Communications, Год журнала: 2024, Номер 40, С. 109480 - 109480

Опубликована: Июнь 13, 2024

Язык: Английский

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3D Printing and Electrospinning of Drug- and Graphene-Enhanced Polycaprolactone Scaffolds for Osteochondral Nasal Repair

Materials, Год журнала: 2025, Номер 18(8), С. 1826 - 1826

Опубликована: Апрель 16, 2025

A novel bi-layered scaffold, obtained via 3D printing and electrospinning, was designed to improve osteochondral region reconstruction. The upper electrospun membrane will act as a barrier against unwanted tissue infiltration, while the lower 3D-printed layer provide porous structure for ingrowth. Graphene integrated into scaffold its antibacterial properties, drug Osteogenon® (OST) added promote bone regeneration. composite scaffolds were subjected comprehensive physical, thermal, mechanical evaluations. Additionally, their biological functionality assessed by means of NHAC-kn cells. 0.5% graphene addition PCL significantly increased strain at break, enhancing material ductility. GNP also acted an effective nucleating agent, raising crystallization temperatures supporting mineralization. high surface area facilitated rapid apatite formation attracting calcium phosphate ions. This confirmed FTIR, µCT SEM analyses, which highlighted positive impact on mineral deposition. synergistic interaction between nanoplatelets created bioactive environment that enhanced cell adhesion proliferation, promoted superior formation. These findings highlight scaffold’s potential promising biomaterial repair regenerative medicine.

Язык: Английский

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An integrated design strategy coupling Additive Manufacturing and Matrix-Assisted Pulsed Laser Evaporation (MAPLE) towards the development of a new concept 3D scaffold with improved properties for Tissue Regeneration

Nanoscale Advances, Год журнала: 2024, Номер 6(12), С. 3064 - 3072

Опубликована: Янв. 1, 2024

New concept 3D scaffolds coated with a biocompatible graphene material (GL) obtained by combining additive manufacturing (AM) and matrix-assisted pulsed laser evaporation (MAPLE) deposition are potential candidates for bone tissue engineering.

Язык: Английский

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Microstructure and Biocompatibility of Graphene Oxide/BCZT Composite Ceramics via Fast Hot-Pressed Sintering

Coatings, Год журнала: 2024, Номер 14(6), С. 689 - 689

Опубликована: Июнь 1, 2024

Improving fracture toughness, electrical conductivity, and biocompatibility has consistently presented challenges in the development of artificial bone replacement materials. This paper presents a new strategy for creating high-performance, multifunctional composite ceramic materials by doping graphene oxide (GO), which is known to induce osteoblast differentiation enhance cell adhesion proliferation into barium calcium zirconate titanate (BCZT) ceramics that already exhibit good mechanical properties, piezoelectric effects, low cytotoxicity. Using fast hot-pressed sintering under vacuum conditions, (1 − x)(Ba0.85Ca0.15Zr0.1Ti0.9)O3−xGO (0.2 mol% ≤ x 0.5 mol%) were successfully synthesized. Experimental results revealed these exhibited high properties (d33 = 18 pC/N, kp 62%) microhardness (173.76 HV0.5), meeting standards substitutes. Furthermore, incorporation significantly reduced water contact angle enhanced their wettability. Cell viability tests using Counting Kit-8, alkaline phosphatase staining, DAPI staining demonstrated GO/BCZT non-cytotoxic effectively promoted growth, indicating excellent biocompatibility. Consequently, with superior performance, biocompatibility, show extensive potential application defect repair.

Язык: Английский

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Development of an active agar aerogel with dual antioxidant and UV-blocking activities using chlorine-doped graphene quantum dots

Heliyon, Год журнала: 2024, Номер 10(14), С. e34387 - e34387

Опубликована: Июль 1, 2024

Active packaging is of great interest in the modern food industry due to increasing shelf life and enhancing quality. The importance this technology increases when natural polymers are used construction active packages. Development a natural, biodegradable, dual-active film was aimed study. So, agar aerogel containing different amounts chlorine-doped graphene quantum dots (Cl-GQDs) prepared. Cl-GQDs had excitation-dependent fluorimetry behavior zigzag edges graphene. mean diameter spherical nanoparticles about 12 nm, according HR-TEM images. results Raman ATR-FTIR confirmed that chlorine well-doped on GQD structure. showed high UV-absorption capability very strong antioxidant activity (94.31 %), which maintained these activities after incorporation into aerogel. doped responsible for capacity charge transfer GQDs. BET SEM adding caused porous Finally, types aerogels can be considering intended application Agar 20 % suggested if with good thermal insulation properties considered. However, 1 suitable as an film. In conclusion, while hold promise sustainable multifunctional materials, their potential toxic effects must thoroughly evaluated. Future studies should explore migration, interactions specific matrices, long-term safety ensure consumer protection.

Язык: Английский

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Graphene Derivatives Functionalized Polycaprolactone/Gelatin Electrospun Nanofibrous Membrane Through Mussel-Inspired Polydopamine: Multifunctional Scaffold with High Potential for Nerve Tissue Engineering

Journal of Polymers and the Environment, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Язык: Английский

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Biomolecule-functionalized exfoliated-graphene and graphene oxide as heteronucleants of nanocrystalline apatites to make hybrid nanocomposites with tailored mechanical, luminescent, and biological properties

Ceramics International, Год журнала: 2024, Номер 50(23), С. 51192 - 51206

Опубликована: Окт. 8, 2024

Язык: Английский

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Reduced Graphene Oxide-Substituted Nanohydroxyapatite: Rejuvenating Bone–Nerve Crosstalk with Electrical Cues in a Fragility Fracture Rat Model under Hyperglycemia

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(44), С. 59738 - 59751

Опубликована: Окт. 28, 2024

Diabetes has currently acquired the status of epidemic worldwide, and among its various pathological consequences like retinopathy nephropathy, bone fragility fractures from diabetic osteopathy occurs in later stages is equally destructive. Chronic hyperglycemia culminates into deteriorating microvasculature quality bone, making it prone to fractures. Among these, hip are most common, especially older patients apart underlying neuropathy. Our study an attempt ameliorate fracture nerve trauma with electrical stimulation as interface a chronic rat model. We have fabricated reduced graphene oxide-substituted hydroxyapatite electroactive substitute incorporated chitosan gelatin cryogels. The situ reduction oxide during sintering imparts higher potential composite dealing problem at question. cryogels depicted optimum vitro biocompatibility enhanced mineralization after ectopic subcutaneous implantation rats. therapeutic potency was evaluated model compression sciatic rats, mimicking severe clinical trauma. presence femoral neck canal coupled biochemical factors significantly improved regeneration rats microcomputed tomography analysis histology images. application also ameliorated observed 70% improvement electrophysiological parameters such compound muscle action combinatorial therapy. therefore report successful implication multitarget therapy unraveling bone-nerve crosstalk smart

Язык: Английский

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Functionalization of 3D printed poly(lactic acid)/graphene oxide/β-tricalcium phosphate (PLA/GO/TCP) scaffolds for bone tissue regeneration application

RSC Advances, Год журнала: 2024, Номер 14(54), С. 39804 - 39819

Опубликована: Янв. 1, 2024

3D printing of PLA/GO/TCP scaffolds and surface functionalization polymeric with POLYL.

Язык: Английский

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Engineered Nanomaterials for Biomedicine: Surface Modification Strategies

Опубликована: Дек. 9, 2024

Язык: Английский

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