Estrogen Receptor β Alleviates Colitis by Inhibiting Ferroptosis in Intestinal Epithelial Cells DOI Creative Commons
Junrong Li, Yidong Chen, Shuang Li

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 10785 - 10805

Опубликована: Дек. 1, 2024

Ulcerative colitis (UC), a major type of inflammatory bowel disease, is characterized by chronic inflammation the colonic mucosa and submucosa. Estrogen receptor β (ERβ) predominates in colon exerts anti-inflammatory effects. Ferroptosis, recently discovered form iron-dependent programmed cell death, implicated pathogenesis several diseases, including UC. However, link between ferroptosis actions ERβ UC remains to be elucidated.

Язык: Английский

Mechanistic role of environmental toxicants in inducing cellular ferroptosis and its associated diseases DOI
Hong Chen,

Bingchun Liu,

Peixin Xu

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 298, С. 118269 - 118269

Опубликована: Май 10, 2025

Язык: Английский

Процитировано

0
Novel Tris-bipyridine Based Ru(II) Complexes as Type-I/-II Photosensitizers for Antitumor Photodynamic Therapy Through Ferroptosis and Immunogenic Cell Death DOI
Hongwei Zheng, K. Wang, Dongliang Ji

и другие.

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 279, С. 116909 - 116909

Опубликована: Сен. 24, 2024

Язык: Английский

Процитировано

2
The role of ferroptosis in reproduction. A modern view of the problem DOI
L.V. Adamyan, L.G. Pivazyan,

M.D. Yurkanova

и другие.

Russian Journal of Human Reproduction, Год журнала: 2024, Номер 30(5), С. 35 - 35

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

2
Malate dehydrogenase‐2 inhibition shields renal tubular epithelial cells from anoxia‐reoxygenation injury by reducing reactive oxygen species DOI Creative Commons
Georgios Pissas, Maria Tziastoudi,

Maria Divani

и другие.

Journal of Biochemical and Molecular Toxicology, Год журнала: 2024, Номер 38(10)

Опубликована: Сен. 17, 2024

Abstract Ischemia‐reperfusion (I‐R) injury is the most common cause of acute kidney injury. In experiments involving primary human renal proximal tubular epithelial cells (RPTECs) exposed to anoxia‐reoxygenation, we explored hypothesis that mitochondrial malate dehydrogenase‐2 (MDH‐2) inhibition redirects metabolism from mitochondria cytoplasm, towards malate‐pyruvate cycle and reversed malate‐aspartate shuttle. Colorimetry, fluorometry, western blotting showed MDH2 accelerates enhancing cytoplasmic NADPH, thereby regenerating potent antioxidant reduced glutathione. It also shuttle potentially diminished reactive oxygen species (ROS) production by transferring electrons, in form NADH, cytoplasm. The excessive ROS induced anoxia‐reoxygenation led DNA damage protein modification, triggering unfolded response, ultimately resulting apoptosis senescence. Additionally, lipid peroxidation, which may contribute process ferroptosis. Inhibiting MDH‐2 proved effective mitigating overproduction during rescuing RPTECs death or Thus, targeting holds promise as a pharmaceutical strategy against I‐R

Язык: Английский

Процитировано

1
Estrogen Receptor β Alleviates Colitis by Inhibiting Ferroptosis in Intestinal Epithelial Cells DOI Creative Commons
Junrong Li, Yidong Chen, Shuang Li

и другие.

Journal of Inflammation Research, Год журнала: 2024, Номер Volume 17, С. 10785 - 10805

Опубликована: Дек. 1, 2024

Ulcerative colitis (UC), a major type of inflammatory bowel disease, is characterized by chronic inflammation the colonic mucosa and submucosa. Estrogen receptor β (ERβ) predominates in colon exerts anti-inflammatory effects. Ferroptosis, recently discovered form iron-dependent programmed cell death, implicated pathogenesis several diseases, including UC. However, link between ferroptosis actions ERβ UC remains to be elucidated.

Язык: Английский

Процитировано

0