Oxidative Stress and Neurodegeneration: Insights and Therapeutic Strategies for Parkinson’s Disease

Neurology International, Год журнала: 2024, Номер 16(3), С. 502 - 517

Опубликована: Апрель 29, 2024

Parkinson’s disease (PD) is a progressive neurodegenerative condition marked by the gradual deterioration of dopaminergic neurons in substantia nigra. Oxidative stress has been identified as key player development PD recent studies. In first part, we discuss sources oxidative PD, including mitochondrial dysfunction, dopamine metabolism, and neuroinflammation. This paper delves into possibility mitigating potential treatment approach for PD. addition, examine hurdles antioxidant therapy, challenge delivering antioxidants to brain requirement biomarkers track patients. However, even if therapy holds promise, further investigation needed determine its efficacy safety treatment.

Язык: Английский

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Ghrelin Induces Ferroptosis Resistance and M2 Polarization of Microglia to Alleviate Neuroinflammation and Cognitive Impairment in Alzheimer’s Disease

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 11, 2025

Язык: Английский

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Exploring Potential Mechanisms Accounting for Iron Accumulation in the Central Nervous System of Patients with Alzheimer’s Disease

Cells, Год журнала: 2024, Номер 13(8), С. 689 - 689

Опубликована: Апрель 16, 2024

Elevated levels of iron occur in both cortical and subcortical regions the CNS patients with Alzheimer’s disease. This accumulation is present early disease process as well more advanced stages. The factors potentially accounting for this increase are numerous, including: (1) Cells their uptake reduce export iron, becomes sequestered (trapped within lysosome, bound to amyloid β or tau, etc.); (2) metabolic disturbances, such insulin resistance mitochondrial dysfunction, disrupt cellular homeostasis; (3) inflammation, glutamate excitotoxicity, other pathological disturbances (loss neuronal interconnections, soluble β, etc.) trigger cells acquire iron; (4) following neurodegeneration, trapped microglia. Some these mechanisms also neurological disorders can begin course, indicating that a relatively common event conditions. In response pathogenic processes, directed efforts contribute buildup reflect importance correcting functional deficiency support essential biochemical processes. words, prioritize an insufficiency available while tolerating deposited iron. An analysis disease, relevant conditions, put forward.

Язык: Английский

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The role of ferroptosis in neurodegenerative diseases

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 15, 2024

Ferroptosis represents an iron − and lipid peroxidation (LPO)-mediated form of regulated cell death (RCD). Recent evidence strongly suggests the involvement ferroptosis in various neurodegenerative diseases (NDs), particularly Alzheimer’s disease (AD), Parkinson’s (PD), Huntington’s (HD), multiple sclerosis (MS), amyotrophic lateral (ALS), among others. The treatment poses both opportunities challenges context ND. This review provides a comprehensive overview characteristic features, induction inhibition ferroptosis, highlighting inhibitor underlying mechanisms responsible for its occurrence. Moreover, explores how these contribute to pathogenesis progression major disorders. Additionally, it presents novel insights into role ND summarizes recent advancements development therapeutic approaches targeting ferroptosis. These hold potential guide future strategies aimed at effectively managing debilitating medical conditions.

Язык: Английский

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Cerebral iron accumulation in multiple sclerosis: Pathophysiology and therapeutic implications

Autoimmunity Reviews, Год журнала: 2025, Номер unknown, С. 103741 - 103741

Опубликована: Янв. 1, 2025

Язык: Английский

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Unraveling the inflammation–degeneration tangle in early MS: preliminary insights from ferritin, neurogranin, TREM2, and retinal ganglion cell layer

Journal of Neurology, Год журнала: 2025, Номер 272(2)

Опубликована: Янв. 15, 2025

Multiple sclerosis (MS) involves a complex interplay between immune-mediated inflammation and neurodegeneration. Recent advances in biomarker research have provided new insights into the molecular underpinnings of MS, including ferritin, neurogranin, Triggering Receptor Expressed on Myeloid cells 2 (TREM2), neurofilaments light chain. This pilot study aims to investigate levels these biomarkers cerebrospinal fluid (CSF) MS patients explore their associations with clinical, cognitive, optical coherence tomography (OCT) parameters. cross-sectional included 26 relapsing (RMS) 13 symptomatic controls (SCs). Clinical, OCT assessments were performed, CSF samples analyzed for TREM2, neurofilaments. Neurogranin significantly higher RMS compared SCs (p = 0.04), receiver-operating characteristic (ROC) analysis indicated that neurogranin could be considered disease (AUC 0.733, p 0.01). Ferritin showed strong positive correlation (r 0.690, < 0.01), both inversely correlated retinal ganglion cell layer (GCL) thickness. TREM2 was positively associated baseline Expanded Disability Status Scale score. suggests may potential at time diagnosis, highlights relationship inflammation, oxidative stress, neuronal damage MS. The inverse association ferritin GCL thickness warrants further investigation role iron metabolism synaptic early stages disease.

Язык: Английский

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Pulmonary microbiota disruption by respiratory exposure to carbon quantum dots induces neuronal damages in mice

Journal of Hazardous Materials, Год журнала: 2025, Номер 487, С. 137255 - 137255

Опубликована: Янв. 16, 2025

Язык: Английский

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Targeting Ferroptosis in Rare Neurological Disorders Including Pediatric Conditions: Innovations and Therapeutic Challenges

Biomedicines, Год журнала: 2025, Номер 13(2), С. 265 - 265

Опубликована: Янв. 22, 2025

Ferroptosis, characterized by iron dependency and lipid peroxidation, has emerged as a key mechanism underlying neurodegeneration in rare neurological disorders. These conditions, often marked significant therapeutic gaps high unmet medical needs, present unique challenges for intervention development. This review examines the involvement of ferroptosis disease pathogenesis, focusing on its role oxidative damage neuronal dysfunction. We explore recent pharmacological advancements, including chelators, peroxidation blockers, antioxidant-based strategies, designed to target ferroptosis. While these approaches show promise, such heterogeneity, limited diagnostic tools, small patient cohorts hinder progress. Furthermore, we discuss translational regulatory barriers implementing ferroptosis-based therapies clinical practice. By addressing obstacles fostering innovative solutions, this underscores potential ferroptosis-targeting strategies revolutionize treatment paradigms

Язык: Английский

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Ferroptosis: A New Pathway in the Interaction between Gut Microbiota and Multiple Sclerosis

Frontiers in Bioscience-Landmark, Год журнала: 2025, Номер 30(1)

Опубликована: Янв. 6, 2025

Multiple sclerosis (MS) is a chronic autoimmune disorder marked by neuroinflammation, demyelination, and neuronal damage. Recent advancements highlight novel interaction between iron-dependent cell death, known as ferroptosis, gut microbiota, which may significantly influences the pathophysiology of MS. Ferroptosis, driven lipid peroxidation tightly linked to iron metabolism, pivotal contributor oxidative stress observed in Concurrently, affect systemic immunity neurological health, emerges an important regulator homeostasis inflammatory responses, thereby influencing ferroptotic pathways. This review investigates how microbiota dysbiosis ferroptosis impact MS, emphasizing their potential therapeutic targets. Through integrated examination mechanistic pathways clinical evidence, we discuss targeting these interactions could lead interventions that not only modulate disease progression but also offer personalized treatment strategies based on profiling. synthesis aims at deepening insights into microbial contributions implications setting stage for future research exploration.

Язык: Английский

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Regulation of Postoperative Cognitive Dysfunction by Glutathione Under Various Pathways: A Narrative Review

Journal of Biochemical and Molecular Toxicology, Год журнала: 2025, Номер 39(2)

Опубликована: Фев. 1, 2025

Postoperative cognitive dysfunction (POCD) is a common neurological complication after surgery and general anesthesia, the incidence increases with age. Will have negative impact on patients, family society. At present, neuroinflammation oxidative stress are main recognized mechanisms. Glutathione (GSH) powerful reducing agent may be related to POCD. Using medical search engines such as PubMed, Web of Science, we analyzed articles topics as: POCD, GSH, microglia, astrocyte, oligodendrocyte, ferroptosis, BDNF, Neuroinflammation, stress. The above searched in databases using Boolean operations. We included original articles, reviews other article types books. According reviewed literature, GSH treatment for Specific targeted therapies POCD still sparse, therefore, implementation preventive strategies appears remain optimal attitude. Further research needed better understanding

Язык: Английский

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