Seminars in Ophthalmology, Год журнала: 2024, Номер unknown, С. 1 - 13
Опубликована: Окт. 26, 2024
The burst of modern information has significantly promoted the development global medicine into a new era big data healthcare. Ophthalmology is one most prominent medical specialties driven by analytics. This study aimed to describe status and research hotspots in ophthalmology.
Язык: Английский
Pharmaceutics, Год журнала: 2025, Номер 17(3), С. 302 - 302
Опубликована: Фев. 25, 2025
Background Despite many studies on polymer-incorporated nanocarriers for ophthalmic drug delivery, few have thoroughly explored the relationship between coating composition and performance. This study aimed to evaluate effects of three commonly used cationic polymers—distearoyl phosphatidylethanolamine-polyethylene glycol 1000-poly(amidoamine) (DSPE-PEG1000-PAMAM), trimethyl chitosan (TMC), (2,3-dioleoyloxypropyl) trimethylammonium chloride (DOTAP)—on corneal behaviors anti-cataract efficacy diosmetin (DIO)-loaded micelles (D-M-P, D-M-T, D-M-D, respectively). Methods The DIO-loaded were prepared using thin-film dispersion method incorporated with polymers through hydrophobic interactions electrostatic adsorption. Structural characterization was demonstrated by TEM imaging particle size analyzer. In vitro release behavior detected dialysis method. Cell viability D-M-P, D-M-D L929 cells CCK-8 assays, cellular uptake performed coumarin 6 as fluorescence indicator. Precorneal retention these vesicles observed Vivo Imaging System. Transcorneal permeability determined modified Franz diffusion permeation routes are investigated. Selenite-induced cataract model established. different evaluated observation lens opacity antioxidant enzyme activities. Eye Irritation DIO in preparations estimated Draize test, along H&E staining corneas. Results revealed that spherical, a uniform distribution around 28 nm, similar surface potential approximately 6.0 mV, high entrapment efficiency about 95%. Compared suspension, all formulations exhibited significant sustained-release effect. They showed no signs irritation increased IC50 values cells, indicating improved biocompatibility. Cellular human epithelial (HLECs) assessed confocal laser scanning microscopy. C-M-T displayed highest signals, internalization 3.2 times greater than solution group. Both C-M-P enhanced vesicle at least 47.8% compared Cou-6 solution. Furthermore, TMC facilitated paracellular transport into deepest layers cornea delivered across cornea, Papp value 3.11 1.49 those respectively. terms therapeutic efficacy, D-M-T most attenuation opacity, activities inhibition lipid peroxidation. Conclusion modification micelle significantly influences their performance ocular delivery. Among tested formulations, stands out due its multiple advantages, including transcorneal DIO, safety, making it promising candidate applications.
Язык: Английский
Процитировано
0
Regenerative medicine and dentistry., Год журнала: 2025, Номер unknown, С. 4 - 4
Опубликована: Март 17, 2025
Review Global Research Trends and Hotspots in Meibomian Gland Dysfunction (2014–2023): A Comprehensive Bibliometric Visualization Analysis Qian Liu 1, Fangkun Zhao 2, Jun Minmei Guo Chengyu Jiang Tao Yu Ting Wang Tzu-Cheng Sung Kong 2 Akon Higuchi 1,3,* 1 State Key Laboratory of Ophthalmology, Optometry Visual Science, Eye Hospital, Wenzhou Medical University, 325027, China Department the Fourth Affiliated Hospital Shenyang 110005, 3 Chemical Materials Engineering, National Central Taoyuan 32001, Taiwan * Correspondence: [email protected] or [email protected]; Tel.: +86-577-88068822; Fax: +86-086-577-88832083 Received: 21 January 2025; Revised: 11 March Accepted: 12 Published: 17 2025 Abstract: This study aimed to explore global research landscape, emerging hotspots, advancements (MGD) over last decade through a bibliometric visualization analysis for regenerative medicine strategy treat MGD patients. Data were collected from Web Science Core Collection, covering period 2014 2023. VOSviewer CiteSpace used analyze visualize publication trends, contributions by countries institutions, co-authorship analysis, journal impact, keyword co-occurrence. Emerging topics identified using citation burst analysis. total 1271 publications included. Four major hotspots identified: (1) etiology pathogenesis, (2) diagnostic technologies, (3) therapeutic innovations, (4) epidemiological trends. The United States Yonsei University leading contributors terms counts. Ocular Surface, Cornea, Investigative Ophthalmology & top journals productivity impact. revealed significant progress highlighted key areas requiring further investigation, including establishment standards targeted therapies medicine. These findings provide roadmap future collaborative efforts strategic directions field.
Язык: Английский
Процитировано
0
International Ophthalmology, Год журнала: 2025, Номер 45(1)
Опубликована: Апрель 10, 2025
Язык: Английский
Процитировано
0
Expert Opinion on Pharmacotherapy, Год журнала: 2024, Номер 25(16), С. 2107 - 2113
Опубликована: Окт. 23, 2024
Keywords: cataract surgeryocular painpost-operative pain, inflammationpharmacotherapyneuropathic painneuromodulatory therapies
Язык: Английский
Процитировано
0
Seminars in Ophthalmology, Год журнала: 2024, Номер unknown, С. 1 - 13
Опубликована: Окт. 26, 2024
The burst of modern information has significantly promoted the development global medicine into a new era big data healthcare. Ophthalmology is one most prominent medical specialties driven by analytics. This study aimed to describe status and research hotspots in ophthalmology.
Язык: Английский
Процитировано
0