Edelweiss Applied Science and Technology,
Год журнала:
2024,
Номер
8(6), С. 9592 - 9604
Опубликована: Дек. 31, 2024
Knee
joint
cartilage
defects
are
a
significant
clinical
challenge
due
to
the
limited
regenerative
capacity
of
articular
cartilage,
often
leading
degeneration
and
osteoarthritis
(OA).
Conventional
treatment
methods,
such
as
surgical
repair
conservative
management,
frequently
fail
restore
function
fully.
In
recent
years,
scaffold-based
tissue
engineering
using
adipose-derived
mesenchymal
stem
cells
(ADMSCs)
has
emerged
promising
strategy
for
regeneration.
ADMSCs,
known
their
abundant
availability,
ease
isolation,
chondrogenic
potential,
provide
viable
cellular
source
repairing
damaged
cartilage.
When
combined
with
biocompatible
scaffolds,
ADMSCs
can
enhance
regeneration
by
promoting
cell
proliferation,
differentiation,
extracellular
matrix
(ECM)
formation
at
injury
site.
Various
scaffold
materials,
including
natural
synthetic
polymers,
have
been
explored
structural
support
necessary
attachment
formation.
This
literature
review
examines
current
advancements
in
application
ADMSC-loaded
scaffolds
knee
defects,
focusing
on
biological
properties,
designs,
outcomes
preclinical
studies.
The
also
addresses
challenges,
degradation,
mechanical
migration,
that
must
be
optimized
successful
translation.
Overall,
this
highlights
potential
ADMSC-based
systems
offer
solution
provides
insights
into
future
directions
improving
therapeutic
strategies
engineering.
Bioscience Reports,
Год журнала:
2024,
Номер
44(5)
Опубликована: Апрель 2, 2024
Abstract
Osteoarthritis
(OA)
is
a
long-term,
persistent
joint
disorder
characterized
by
bone
and
cartilage
degradation,
resulting
in
tightness,
pain,
restricted
movement.
Current
attempts
regeneration
are
cell-based
therapies
using
stem
cells.
Multipotent
cells,
such
as
mesenchymal
cells
(MSCs),
pluripotent
embryonic
(ESCs),
have
been
used
to
regenerate
cartilage.
However,
since
the
discovery
of
human-induced
(hiPSCs)
2007,
it
was
seen
potential
source
for
regenerative
chondrogenic
therapy
overcomes
ethical
issues
surrounding
use
ESCs
immunological
differentiation
limitations
MSCs.
This
literature
review
focuses
on
3D
bioprinting
technologies
hiPSCS,
suggesting
them
viable
successful
tissue
engineering.
Methods:
A
search
conducted
scientific
engines,
PubMed,
MEDLINE,
Google
Scholar
databases
with
terms
‘Cartilage
engineering’
‘stem
cells’
retrieve
published
engineering
MSCs,
ESCs,
hiPSCs.
Results:
hiPSCs
may
provide
an
effective
autologous
treatment
focal
chondral
lesions,
though
further
research
needed
explore
technologies.
Conclusions:
has
provided
comprehensive
overview
these
applications
medicine.
Journal of Functional Biomaterials,
Год журнала:
2024,
Номер
15(8), С. 221 - 221
Опубликована: Авг. 9, 2024
The
use
of
platelet-rich
plasma
(PRP)
in
all
medical
fields
is
currently
gaining
popularity
(1).
PRP
a
biological
product
that
can
be
defined
as
segment
the
fraction
autologous
blood
with
platelet
concentration
level
above
baseline
(2).
fact
it
has
uses
tissue
regeneration
and
wound
healing
caught
eye
orthopedic
surgeons
well,
intra-articular
treatments
have
continued
to
evolve.
Its
benefits
treatment
different
osteoarticular
pathologies
are
great
interest
evolving
community,
targeting
mostly
knee
osteoarthritis,
meniscus
ligament
injuries
(3).
purpose
this
review
update
reader
on
current
osteoarthritis
pathology
provide
clinical
feedback
its
sports
medicine
practice
(4).
We
proceeded
studying
180
titles
abstracts
eligible
for
inclusion.
Compared
alternative
treatments,
injections
greatly
improve
function
joint.
Tissue Engineering Part A,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Cartilage
injuries
are
extremely
common
in
the
general
population,
and
conventional
interventions
have
failed
to
produce
optimal
results.
Tissue
engineering
(TE)
technology
has
been
developed
neocartilage
for
use
a
variety
of
cartilage-related
conditions.
However,
progress
field
cartilage
TE
historically
difficult
due
high
functional
demand
avascular
nature
tissue.
Recent
advancements
cell
sourcing,
biostimulation,
scaffold
revolutionized
made
clinical
application
this
reality.
will
continue
expand
its
horizons
fully
integrate
three-dimensional
printing,
gene
editing,
sourcing
future.
This
review
focuses
on
recent
landscape
treatments
conditions.AbstractImpact
StatementCartilage
tissue
potential
transform
practice
through
swift
generation
integrative
neotissues.
There
is
an
increasing
effective
therapies
conditions
such
as
osteoarthritis
focal
lesions,
scientific
breakthroughs
brought
closer
widespread
use.
with
emphasis
applications
that
can
further
enhance
contribute
improved
care
patients.
Tissue Engineering Part B Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Cartilage
tissue
engineering
(CTE)
has
revolutionized
the
field
of
regenerative
medicine,
offering
significant
advancements
in
surgeries
such
as
autologous
chondrocyte
transplantation.
However,
despite
these
advancements,
infections
associated
with
cartilage
implants
remain
a
persistent
challenge,
compromising
success
and
patient
recovery.
To
address
challenges,
this
review
provides
comprehensive
foundation
for
researchers
interested
addressing
CTE.
It
begins
by
briefly
outlining
major
scaffolds
currently
used
CTE
distinguishing
those
antimicrobial
properties.
Among
identified,
chitosan
chondroitin
sulfate
stand
out
their
promising
compatibility
antibacterial
The
then
explores
additives
that
meet
three
essential
criteria:
chondrocytes,
suitability
use
scaffolds,
efficacy.
Chitosan,
zinc
oxide,
silver,
copper
emerge
leading
candidates
due
to
chondrocytes
proven
capabilities.
Importantly,
criteria
were
chosen
provide
practical
reliable
starting
point
immediate
application.
it
is
acknowledged
other
modifications
fabrication
processes
bioactive
glass
graphene
which
may
not
fit
criteria,
also
hold
potential
future
research
innovation.
This
underscores
need
further
development
enhance
infection
control
measures
improve
outcomes.
Macromolecular Materials and Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Abstract
Cartilage
defects
are
common
joint
disorders
that,
if
left
untreated,
may
progress
to
severe
degenerative
conditions.
Inflammatory
response
plays
a
critical
role
in
the
pathogenesis
of
cartilage
damage.
Hydrogels
incorporating
diacerein,
an
anti‐inflammatory
drug
used
clinical
settings,
can
mitigate
inflammation
that
impairs
repair.
It
is
hypothesized
direct
injection
hydrogel
scaffold
combining
diacerein
and
polydopamine
into
defect
sites
enhance
localized
treatment,
reduce
surgical
risks,
expedite
recovery.
Therefore,
this
study,
infused
with
developed
investigate
its
efficacy
for
restoration.
By
crosslinking
poly(ethylene
glycol)
diacrylate,
four‐arm
polyethylene
glycol‐functionalized
hyaluronic
acid,
polydopamine,
injectable
superior
properties
achieved.
In
vitro
evaluations
confirm
mechanical
strength
biocompatibility
hydrogel,
vivo
studies
demonstrate
effectiveness
repair
activity
rat
model.
These
findings
indicate
hydrogels
promising
materials
addressing
advancing
tissue
engineering
biological
implantation
strategies.
Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 570 - 570
Опубликована: Фев. 24, 2025
This
narrative
review
provides
an
overview
of
the
various
diagnostic
tools
used
to
assess
cartilage
health,
with
a
focus
on
early
detection,
nutrition
intervention,
and
management
osteoarthritis.
Early
detection
damage
is
crucial
for
effective
patient
management.
Traditional
like
radiography
conventional
magnetic
resonance
imaging
(MRI)
sequences
are
more
suited
detecting
late-stage
structural
changes.
paper
highlights
advanced
techniques,
including
sodium
MRI,
T2
mapping,
T1ρ
imaging,
delayed
gadolinium-enhanced
MRI
cartilage,
which
provide
valuable
biochemical
information
about
composition,
particularly
glycosaminoglycan
content
its
potential
links
nutrition-related
factors
influencing
health.
Cartilage
degradation
often
linked
inflammation
measurable
via
markers
CRP
IL-6
which,
although
not
specific
breakdown,
offer
insights
into
affecting
cartilage.
In
addition
markers,
such
as
collagen
breakdown
products
aggrecan
fragments,
reflect
metabolic
changes
in
discussed.
Emerging
optical
coherence
tomography
hybrid
positron
emission
tomography–magnetic
(PET-MRI)
also
explored,
offering
high-resolution
combined
insights,
respectively.
Finally,
wearable
technology
biosensors
real-time
monitoring
osteoarthritis
progression,
well
role
artificial
intelligence
enhancing
accuracy
through
pattern
recognition
data
addressed.
While
these
hold
great
osteoarthritis,
challenges
remain
clinical
translation,
validation
larger
populations
integration
existing
workflows
personalized
treatment
strategies
cartilage-related
diseases.
