Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(12), С. 13746 - 13766
Опубликована: Дек. 4, 2024
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
chronic,
deathly
disease
with
no
recognized
effective
cure
as
yet.
Furthermore,
its
diagnosis
and
differentiation
from
other
diffuse
interstitial
diseases
remain
challenge.
Circulating
miRNAs
have
been
measured
in
IPF
proven
to
be
an
adequate
option
biomarkers
for
this
disease.
These
miRNAs,
released
into
the
circulation
outside
cell
through
exosomes
proteins,
play
crucial
role
pathogenic
pathways
mechanisms
involved
development.
This
review
focuses
on
serum/plasma
reported
that
validated
by
real-time
PCR
published
evidence
regarding
fibrotic
process.
First,
we
describe
which
travel
(contained
bound
proteins),
well
mechanism
perform
their
function
within
cell.
Subsequently,
summarize
concerning
serum/plasma,
where
find
contradictory
functions
some
(dual
IPF)
when
comparing
findings
vitro
vs.
vivo.
The
most
relevant
finding,
instance,
levels
of
let-7d
miR-21
IPF,
correspond
those
found
studies
lung
fibroblasts
murine
bleomycin
model,
reinforcing
usefulness
these
future
IPF.
Biology,
Год журнала:
2024,
Номер
13(10), С. 774 - 774
Опубликована: Сен. 27, 2024
Our
study
aimed
to
elucidate
the
mechanisms
behind
interaction
between
calcium
oxalate
(CaOx)
crystals
and
renal
tubular
epithelial
cells
through
transcriptome
sequencing
analysis.
HK-2
were
stimulated
with
or
without
CaOx
monohydrate
subjected
RNA-seq
assess
effects
of
on
gene
expression
changes,
key
pathways,
molecular
players
during
this
interaction.
A
total
629
differentially
expressed
genes
(DEGs)
identified
control
group
experimental
group,
491
up-regulated
138
down-regulated.
Functional
enrichment
analysis
indicated
that
DEGs
significantly
associated
endoplasmic
reticulum
stress
(ERS)
unfolded
protein
response.
To
validate
our
findings,
we
compared
results
public
dataset
GSE73680
confirmed
increased
two
ERS-related
DEGs,
CHAC1
FGF21,
in
papillary
tissues
from
patients
stones.
Collectively,
these
findings
suggest
ERS
plays
a
crucial
role
crystal-cell
highlight
potential
for
developing
therapeutic
strategies
at
reducing
stone
formation
by
targeting
molecules
pathways.
Cell Stress and Chaperones,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Endothelial
injury
can
be
the
cause
and
consequence
of
severe
inflammation
injury.
Synthetic
somatostatin
analogs
-
which
suppress
Growth
Hormone
are
FDA-approved
drugs
associated
with
anti-inflammatory
activities.
In
present
study
we
suggest
that
protective
activities
Octreotide
in
human
bovine
endothelial
cells
mitigated
by
Ceapin-A7,
is
an
activating
transcription
factor
6
suppressor.
To
function,
assessed
protein
expression
levels
key
cytoskeletal
proteins,
as
well
paracellular
permeability.
evaluate
inflammation,
measured
factors
promote
vascular
leak,
reactive
oxygen
species
generation.
Collectively,
our
supports
involvement
effects
barrier
function.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(12), С. 13746 - 13766
Опубликована: Дек. 4, 2024
Idiopathic
pulmonary
fibrosis
(IPF)
is
a
chronic,
deathly
disease
with
no
recognized
effective
cure
as
yet.
Furthermore,
its
diagnosis
and
differentiation
from
other
diffuse
interstitial
diseases
remain
challenge.
Circulating
miRNAs
have
been
measured
in
IPF
proven
to
be
an
adequate
option
biomarkers
for
this
disease.
These
miRNAs,
released
into
the
circulation
outside
cell
through
exosomes
proteins,
play
crucial
role
pathogenic
pathways
mechanisms
involved
development.
This
review
focuses
on
serum/plasma
reported
that
validated
by
real-time
PCR
published
evidence
regarding
fibrotic
process.
First,
we
describe
which
travel
(contained
bound
proteins),
well
mechanism
perform
their
function
within
cell.
Subsequently,
summarize
concerning
serum/plasma,
where
find
contradictory
functions
some
(dual
IPF)
when
comparing
findings
vitro
vs.
vivo.
The
most
relevant
finding,
instance,
levels
of
let-7d
miR-21
IPF,
correspond
those
found
studies
lung
fibroblasts
murine
bleomycin
model,
reinforcing
usefulness
these
future
IPF.
