A review of recent developments in pharmaceutical chemistry on biological evolution of tetrazole derivatives DOI Creative Commons

Zahraa A. Ketan,

Halah A. R. Ibrahim,

Dhuha K. Slma

и другие.

Al-Salam Journal for Medical Science, Год журнала: 2024, Номер 4(1), С. 1 - 8

Опубликована: Авг. 11, 2024

This review sums up the developments in biological activity of tetrazole active derivatives recent days. Some deliberated are at present actively scientifically studied; some them have that enables to be studied further future as a drug for various activities. seeks offer comprehensive analysis efficacy and clinical advantage derivatives.

Язык: Английский

Cheminformatics-based design and biomedical applications of a new Hydroxyphenylcalix[4] resorcinarene as anti-cancer agent DOI Creative Commons
Solhe F. Alshahateet, Rakan M. Altarawneh, Salah A. Al‐Trawneh

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 13, 2024

Abstract The distinct conformational characteristics, functionality, affordability, low toxicity, and usefulness make calixarene-based compounds a promising treatment option for cancer. aim of the present study is to synthesize new compound assess its anticancer potential on some human cancer cells. synthesized C-4-Hydroxyphenylcalix[4] resorcinarene ( HPCR ) was characterized by several spectroscopic techniques such as 1HNMR, 13CNMR, X-ray crystallographic analysis confirm purity identity. IC 50 values were identified cell lines (U-87, MCF-7, A549) dermal fibroblasts line (HDF) after with standard drug Cisplatin. A significant selective growth inhibitory activity against U-87 A549 obtained at an concentration 100 μM. MOE docking module (version 2015) utilized extent inhibition four cancer-related proteins (3RJ3, 7AXD, 6DUK, 1CGL).

Язык: Английский

Процитировано

1
The current landscape of 1,2,3‐triazole‐(fused) six‐membered nitrogen‐containing heteroaromatic ring hybrids with anticancer therapeutic potential DOI Open Access

Zhi Xu,

Rongqiang Li,

Zhiwei Huang

и другие.

Archiv der Pharmazie, Год журнала: 2024, Номер 358(1)

Опубликована: Дек. 30, 2024

Cancer, characterized by uncontrolled growth and spread of abnormal cells potentially influencing almost all tissues in the body, is one most devastating lethal diseases throughout world. Chemotherapy principal approaches for cancer treatment, but multidrug resistance severe side effects represent main barriers to success therapy, creating a vital need develop novel chemotherapeutic agents. The 1,2,3-triazole moiety can be conveniently constructed "click chemistry" could exert diverse noncovalent interactions with various enzymes cells. Hence, fascinating anticancer pharmacophores. Moreover, also serve as powerful ligation tool complex molecular architectures increase efficacy lead molecules. Notably, 1,2,3-triazole-containing hybrids intriguing structural variations target different biological components simultaneously, highlighting their potential treatment eradication cancer. This review outlines current landscape 1,2,3-triazole-(fused) six-membered nitrogen-containing heteroaromatic ring hybrids, inclusive 1,2,3-triazole-quinazolines, 1,2,3-triazole-quinazolinones, 1,2,3-triazole-quinolines, 1,2,3-triazole-quinolones, 1,2,3-triazole-pyridines, 1,2,3-triazole-pyrimidines, therapeutic potential, explores mechanisms action, critical aspects design well structure-activity relationships (SARs), covering articles published from 2021 present, pave way development innovative efficient interventions therapy.

Язык: Английский

Процитировано

1
Exploring 4-morpholinopyrrolo-[2,3-d]-pyrimidine derivatives as novel anti-cancer agents: Design, synthesis and biological studies DOI

Srinuvasu Nakka,

Swati Swati,

Kosana Sai Chaitanya

и другие.

Journal of Molecular Structure, Год журнала: 2024, Номер 1319, С. 139565 - 139565

Опубликована: Авг. 6, 2024

Язык: Английский

Процитировано

0
A review of recent developments in pharmaceutical chemistry on biological evolution of tetrazole derivatives DOI Creative Commons

Zahraa A. Ketan,

Halah A. R. Ibrahim,

Dhuha K. Slma

и другие.

Al-Salam Journal for Medical Science, Год журнала: 2024, Номер 4(1), С. 1 - 8

Опубликована: Авг. 11, 2024

This review sums up the developments in biological activity of tetrazole active derivatives recent days. Some deliberated are at present actively scientifically studied; some them have that enables to be studied further future as a drug for various activities. seeks offer comprehensive analysis efficacy and clinical advantage derivatives.

Язык: Английский

Процитировано

0