Single‐Atom Catalysts with Isolated Cu1‐N4 Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling DOI
Le Kuai,

Fang Huang,

Lijie Mao

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Abstract Atopic dermatitis (AD) is one of the most common allergic skin disorders affecting over 230 million people worldwide, while safe and efficient therapeutic options for AD are currently rarely available. Reactive oxygen species (ROS) accumulation plays a key role in AD's disease progression. Therefore, novel single‐atom catalyst designed with isolated Cu 1 ‐N 4 sites anchored on carbon support (Cu ISAC), featuring triple antioxidant enzyme‐mimicking activities, cascade catalytic therapy (CCT). The excellent superoxide dismutase (SOD)‐, glutathione peroxidase (GPx)‐, ascorbate (APx)‐like activities ISACs enable sequential conversion O 2 • − to H then harmless O, thereby protecting keratinocytes from oxidative stress damage. Notably, two experimental methods developed directly prove SOD‐GPx SOD‐APx first time. In vivo experiments show that more potent than recommended typical medicine (halcinonide solution). Additionally, RNA sequencing bioinformatic analysis reveal reduce inflammation inhibit ROS production by activating PPAR signaling, which aberrantly reduced AD. synthesized offers an alternative alleviate has potential serve as agonists treating similar diseases.

Язык: Английский

Altered cognitive function in obese patients: relationship to gut flora DOI Creative Commons

Mengyuan Deng,

Fushan Tang, Zhaoqiong Zhu

и другие.

Molecular and Cellular Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Язык: Английский

Процитировано

2
Chinese Herbal Medicine and Their Active Ingredients Involved in the Treatment of Atopic Dermatitis Related Signaling Pathways DOI Open Access

W. Nie,

Hao Fu, Yan Zhang

и другие.

Phytotherapy Research, Год журнала: 2025, Номер 39(2), С. 1190 - 1237

Опубликована: Янв. 7, 2025

Atopic dermatitis (AD) is a common inflammatory of the skin and poses therapeutic challenges due to adverse reactions high costs associated with available treatments. In Eastern Asian countries, plethora herbal remedies extensively employed for alleviation AD. Many these botanicals are renowned their formidable anti-inflammatory properties, contributing AD management. Chinese medicine (CHM) its active ingredients exhibit both prophylactic promise against by modulating response, orchestrating immune system functions, enhancing antioxidant activities. A comprehensive exploration underlying mechanisms involved in CHM treatment can enhance comprehension pathogenesis facilitate development innovative drugs This study aims elucidate signaling pathways potential targets implicated CHM-based AD, providing systematic theoretical framework application therapy while serving as valuable reference developing more effective safer agents.

Язык: Английский

Процитировано

0
Single‐Atom Catalysts with Isolated Cu1‐N4 Sites for Atopic Dermatitis Cascade Catalytic Therapy via Activating PPAR Signaling DOI
Le Kuai,

Fang Huang,

Lijie Mao

и другие.

Small, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Abstract Atopic dermatitis (AD) is one of the most common allergic skin disorders affecting over 230 million people worldwide, while safe and efficient therapeutic options for AD are currently rarely available. Reactive oxygen species (ROS) accumulation plays a key role in AD's disease progression. Therefore, novel single‐atom catalyst designed with isolated Cu 1 ‐N 4 sites anchored on carbon support (Cu ISAC), featuring triple antioxidant enzyme‐mimicking activities, cascade catalytic therapy (CCT). The excellent superoxide dismutase (SOD)‐, glutathione peroxidase (GPx)‐, ascorbate (APx)‐like activities ISACs enable sequential conversion O 2 • − to H then harmless O, thereby protecting keratinocytes from oxidative stress damage. Notably, two experimental methods developed directly prove SOD‐GPx SOD‐APx first time. In vivo experiments show that more potent than recommended typical medicine (halcinonide solution). Additionally, RNA sequencing bioinformatic analysis reveal reduce inflammation inhibit ROS production by activating PPAR signaling, which aberrantly reduced AD. synthesized offers an alternative alleviate has potential serve as agonists treating similar diseases.

Язык: Английский

Процитировано

2