Disruptions in cellular communication: Molecular interplay between glutamate/NMDA signalling and MAPK pathways in neurological disorders

Neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Exploring Azithromycin’s Neuroprotective Role in Traumatic Brain Injury: Insights into Cognitive and Motor Recovery and Neuroinflammatory Modulation

Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 115 - 115

Опубликована: Янв. 16, 2025

Traumatic brain injury (TBI) is a leading cause of mortality worldwide and often results in substantial cognitive, motor, psychological impairments, triggering oxidative stress, neuroinflammation, neurodegeneration. This study examined the neuroprotective effects azithromycin (AZI) TBI. TBI was induced rats using weight-drop method. Subsequently, received daily intraperitoneal (I.P.) dose AZI (150 mg/kg) for 28 days. Behavioral tests (Morris water maze, rotarod, open field tests) were performed to assess cognitive motor functions. Neurochemical analyses included stress markers (GSH, SOD, MDA, catalase), inflammatory cytokines (TNF-α, IL-1β), apoptotic (caspase-3, Bax, Bcl-2), mitochondrial complexes (complex I, II, III, IV, V), transforming growth factor- beta (TGF-β) as neurofilament marker. Histological evaluations focused on neuronal integrity cortex, hippocampus, striatum. Treatment with significantly facilitated function recovery TBI-affected rats. At molecular level, effectively reduced markers, ameliorated neuroinflammation by decreasing TNF-α, IL-1β, apoptosis, differentially modulated complexes. assessments revealed enhanced fewer pathological changes AZI-treated compared untreated controls. shown interfere several pathways involved TBI's pathophysiology. While preclinical are promising, further studies necessary establish long-term safety efficacy clinical setting. research supports potential re-purposing novel treatment strategy related neurodegenerative disorders.

Язык: Английский

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Navigating the Complexities of Neuronal Signaling and Targets in Neurological Disorders: From Pathology to Therapeutics

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177417 - 177417

Опубликована: Фев. 1, 2025

Язык: Английский

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Therapeutic potential of Baicalin against experimental obsessive compulsive disorder: Evidence from CSF, blood plasma, and brain analysis

Journal of Neuroimmunology, Год журнала: 2025, Номер unknown, С. 578598 - 578598

Опубликована: Март 1, 2025

Язык: Английский

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Molecular Mechanisms of Neuroprotection: The Interplay of Klotho, SIRT-1, Nrf2, and HO-1 in Neurological Health

Behavioural Brain Research, Год журнала: 2025, Номер unknown, С. 115545 - 115545

Опубликована: Март 1, 2025

Язык: Английский

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Therapeutic Potential of Oleanolic acid in Modulation of PI3K/Akt/mTOR/STAT-3/GSK-3β Signaling Pathways and Neuroprotection against Methylmercury-Induced Neurodegeneration

Neurochemistry International, Год журнала: 2024, Номер 180, С. 105876 - 105876

Опубликована: Окт. 3, 2024

Язык: Английский

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Synthesis and Neurobehavioral Evaluation of a Potent Multitargeted Inhibitor for the Treatment of Alzheimer’s Disease

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Июль 15, 2024

Язык: Английский

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Therapeutic efficacy of Genistein in activation of neuronal AC/cAMP/CREB/PKA and mitochondrial ETC-Complex pathways in experimental model of autism: Evidence from CSF, blood plasma and brain analysis

Brain Research, Год журнала: 2024, Номер 1846, С. 149251 - 149251

Опубликована: Окт. 9, 2024

Язык: Английский

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Icariin is a potential neurodegenerative candidate against ammonia–glutamate excitotoxicity–oxidative stress pathway

The Journal of Basic and Applied Zoology, Год журнала: 2024, Номер 85(1)

Опубликована: Окт. 30, 2024

Язык: Английский

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