Journal of Genetic Engineering and Biotechnology,
Год журнала:
2024,
Номер
22(4), С. 100410 - 100410
Опубликована: Авг. 23, 2024
The
research
targeting
the
prevention
of
complications
through
natural
constituents,
instigated
by
cancer
has
recently
drawn
much
more
attention
over
globe.
in
this
direction
also
revealed
that
use
constituents
would
considered
a
promising
strategy
for
diminishing
aforementioned
disease
and
its
consequences.
Because
easy
availability
safe
nature,
recent
years,
resources
as
strong
anticancer
agents.
In
regard,
here
we
introduced
possibility
using
methanolic
extract
Physalis
angulata
root
candidate
implemented
applicability
LC-MS
to
unveil
presence
various
phytocompounds.
potential
exhibited
followed
ability
induce
toxicity
against
microbial
population
enhanced
interest
unveiling
phytochemical
compounds
including
Absintholide,
Curcumin
dimer
1,
Mytilin
A,
Ginsenoside
F1,
Encecalin
,
Ganoderic
acid
TQ,
Alnustone,
Rhamnetin
3-sophoroside,
Gibberellin
A14
aldehyde,
Thiolutin,
Euglobal
III
Epomusenin
B.
macro
micronutrients
suggested
is
prominent
resource
future
pharmacological
research,
especially
research.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(10), С. 5305 - 5305
Опубликована: Май 13, 2024
The
current
review
aims
to
outline
and
summarize
the
latest
research
on
aflatoxin,
with
studies
describing
natural,
herbal
chemical
compound
applications
in
animal
(pig)
models
vitro
cellular
studies.
Aflatoxin,
a
carcinogenic
toxin
metabolite,
is
produced
by
Aspergillus
flavus
humid
environments,
posing
threat
human
health
crop
production.
treatment
involves
prevention
of
exposure
aflatoxin
counteracting
its
harmful
toxic
effects,
enabling
survival
an
antidote
for
aflatoxin.
To
prospects
influence
forage
farm
production,
food
processing.
application
remedies
treat
undergoing
development
pinpoint
biochemical
pathways
responsible
effects
transmission
actions
treatment.
underline
environmental
stress
meat
dairy
products;
describe
clinical
syndromes
associated
aflatoxicosis
that
are
counteracted
proposed
preventive
interventions.
understand
how
improve
animals
feed
conditions.
PLoS ONE,
Год журнала:
2025,
Номер
20(3), С. e0319338 - e0319338
Опубликована: Март 10, 2025
Jumli
Marshi
(J.
Marshi)
,
a
native
rice
cultivar
in
Nepal,
is
gaining
popularity
owing
to
its
health
benefits
for
obesity,
hypertension,
and
diabetes.
However,
scientific
evidence
verifying
therapeutic
potential
lacking
until
November
2024.
Therefore,
we
aimed
characterize
the
phytoconstituents
evaluate
antioxidant,
antibacterial,
antidiabetic
properties
of
J.
Marshi,
along
with
ADME
toxicity
profile,
using
both
vitro
silico
approaches.
Liquid
chromatography-mass
spectrometry
analysis
70%
methanol
extract
from
identified
ten
plant-based
compounds,
including
phenolic
acids,
flavonoids,
γ-oryzanol.
The
exhibited
significant
antioxidant
properties,
neutralizing
DPPH
free
radicals
fifty-percentage
inhibitory
concentration
(IC
50
)
42.65
±
3.9
µg/mL,
compared
ascorbic
acid’s
IC
4.12
0.7
µg/mL.
It
also
showed
antibacterial
activity
against
Staphylococcus
aureus
zone
inhibition
(ZOI)
ranging
7
11
mm
minimum
(MIC)
1.56
mg/mL,
standard
antibiotics
meropenem
(ZOI:
24
1.6
mm;
MIC:
mg/mL).
enzymatic
assay
demonstrated
that
inhibits
fifty
percent
enzyme
at
(EC
>
1000
µg/mL
α
-amylase
250
2.5
-glucosidase,
contrast
acarbose,
exhibiting
an
EC
35.5
1.5
189.5
1.9
-glucosidase.
In
docking
studies
revealed
strong
interactions
target
protein
catalytic
residues,
particularly
gamma-oryzanol
(−10.0
kcal/mol)
chlorogenic
acid
-glucosidase
(−7.7
kcal/mol),
acarbose
(−6.9
−7.1
kcal/mol).
suggested
tricin
had
best
drug-likeness
safety
profiles.
To
our
knowledge,
this
first
study
reveal
presence
bioactive
acids
flavonoids.
Furthermore,
it
offers
supporting
-glucosidase-inhibitory
confirming
applications
as
functional
food
used
management
Journal of Experimental Biology and Agricultural Sciences,
Год журнала:
2025,
Номер
13(2), С. 151 - 162
Опубликована: Май 5, 2025
Cocos
nucifera
(coconut)
has
been
extensively
studied
for
its
nutraceutical
and
medicinal
properties,
but
research
on
the
haustorium
of
C.
is
limited.
This
study
aimed
to
analyze
antioxidative,
antimicrobial,
anti-inflammatory,
anticancer
properties
haustorium.
Antimicrobial
studies
were
conducted
using
a
well
diffusion
technique,
while
antioxidative
assays
included
DPPH,
ABTS,
H2O2
tests.
Anti-inflammatory
effects
assessed
egg
albumin
denaturation
HRBC
assays,
activity
was
evaluated
with
MTT
assay.
Among
tested
bacterial
strains,
maximum
inhibition
zones
13.33
±
0.58
mm
E.
coli
12.67
S.
aureus
at
100
µg/mL
concentration.
Regarding
antifungal
activity,
extract
demonstrated
minimal
effect
against
Candida
albicans.
The
notable,
DPPH
showing
74.74
1.05%,
ABTS
78.45
0.86%,
hydrogen
peroxide
71.64
0.68%,
all
concentration
50
µg/mL.
anti-inflammatory
through
assay,
which
showed
an
72.68
0.87%,
83.93
0.90%.
These
results
comparable
standard
Diclofenac
sodium,
81.33
0.95%
in
assay
88.3
0.66%
Similar
trends
observed
HepG2
cell
line.
treatment
caused
cells
shrink
fragment,
indicating
that
exhibits
significant
leading
apoptosis
human
IC50
43.91
µg/mL,
without
affecting
normal
cells.
In
conclusion,
this
highlight
nucifera,
suggesting
it
as
potential
promising
candidate
developing
novel
drugs
field
ethnopharmacology.
Plants,
Год журнала:
2024,
Номер
13(15), С. 2148 - 2148
Опубликована: Авг. 2, 2024
Few
researches
have
explored
the
production
of
pharmaceuticals
from
aquatic
plants.
Therefore,
this
study
explored,
for
first
time,
phytochemical
composition
and
bioactivities
ten
Aquatic
plant
shoots
various
Nile
River
canals
were
collected,
dried,
ground
aqueous
extract
preparation.
Phytochemical
antioxidant
capacity
assessed
using
DPPH
assays.
Extracts
tested
antiparasitic,
antibacterial,
anti-biofilm,
anticancer
activities
through
standard
in
vitro
assays,
measuring
IC50
values,
evaluating
mechanisms
action,
including
cell
viability
high-content
screening
The
results
showed
that
plants
rich
pharmaceutical
compounds.
these
extracts
exceeded
vitamin
C.
promising
antiparasitic
activity
against
pathogens
like
Opisthorchis
viverrini
Plasmodium
falciparum,
with
values
between
0.7
2.5
µg/mL.
They
also
demonstrated
low
MICs
pathogenic
bacteria,
causing
DNA
damage,
increased
plasma
membrane
permeability,
90%
biofilm
inhibition.
In
terms
activity,
effective
a
panel
cancer
lines,
Ludwigia
stolonifera
exhibiting
highest
efficacy.
Its
ranged
0.5
µg/mL
pancreatic,
esophageal,
colon
cells
to
1.5
gastric
cells.
Overall,
all
below
6
µg/mL,
showing
significant
apoptotic
nuclear
intensity,
mitochondrial
cytochrome
c
release,
outperforming
doxorubicin.
This
highlights
potential
as
sources
new,
safe,
drugs
strong
properties.
