Collagen peptides alleviate hyperglycemia in mice by modulating insulin resistance, glucose metabolism and gut microbiota
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
301, С. 140498 - 140498
Опубликована: Янв. 29, 2025
Язык: Английский
Acer tegmeutosum Maxim extract alleviates acute alcohol-induced liver disease and regulates gut microbiota dysbiosis in mice
Archives of Biochemistry and Biophysics,
Год журнала:
2025,
Номер
unknown, С. 110314 - 110314
Опубликована: Янв. 1, 2025
Язык: Английский
A Multidisciplinary Approach of Type 1 Diabetes: The Intersection of Technology, Immunotherapy, and Personalized Medicine
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2144 - 2144
Опубликована: Март 21, 2025
Background:
Type
1
diabetes
(T1D)
is
a
chronic
autoimmune
disorder
characterized
by
the
destruction
of
pancreatic
β-cells,
leading
to
absolute
insulin
deficiency.
Despite
advancements
in
therapy
and
glucose
monitoring,
achieving
optimal
glycemic
control
remains
challenge.
Emerging
technologies
novel
therapeutic
strategies
are
transforming
landscape
T1D
management,
offering
new
opportunities
for
improved
outcomes.
Methods:
This
review
synthesizes
recent
treatment,
focusing
on
innovations
continuous
monitoring
(CGM),
automated
delivery
systems,
smart
formulations,
telemedicine,
artificial
intelligence
(AI).
Additionally,
we
explore
biomedical
approaches
such
as
stem
cell
therapy,
gene
editing,
immunotherapy,
gut
microbiota
modulation,
nanomedicine-based
interventions,
trace
element-based
therapies.
Results:
Advances
digital
health,
including
CGM
integration
with
hybrid
closed-loop
pumps
AI-driven
predictive
analytics,
have
significantly
real-time
management.
AI
telemedicine
enhanced
personalized
care
patient
engagement.
Furthermore,
regenerative
medicine
strategies,
β-cell
replacement,
CRISPR-based
immunomodulatory
therapies,
hold
potential
disease
modification.
Probiotics
microbiome-targeted
therapies
demonstrated
promising
effects
maintaining
metabolic
homeostasis,
while
elements
provide
additional
regulate
sensitivity
oxidative
stress.
Conclusions:
The
future
management
shifting
toward
precision
integrated
technological
solutions.
While
these
present
avenues,
challenges
long-term
efficacy,
safety,
accessibility,
clinical
validation
must
be
addressed.
A
multidisciplinary
approach,
combining
research,
intelligence,
nanotechnology,
will
essential
translate
into
practice,
ultimately
improving
quality
life
individuals
T1D.
Язык: Английский
Porous starch microspheres loaded with luteolin exhibit hypoglycemic activities and alter gut microbial communities in type 2 diabetes mellitus mice
Food & Function,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 8, 2024
PSLUT
exhibit
hypoglycemic
activities
and
alter
gut
microbial
communities
in
type
2
diabetes
mellitus
mice.
Язык: Английский
Unveiling the World of Bioinformatics
Khushboo Dhiman,
Hardik Dhiman
Advances in bioinformatics and biomedical engineering book series,
Год журнала:
2024,
Номер
unknown, С. 181 - 200
Опубликована: Март 22, 2024
This
chapter
take
a
fascinating
voyage
across
the
complex
bioinformatics
landscapes.
The
authors
begin
by
defining
as
essential
connection
that
connects
unprocessed
biological
data
to
useful
knowledge,
laying
groundwork
for
an
investigation
into
core
fields
of
proteomics,
genomics,
and
mining.
story
flows
naturally,
showing
how
feature
refinement
techniques,
machine
learning's
predictive
power,
deep
revolutionary
ability
understand
intricate
processes
all
work
together
in
harmony.
Applications
real
world
emerge,
demonstrating
palpable
effects
on
drug
discovery,
prediction
protein
functionality,
rapidly
expanding
field
personalised
medicine.
But
this
journey
is
not
without
its
difficulties;
we
must
negotiate
nuances
integration,
contend
with
interpretability
learning
models,
fight
moral
dilemmas,
face
computing
demands
big
data.
Every
obstacle
turns
doorway
creativity.
Язык: Английский
Identification and Validation of Vascular-Associated Biomarkers for the Prognosis and Potential Pathogenesis of Hypertension Using Comprehensive Bioinformatics Methods
World Journal of Cardiovascular Diseases,
Год журнала:
2024,
Номер
14(03), С. 115 - 128
Опубликована: Янв. 1, 2024
Background:
Hypertension,
also
known
as
increased
blood
pressure,
is
a
phenomenon
in
which
flows
vessels
and
causes
persistently
higher-than-normal
pressure
on
the
vessel
wall.
The
identification
of
novel
prognostic
pathogenesis
biomarkers
plays
key
role
management
hypertension.
Methods:
GSE7483
GSE75815
datasets
from
gene
expression
omnibus
(GEO)
database
were
used
to
identify
genes
associated
with
hypertension
that
differentially
expressed
(DEGs).
functional
DEGs
was
elucidated
by
body
(GO)
enrichment
analysis.
In
addition,
we
performed
an
immune
infiltration
assay
GSEA
hypertensive
patients
verified
RT-qPCR.
Results:
A
total
267
identified
GEO
database.
GO
analysis
revealed
these
mainly
biological
processes
such
fibroblast
proliferation,
cell
structural
organization,
extracellular
matrix
vasculature
development
regulation,
angiogenesis.
We
five
possible
biomarkers,
Ecm1,
Sparc,
Sphk1,
Thbsl,
Mecp2,
correlate
vascular
angiogenesis
characteristic
bioinformatics,
explored
clinical
levels
RT-qPCR,
found
Thbs1
showed
significant
up-regulation,
agreement
results
bioinformatics
Conclusion:
Our
study
suggested
Sphk1
may
be
potential
for
diagnosis,
treatment
prognosis
they
are
involved
regulation
Язык: Английский